Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Gene may Hold Key to Future Cancer Hope

Published: Tuesday, October 09, 2007
Last Updated: Tuesday, October 09, 2007
Bookmark and Share
The University of Manchester research has identified a key gene that appears to play a critical role in the normal process of cell division.

Scientists may have discovered a new way of killing tumors in what they hope could one day lead to alternative forms of cancer treatments.

The University of Manchester research has identified a key gene that appears to play a critical role in the normal process of cell division.

Cells divide creating new cells as part of the body's natural growth, renewal and healing processes but cancer results when cells divide in an uncontrolled way.

What the Manchester team has discovered is that a protein in our cells called 'Bub 1' is essential for normal cell division to take place; if the gene that generates Bub 1 is 'switched off' then the cells are unable to divide successfully.

"Bub 1 is an enzyme that controls several processes required for cell division to occur," said Dr Stephen Taylor, who led the research in the Faculty of Life Sciences.

"We have shown that mouse embryos lacking the Bub 1 gene are unable to develop. Older cell types also failed to divide when the gene is switched off, while male mice lacking Bub 1 became infertile as their sperm cells died."

In fact, deactivating Bub 1 had such a profound effect on cell division at all stages of a cell's life - known as the 'cell cycle' - that the team is hopeful it will have a similar effect on cancer cells.

"Before cells can divide they have to duplicate and then distribute their genetic material so that the two 'daughter' cells receive all the genetic information for further growth and development," said Dr Taylor, whose work is funded by the charity Cancer Research UK.

"The distribution phase has to be done with a high degree of accuracy - just one chromosome segregated incorrectly, for instance, leads to Down's syndrome - so the cell has a surveillance mechanism which acts as a brake to delay chromosome segregation until accuracy has been guaranteed."

An important part of this intricate surveillance system is Bub 1. The team found that when the gene is switched off the surveillance mechanism fails and accuracy is lost, resulting in cell death.

Now that scientists understand the precise role of Bub 1 in normal cell division, as well as what goes wrong when the gene is missing, they plan to test their theory on cancer cells.

"Unlike some other genes that become mutated in cancer cells, the Bub 1 gene appears normal indicating that it behaves in exactly the same way in cancer cells as it does in healthy cells.

"If this is the case, then we can be confident that switching it off will stop cancer cells proliferating too. And while our normal cells don't divide that often, cancer cells divide more frequently, so hopefully by targeting Bub1 we will selectively kill cancer cells."

Equally exciting, says Dr Taylor, is the fact that drugs are already being developed that are able to block the actions of Bub 1-type enzymes, known as 'protein kinases'; such kinase blockers or 'inhibitors' are already providing a whole new approach to tackling cancer and Bub1 inhibitors may be another weapon in the oncologist's arsenal.

The research, which began in 1999, is published in the journal Developmental Cell on Tuesday, October 9.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More Than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

New Discovery Sheds Light on Disease Risk
Gaps between genes interact to influence the risk of acquiring disease.
Tuesday, December 01, 2015
Treatment for Rare Bleeding Disorder is Effective
Researchers in Manchester have demonstrated for the first time the relative safety and effectiveness of treatment, eltrombopag, in children with persistent or chronic immune thrombocytopenia (ITP), as part of an international duo of studies.
Wednesday, October 14, 2015
National Graphene Institute Reveals First Results With Industrial Partner
The first official experimental results since the National Graphene Institute (NGI) opened in March have been produced. The novel collaboration between industry and academia is exploring the production of graphene in the first stage of a long-term project.
Friday, October 09, 2015
Developing a Gel that Mimics Human Breast for Cancer Research
Scientists at the Universities of Manchester and Nottingham have been funded to develop a gel that will match many of the biological structures of human breast tissue, to advance cancer research and reduce animal testing.
Thursday, October 08, 2015
New Leukemia Gene Stops Blood Cells ‘Growing Up’
University of Manchester scientists have identified a gene – FOXC1 – that, if switched on, causes more aggressive cancer in a fifth of acute myeloid leukaemia (AML) patients, according to a Cancer Research UK study.
Wednesday, September 16, 2015
Early Detection of Lung Cancer
The University of Manchester has signed a collaboration agreement with Abcodia to perform proteomics studies on a cohort of non-small cell lung cancer cases from the UKCTOCS biobank, with the aim of discovering new blood-based biomarkers for earlier detection of the disease.
Tuesday, August 11, 2015
Molecular Clues to Serious Illnesses to be Explored
The University of Manchester is to lead a new £2.9 million molecular pathology research project to improve diagnosis and treatment of non-cancerous diseases within the NHS.
Friday, July 31, 2015
Molecular Clues to Serious Illnesses to be Explored
The University of Manchester is to lead a new £2.9 million molecular pathology research project to improve diagnosis and treatment of non-cancerous diseases within the NHS.
Tuesday, July 28, 2015
Mould Unlocks New Route to Biofuels
Scientists at The University of Manchester have made an important discovery that forms the basis for the development of new applications in biofuels and the sustainable manufacturing of chemicals.
Monday, July 06, 2015
Gene Variants Show Potential In Predicting Rheumatoid Arthritis Disease Outcomes
Arthritis Research UK-funded scientists at The University of Manchester have identified a new way in which genotyping can be used to predict disease outcomes among sufferers of rheumatoid arthritis.
Thursday, April 30, 2015
Potential For Prediction Of Progression For Early Form Of Breast Cancer
Scientists in Manchester have identified a way to potentially predict which patients with an early form of breast cancer will experience disease progression.
Friday, April 17, 2015
Surprising Finding In Stroke Research
Scientists at The University of Manchester have made an important new discovery about the brain’s immune system that could lead to potential new treatments for stroke and other related conditions.
Wednesday, March 18, 2015
Current Detection of Gene Mutations Misses People At High Risk Of Cancer
Research on the BRCA gene mutation in the Jewish population shows that the current process of identifying people misses half the people who have the mutation and are at risk of developing cancer.
Tuesday, December 02, 2014
‘Liquid Biopsy’ Offers New Way to Track Lung Cancer
Scientists have shown how a lung cancer patient’s blood sample could be used to monitor and predict their response to treatment.
Wednesday, June 04, 2014
New Insight into Drug Resistance in Metastatic Melanoma
A study by scientists in Manchester has shown how melanoma drugs can cause the cancer to progress once a patient has stopped responding to treatment.
Wednesday, June 04, 2014
Scientific News
Natural Protein Points to New Inflammation Treatment
Findings may offer insight to effective treatments for inflammatory diseases, such as rheumatoid arthritis, psoriasis, and multiple sclerosis.
Genetic Cause of Rare Allergy
Institute has identified a genetic mutation responsible for a rare form of inherited hives induced by vibratory urticaria.
Battery Component Found to Harm Key Soil Microorganism
The material at the heart of the lithium ion batteries that power electric vehicles, laptop computers and smartphones has been shown to impair a key soil bacterium, according to new research.
Keeping Tumor Growth at Bay
Engineers at Washington University in St. Louis found a way to keep a cancerous tumor from growing by using nanoparticles of the main ingredient in common antacid tablets.
Natural Protein Points to New Inflammation Treatment
Findings may offer insight to effective treatments for inflammatory diseases, such as rheumatoid arthritis, psoriasis, and multiple sclerosis.
Mitochondria Shown to Trigger Cell Ageing
An international team of scientists has for the first time shown that mitochondria, the batteries of the cells, are essential for ageing.
Cancer Cells Kill Off Healthy Neighbours
Cancer cells create space to grow by killing off surrounding healthy cells, according to UK researchers working with fruit flies.
Validating the Accuracy of CRISPR-Cas9
IBS Researchers create multiplex Digenome-seq to find errors in CRISPR-Cas9 processes.
Cancer Drug Target Visualized at Atomic Resolution
New study using cryo-electron microscopy shows how potential drugs could inhibit cancer.
Genetic Mechanism Behind Cancer-Causing Mutations
Researchers at Indiana University has identified a genetic mechanism that is likely to drive mutations that can lead to cancer.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!