Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

UCI Launches Effort to Develop Patient-Specific Stem Cell Lines

Published: Tuesday, May 15, 2007
Last Updated: Wednesday, May 16, 2007
Bookmark and Share
UC Irvine neurobiologist Hans Keirstead and his research team launched a project to develop stem cell lines that genetically match human patients.

UC Irvine neurobiologist Hans Keirstead and his research team launched a project to develop stem cell lines that genetically match human patients. These lines would allow scientists to better study conditions ranging from diabetes to Parkinson’s disease, and they would provide the basis for potential patient-specific stem cell treatments.

Keirstead will use a technique called somatic cell nuclear transfer (SCNT) in which a patient’s DNA is transplanted into a donated unfertilized egg cell in order to generate stem cell lines with the same genetic makeup of the patient. These lines have tremendous therapy potential because the human immune system is less likely to attack genetically identical cells. Only a few laboratories in the world are attempting this technique in human stem cell research and, thus far, no human stem cell lines have been derived using this method.

“This technique holds tremendous promise to advance our knowledge of stem cells and their potential to cure disease,” said Keirstead, associate professor of anatomy and neurobiology and co-director of UCI’s Sue and Bill Gross Stem Cell Research Center.

“I am excited to embark on this line of research and look forward to the day when patient-specific stem cells are utilized to treat people suffering from debilitating injuries and health conditions,” he said.

This project received approval May 11 from UCI’s Institutional Review Board, which under federal regulation reviews all proposed studies involving human tissue. The Embryonic Stem Cell Research Oversight Committee at UCI also has reviewed the project and will ensure that experiments involving embryonic stem cells serve important research goals and are conducted according to the highest ethical standards.

UCI has built a workstation that is custom-designed for SCNT experiments. Designed by Gabriel Nistor, a scientist in Keirstead’s laboratory, the quarter-million dollar system housed at the Sue and Bill Gross Stem Cell Research Center will allow scientists to dissect single cells using lasers, manipulate cells using robotic instruments, and control the climate in the work area.

Nistor collaborated with scientists at West Coast Fertility Centers' Embryology Laboratory to design the system. From this Orange County medical practice, Keirstead plans to obtain donated egg cells for his SCNT research.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More Than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Stem Cells Restore Mobility in Neck-Injured Rats
UCI study supports expansion of human trial to include those with cervical spinal cord damage.
Tuesday, November 10, 2009
UCI Discovers New Alzheimer's Gene
UC Irvine study has found that a gene called TOMM40 appears twice as often in people with Alzheimer's disease than in those without it.
Monday, August 17, 2009
Stem Cells can Improve Memory after Brain Injury
Neural stem cells work by protecting existing cells and promoting neuronal connections.
Friday, November 02, 2007
Scientific News
Food Triggers Creation of Regulatory T Cells
IBS researchers document how normal diet establishes immune tolerance conditions in the small intestine.
Light Signals from Living Cells
Fluorescent protein markers delivered under high pressure.
Counting Cancer-busting Oxygen Molecules
Researchers from the Centre for Nanoscale BioPhotonics (CNBP), an Australian Research Centre of Excellence, have shown that nanoparticles used in combination with X-rays, are a viable method for killing cancer cells deep within the living body.
Therapeutic Approach Gives Hope for Multiple Myeloma
A new therapeutic approach tested by a team from Maisonneuve-Rosemont Hospital (CIUSSS-EST, Montreal) and the University of Montreal gives promising results for the treatment of multiple myeloma, a cancer of the bone marrow currently considered incurable with conventional chemotherapy and for which the average life expectancy is about 6 or 7 years.
Cellular 'Relief Valve'
A team led by scientists at The Scripps Research Institute (TSRI) has solved a long-standing mystery in cell biology by showing essentially how a key “relief-valve” in cells does its job.
Genomic Signature Shared by Five Types of Cancer
National Institutes of Health researchers have identified a striking signature in tumor DNA that occurs in five different types of cancer.
Protein Protects Against Flu in Mice
The engineered molecule doesn’t provoke inflammation and may hail a new class of antivirals.
Cat Stem Cell Therapy Gives Humans Hope
By the time Bob the cat came to the UC Davis veterinary hospital, he had used up most of his nine lives.
Crowdfunding the Fight Against Cancer
From budding social causes to groundbreaking businesses to the next big band, crowdfunding has helped connect countless worthy projects with like-minded people willing to support their efforts, even in small ways. But could crowdfunding help fight cancer?
Switch Lets Salmonella Fight, Evade Immune System
Researchers at the University of Illinois at Chicago have discovered a molecular regulator that allows salmonella bacteria to switch from actively causing disease to lurking in a chronic but asymptomatic state called a biofilm.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!