Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Gene Discovered by Researchers Tied to Pancreatic Cancer

Published: Monday, December 18, 2006
Last Updated: Wednesday, December 20, 2006
Bookmark and Share
The gene, palladin, is involved is involved in the formation of scar tissue on nerve cells in the brain or spinal cord.

A gene discovered by researchers at the University of North Carolina at Chapel Hill School of Medicine has been associated with two forms of pancreatic cancer, according to a study by an international group of researchers.

The gene, called palladin, was discovered six years ago by Dr. Carol Otey and her former student, Dr. Mana Parast, now a pathology fellow with Brigham and Women’s Hospital in Boston.

Otey has shown that palladin is involved in the formation of scar tissue on nerve cells in the brain or spinal cord, and it’s found in cells that are moving, including embryonic cells and cells at the edge of wounds.

“Now we find it implicated in pancreatic cancer,” said Otey, an associate professor of cell and molecular physiology at UNC and a member of the UNC Neuroscience Center.

A study reported in the Dec. 12 issue of PLOS-Medicine, led by scientists at the University of Washington and the University of Pittsburgh, found pallidan overexpressed in people with sporadic, or non-familial, pancreatic cancer.

A mutation of the gene was overexpressed in cells of people with familial pancreatic cancer, which makes up at least 10 percent of all pancreatic cancer cases. Otey is a co-author on the paper. This discovery could lead to earlier diagnosis and more targeted treatments.

In the United States, pancreatic cancer is the fourth leading cause of cancer death and the third leading cause of cancer death among people 40 to 59 years. Most people with the disease die within a year of diagnosis; about 95 percent of patients die within five years.

Palladin, which Otey named for 16th century architect Andrea Palladio, “is very involved in the architecture of cells, specifically via the actin cytoskeleton, a polymer protein complex that provides much of the basis for cell shape,” Otey said.

In 1996 Dr. Teresa A. Brentnall, an associate professor of medicine at the University of Washington, became aware of a family in which 18 members, over four generations, died of pancreatic cancer.

Subsequent DNA samples from this family, including from those with the initial stages of pancreatic cancer and those without the disease, led to the isolation of palladin on a particular region of chromosome 4.

Dr. Kay L. Pogue-Geile, assistant director of microarray at the National Surgical Adjuvant Breast and Bowel Project Laboratory in Pittsburgh, developed a customized DNA microarray to assess genes in that region of the chromosome and looked for gene overexpression or overactivity. Pogue-Geile and Brentnall share first authorship on the PLOS paper.

The analysis found a mutated palladin gene in all family members affected with early stage disease but not in those unaffected. The mutation was associated with gene overexpression 21 times greater than other genes in that region.

Moreover, in pancreas cells of people with sporadic pancreatic cancer, the research team found palladin also overexpressed, and increasingly so, as the disease progressed.

The study team said these findings could account for changes in the cytoskeletal architecture of pancreatic cancer cells, and those alterations “may be responsible for the tumor’s invasive and migratory abilities.”

“We don’t know how the palladin mutation found in this study contributes to the movement or invasiveness of cancer cells. That’s the part of the story we still have to figure out,” Otey said.

Research support for Otey in this study came from the National Institute of Neurological Disorders and Stroke, a component of the National Institutes of Health.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More Than 4,400+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Scientists Create Painless Patch of Insulin-Producing Beta Cells to Control Diabetes
Researchers at UNC and NC State have developed the new “smart cell patch” to treat millions of people with type-1 and advanced type-2 diabetes.
Saturday, March 19, 2016
Device Hits Pancreatic Tumors Hard With Toxic Four-Drug Cocktail, Sparing The Body
Researchers at UNC have revealed that an implantable device can deliver a particularly toxic cocktail of drugs directly to pancreatic tumors to stunt their growth and shrink them.
Saturday, February 27, 2016
Stem Cells Turned into Cancer Killers
Skin cells turned cancer-killing stem cells hunt down and destroy the deadly remnants inevitably left behind when a brain tumor is surgically removed.
Friday, February 26, 2016
Stem Cells Turned into Cancer Killers
Skin cells turned cancer-killing stem cells hunt down and destroy the deadly remnants inevitably left behind when a brain tumor is surgically removed.
Friday, February 26, 2016
Potential Brain Cancer Drug Target
UNC Lineberger researchers have reporedt that when they removed Dicer from preclinical models of medulloblastoma, a common type of brain cancer in children, they found high levels of DNA damage in the cancer cells, leading to the cells’ death.
Friday, January 08, 2016
New Path for ALS Drug Discovery
For the first time, scientists pin down the structure of toxic clumps of a protein associated with a large number of ALS cases, opening new avenues in the pursuit of drugs to stem the disease.
Thursday, January 07, 2016
New Way to Force Stem Cells to Become Bone Cells
Potential therapies based on this discovery could help people heal bone injuries or set hardware, such as replacement knees and hips.
Monday, November 16, 2015
Autism Mutation Isolated – Could Be Treated with Specific Enzyme
The research shows the precise cellular mechanisms that could increase risk for the disorder and how an existing drug might help thousands of people with autism.
Monday, August 10, 2015
Researchers Find Two Biomarkers Linked to Severe Heart Disease
Study suggests that elevated oxidized LDL cholesterol and fructosamine – a measure of glycated proteins in blood sugar – are signposts for the development of severe coronary disease, especially in females.
Thursday, July 09, 2015
A Single-Cell Breakthrough
UNC School of Medicine scientist Scott Magness and collaborators use their newly developed technology to dissect properties of single stem cells. The advancement will allow researchers to study gastrointestinal disorders and cancers like never before.
Thursday, March 19, 2015
New Gene Therapy For Hemophilia Shows Potential As Safe Treatment
Research showed that bleeding events were drastically decreased in animals with hemophilia B. Using a viral vector to swap out faulty genes proved safe and could be used for the more common hemophilia A.
Tuesday, March 17, 2015
Genetically Speaking, Mammals Are More Like Their Fathers
A first of its kind study shows that who we inherit genetic variants from – our mother or father – is crucial for the development of diseases and for research studies aimed at finding causes and potential treatments.
Wednesday, March 04, 2015
Key Protein That Allows Plavix To Conquer Platelets Found
The findings could lead to more personalized approaches to controlling platelet activity during heart attacks and other vascular emergencies and diseases.
Wednesday, February 25, 2015
Researchers Silence Leading Cancer-Causing Gene
A novel siRNA-based molecule successfully targets KRAS, a well-studied but hard to halt protein important for cancer development and metastasis.
Monday, November 17, 2014
Blood Test May Help Determine Psychosis Risk
A study led by University of North Carolina at Chapel Hill researchers represents an important step forward in the accurate diagnosis of people who are experiencing the earliest stages of psychosis.
Tuesday, September 23, 2014
Scientific News
Releasing Cancer Cells for Better Analysis
A new device developed at the University of Michigan could provide a non-invasive way to monitor the progress of an advanced cancer treatment.
Releasing Cancer Cells for Better Analysis
A new device developed at the University of Michigan could provide a non-invasive way to monitor the progress of an advanced cancer treatment.
Apricot Kernels Pose Risk of Cyanide Poisoning
Eating more than three small raw apricot kernels, or less than half of one large kernel, in a serving can exceed safe levels. Toddlers consuming even one small apricot kernel risk being over the safe level.
Cell Transplant Treats Parkinson’s in Mice
A University of Wisconsin—Madison neuroscientist has inserted a genetic switch into nerve cells so a patient can alter their activity by taking designer drugs that would not affect any other cell.
Understanding Female HIV Transmission
Glowing virus maps points of entry through entire female reproductive tract for first time.
Genetic Markers Influence Addiction
Differences in vulnerability to cocaine addiction and relapse linked to both inherited traits and epigenetics, U-M researchers find.
Lab-on-a-Chip for Detecting Glucose
By integrating microfluidic chips with fiber optic biosensors, researchers in China are creating ultrasensitive lab-on-a-chip devices to detect glucose levels.
A lncRNA Regulates Repair of DNA Breaks in Breast Cancer Cells
Findings give "new insight" into biology of tough-to-treat breast cancer.
COPD Linked to Increased Bacterial Invasion
Persistent inflammation in COPD may result from a defect in the immune system that allows airway bacteria to invade deeper into the lung.
Detection of HPV in First-Void Urine
Similar sensitivity of HPV test on first void urine sample compared to cervical smear.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,400+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!