Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Scientists Found a Way to Enhance Development of Human Embryonic Stem Cells Therapies

Published: Tuesday, January 23, 2007
Last Updated: Tuesday, January 23, 2007
Bookmark and Share
Scientists at the Genome Institute of Singapore and the National University of Singapore have found a way of manipulating ESCs that allows stem cells to be produced for use in clinical treatments.

Scientists at the Genome Institute of Singapore (GIS) and the National University of Singapore (NUS) have found a way of manipulating embryonic stem cells (ESCs) that could allow stem cells to be produced in a safe and manner for use in clinical treatments.

According to the Scientists, as ESCs have the potential to develop into any cell type within the body, the risk of using ESCs in clinical treatments is that the ESCs may develop into an inappropriate cell type for the tissue or organ that is being treated.

To reduce the risk of such tumour formation and increase the efficiency of generating clinically important cells, the scientists at GIS and NUS used mouse embryonic stem cells (mESCs) to first generate less potent daughter stem cell lines. These daughter stem cells are able to form some but not all cell types.

As such, they cannot form teratomas and they are also efficient in forming specific cell types such as blood vessel cells. At the same time, these daughter stem cells retain the ability of their parental ESCs to grow and multiply on culture dishes and to differentiate to become part of an existing tissue structure.

The results of this research were published in PLoS ONE (December 2006 issue).

This research can help to address two of the most important challenges to the development of therapeutic applications of ESC: namely, (a) how to derive clinically important cell types from ESC in sufficiently large and highly purified amounts for therapy, and (b) how to minimise the risk of tumour formation.

The eventual objective is to transfer this technology for deriving daughter stem cell lines from mice to human ESCs for developing clinical treatments using stem cells.

Dr Lim Sai Kiang of GIS said, "This study using mouse ESCs provides in-principle proof that generating daughter stem cell lines is a viable alternative strategy to circumvent the current challenges in using ESCs for therapy, i.e., efficient production of therapeutic cell types and minimization of the risk of tumour formation. This research will definitely enhance the development of human ESC-based therapies for currently untreatable diseases."


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More Than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Scientists Engineer Human Stem Cells and Move Closer to Mastering Regenerative Medicine
Researchers have successfully converted human embryonic stem cells (hESCs) cultured in the laboratory to a state that is closer to the cells found in the human blastocyst.
Wednesday, December 11, 2013
Genome Institute of Singapore and Fluidigm Establish Asia's First Single-Cell Genomics Research Center
Center exclusively dedicated to accelerating the understanding of how individual cells work, and how diagnosis and treatment might be enhanced through insight derived from single cells.
Monday, December 17, 2012
Singapore Scientists Lead in 3D Mapping of Human Genome to Help Understand Human Diseases
This discovery is crucial in understanding how human genes work together, and will re-write textbooks on how transcription regulation and coordination takes place in human cells.
Thursday, February 02, 2012
Scientists’ Genetic Mapping of Han Chinese Provides Invaluable Information of Ethnic Chinese Ancestry
Findings provides invaluable information to determine the design and interpretation of genetic studies of human diseases.
Monday, December 07, 2009
Genome Institute of Singapore and Roche NimbleGen: Tracking the Evolutionary Path of the H1N1 Influenza A
Researchers develop a generic PCR approach to amplify full genome of influenza A virus; followed by NimbleGen microarray-based hybridization sequencing.
Friday, May 29, 2009
Singapore Scientists’ made Significant Discovery for Stem Cell Technology and Clinical Research
Scientists reveal important insights into how researchers can manipulate and engineer different stem cells for the treatment of human degenerative disorders.
Tuesday, September 23, 2008
Scientific News
Liquid Biopsies: Utilization of Circulating Biomarkers for Minimally Invasive Diagnostics Development
Market Trends in Biofluid-based Liquid Biopsies: Deploying Circulating Biomarkers in the Clinic. Enal Razvi, Ph.D., Managing Director, Select Biosciences, Inc.
Self-Assembling, Biomimetic Membranes May Aid Water Filtration
A synthetic membrane that self assembles and is easily produced may lead to better gas separation, water purification, drug delivery and DNA recognition, according to an international team of researchers.
Researchers Discover Immune System’s 'Trojan Horse'
Oxford University researchers have found that human cells use viruses as Trojan horses, transporting a messenger that encourages the immune system to fight the very virus that carries it.
Crystal Clear Images Uncover Secrets of Hormone Receptors
NIH researchers gain better understanding of how neuropeptide hormones trigger chemical reactions in cells.
How Cholesterol Leads to Clogged Arteries
A new study shows that when immune cells called neutrophils are exposed to cholesterol crystals, they release large extracellular web-like structures that trigger the production of inflammatory molecules linked to artherosclerosis.
Genetic Tug of War
Researchers have reported on a version of genetic parental control in mice that is more targeted, and subtle than canonical imprinting.
Ultrafast DNA Diagnostics
New technology developed by UC Berkeley bioengineers promises to make a workhorse lab tool cheaper, more portable and many times faster by accelerating the heating and cooling of genetic samples with the switch of a light.
Researchers Discover New Type of Mycovirus
Virus infects the fungus Aspergillus fumigatus, which can cause the human disease aspergillosis.
Error Correction Mechanism in Cell Division
Cell biologists have reported an advance in understanding the workings of an error correction mechanism that helps cells detect and correct mistakes in cell division early enough to prevent chromosome mis-segregation and aneuploidy, that is, having too many or too few chromosomes.
How to Become a Follicular T Helper Cell
Uncovering the signals that govern the fate of T helper cells is a big step toward improved vaccine design.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!