Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Shimadzu HPLCs Used for Finding Cancer Treatment

Published: Thursday, November 09, 2006
Last Updated: Thursday, November 09, 2006
Bookmark and Share
Researchers are using LC10 Vp series and Prominence high performance liquid chromatography systems.

Researchers at the University of Manchester, Wolfson Molecular Imaging Centre, UK, have announced that they are using Shimadzu instruments to obtain proof of concept measurements for the mode of action and efficacy of new drugs to treat cancer and brain disorders.

They are using four LC10 Vp series and four Prominence high performance liquid chromatography (HPLC) systems, complementing positron emission tomography (PET) technology in their work on drug metabolite analysis.

"We are labelling novel drug candidate molecules with positron-emitting radioisotopes to inject into human volunteers and track using PET scanners," explained Dr Adam McMahon, Team Leader in Radio Analytical and Synthetic Radiochemistry.

"Before injection of the drug we use an LC10 Vp series to perform rapid and reliable checks for both chemical and radiant purity of the labelled molecules and, following injection, the patient's blood samples are analysed by the other HPLC systems to study metabolites carrying the radiotracer."

"Two of the Prominence systems are reserved for method development and for LC/MS studies."

"Using these instruments, we can see if a molecule might be a potentially successful drug at these early stages of drug development, before committing to further investment in major clinical trials."

Dr McMahon concluded, "The Shimadzu HPLC systems have great robustness and reliability, which is important because it is critical to have reproducible results."


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More Than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Shimadzu Wins R&D 100 Award for Nexera Unified Chromatography System
The Nexera UC system is the world’s first ever unified and fully automated system that combines supercritical fluidic extraction (SFE) with supercritical fluid chromatography (SFC).
Tuesday, November 24, 2015
Agilent, Shimadzu Release GC Instrument Control for CDS
The instrument control provides customers more freedom of choice when selecting a chromatography data system.
Wednesday, August 27, 2014
Shimadzu, Indigo BioSystems Announce Partnership
The companies will leverage the power of ASCENT™ clinical solutions on ultra-fast mass spectrometry platforms.
Monday, June 16, 2014
Shimadzu Corporation, MacCoss Lab of Biological Mass Spectrometry, UW Collaborate
The companies will leverage the power of ASCENT™ clinical solutions on ultra-fast mass spectrometry platforms.
Monday, June 16, 2014
Shimadzu Registers HPLC and LCMS Instruments as Class I Medical Devices with FDA
Products are the first Shimadzu analytical instruments registered with the FDA as medical devices.
Tuesday, April 01, 2014
Shimadzu Establishes Latin American Subsidiary
Uruguayan subsidiary will strengthen company's sales and distribution whilst providing better support for customers and distributors in Central and South America.
Tuesday, November 12, 2013
Shimadzu Achieves ISO 13485 Certification for US LC-MS Facility
ISO 13485 is the globally recognized international quality management standard for medical equipment.
Wednesday, September 25, 2013
Shimadzu UK Grows Sales Orders by 30%!
Company has achieved sales order growth across many products in the Shimadzu range.
Tuesday, May 07, 2013
Shimadzu UK Appoints Product Specialist for AA
Company strengthens focus on molecular and atomic spectroscopy with new specialist recruit.
Thursday, July 19, 2012
Shimadzu and The University of Texas Form Shimadzu Center for Advanced Analytical Chemistry
Located in the university’s Chemistry & Physics Building, the center contains $6 million of chromatography, mass spectrometry and spectroscopy equipment, which is the largest installation of Shimadzu analytical instrumentation in the Western Hemisphere.
Tuesday, April 10, 2012
Shimadzu Corporation Names New Director and President of Shimadzu Scientific Instruments
Shuzo Maruyama has been named president of Shimadzu Scientific Instruments (SSI)
Monday, March 12, 2012
Spectroscopy Veteran Joins Shimadzu UK to Drive UK Sales Forward
Dr Robert Keighley has appointed as new spectroscopy and TOC business manager.
Friday, September 16, 2011
Shimadzu UK Opens Evaluation Laboratory Centre to Promote Excellence in Analytical Instrumentation
New 1500m² world-class product evaluation laboratory facility at UK headquarters in Buckinghamshire.
Wednesday, July 13, 2011
Multivariate Data Analysis Solutions for FTIR Spectrophotometry
Shimadzu Scientific Instruments and CAMO Software have announced a partnership that will enable Shimadzu to expand its capabilities for FTIR spectrophotometry. Shimadzu will now provide CAMO Software’s multivariate data analysis (MVDA) software, The Unscrambler® to FTIR customers requiring chemometric analysis.
Friday, November 05, 2010
Shimadzu, Ceres Nanosciences and Nonlinear Dynamics Introduce Nanotrap™ Biomarker Discovery Platform
Shimadzu Scientific Instruments has partnered with Ceres Nanosciences and Nonlinear Dynamics to bring the future of biomarker discovery to laboratory researchers.
Tuesday, March 16, 2010
Scientific News
Ketamine Metabolism Lifts Depression
NIH-funded team finds rapid-acting, non-addicting agent in mouse study.
Faster, Cheaper Way to Produce New Antibiotics
A novel way of synthesising a promising new antibiotic has been identified by scientists at the University of Bristol.
Process Contaminants in Vegetable Oils and Foods
Glycerol-based process contaminants found in palm oil, but also in other vegetable oils, margarines and some processed foods, raise potential health concerns for average consumers of these foods in all young age groups, and for high consumers in all age groups.
Improving Natural Killer Cancer Therapy
Vanderbilt University researchers discover transcription factor critical for NK cell expansion. Findings could lead to increased therapeutic efficacy.
Molecular Mechanism For Generating Specific Antibody Responses Discovered
Study could spur more ways to treat autoimmune disease, develop accurate vaccines.
Monovar Drills Down Into Cancer Genome
Rice, MD Anderson develop program to ID mutations in single cancer cells.
It’s Now Easier To Go With The Flow
Rice University tool simplifies comparison of flow cytometry data for laboratories.
Autism, Cancer Share a Remarkable Number of Risk Genes
Researchers with the UC Davis Comprehensive Cancer Center, MIND Institute identify more than 40 common genes.
Number Of Known Genetic Risk Factors For Endometrial Cancer Doubled
An international collaboration of researchers has identified five new gene regions that increase a woman’s risk of developing endometrial cancer, one of the most common cancers to affect women, taking the number of known gene regions associated with the disease to nine.
Genetic Variant May Help Explain Why Labradors Are Prone To Obesity
A genetic variation associated with obesity and appetite in Labrador retrievers – the UK and US’s favourite dog breed – has been identified by scientists at the University of Cambridge. The finding may explain why Labrador retrievers are more likely to become obese than dogs of other breeds.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!