Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Decoy Makes Sitting Duck of Superbugs

Published: Tuesday, December 04, 2007
Last Updated: Tuesday, December 04, 2007
Bookmark and Share
A DNA-based therapy could slash the development time of new drugs to combat antibiotic resistant superbugs.

Scientists from the John Innes Centre have proven that by taking a short stretch of DNA from a bacterium and delivering it with an existing antibiotic they can switch off antibiotic resistance.

Together with technology transfer company PBL, the scientists have launched a spin-out company, Procarta Biosystems Ltd, to develop the technology.

“The DNA sequence acts as a decoy, disrupting gene expression and blocking resistance”, said Dr Michael McArthur from JIC.

“We are putting genetic information directly into drugs. This is the first application of a DNA based therapy”.

The scientists have also patented a way of discovering decoys in bacteria without necessarily having to know the genes involved. This means they can develop effective new drugs against any bacterium within a couple of years and at a fraction of the normal cost.

The technology can give fresh patent life to existing antibiotics - when combined with a decoy they can be patented as a new drug.

This comes at a time when the number of new antibiotics receiving approval has dramatically declined. Faced with antibiotic resistance the pharmaceutical industry is unlikely to be able to deliver new products.

“Natural resistance will always be hot on the heels of a new antibiotic because they co-evolve”, said Dr McArthur. “Ours’ is not a traditional pharmaceutical approach and provides a completely new challenge to bacteria”.

The technology can also be used to improve the production of antibiotics by bacteria and to produce enzymes and other compounds using bacteria for use in industrial processes.

Many industrial processes are harsh and unsustainable, using petrochemicals, high temperatures and creating toxic by-products. In industrial biotechnology, also called “white biotechnology”, bacteria make medically and commercially important compounds biologically.

“By using bacteria, many industrial processes could be cleaned up”, said Dr McArthur.

The Procarta scientists found that the bacterium Streptomyces produces a particularly high yield of enzymes and proteins. Unusually, it can also secrete the proteins it produces so they do not have to be extracted.

“Streptomyces is the enzyme producing bacterium with bells and whistles, set to make a major contribution to a market already predicted to be worth £400 million by 2010”, said Dr McArthur.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More Than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Plant-Based Vaccine Among Front Runners In Search For New Polio Jab
A researcher from Norwich is part of a consortium that has been awarded $1.5 million to develop safer polio vaccines, using a new technique developed at the John Innes Centre.
Wednesday, June 15, 2016
Breeding More Climate Resilient Brassicas
Scientists at the John Innes Centre have discovered how a gene that helps determine plant flowering time could help us breed better brassicas in the face of climate change.
Friday, June 03, 2016
Super Wheat Brought Closer to Reality
Scientists at the John Innes Centre (JIC) and The Sainsbury Laboratory (TSL) have pioneered a new gene-detecting technology which, if deployed correctly could lead to the creation of a new elite variety of wheat with durable resistance to disease.
Tuesday, April 26, 2016
Flu Sends Scientists Dipping for Gold
Researchers on the Norwich Research Park have patented a quick, simple dipstick flu test using sugar labelled with gold.
Wednesday, December 11, 2013
“Growing” Medicines in Plants Requires new Regulations
Scientists say amending an EU directive on GMOs could help stimulate innovation in making cheaper vaccines, pharmaceuticals and organic plastics using plants.
Wednesday, February 20, 2013
New Method for Associating Genetic Variation With Crop Traits
A new technique will allow plant breeders to introduce valuable crop traits even without access to the full genome sequence of that crop.
Tuesday, July 24, 2012
Major Grant from Gates Foundation to UK Center to Develop Self-Fertilizing Crops for the Developing World
The John Innes Centre in UK will lead a $9.8m research project to investigate whether it is possible to initiate a symbiosis between cereal crops and bacteria. The symbiosis could help cereals access nitrogen from the air to improve yields.
Monday, July 16, 2012
Plant Research Reveals New Role for Gene Silencing Protein
A DICER protein, known to produce tiny RNAs in cells, also helps complete an important step in gene expression, according to research on Arabidopsis thaliana.
Friday, March 30, 2012
Genomics unlocks key to Mendel's pea flowers
John Innes Centre scientists have helped discover the key to one of biology's most well-known experiments - the gene that controls pea flower colour, used by Gregor Mendel in his initial studies of inheritance.
Wednesday, October 13, 2010
UK: Norfolk GM potato trial withstands blight
A trial plot of genetically-modified potatoes at Norfolk's John Innes Centre has withstood five days of intense late-blight infection.
Thursday, August 26, 2010
Scientific News
Point of Care Diagnostics - A Cautious Revolution
Advances in molecular biology, coupled with the miniaturization and improved sensitivity of assays and devices in general, have enabled a new wave of point-of-care (POC) or “bedside” diagnostics.
Mass Spec Technology Drives Innovation Across the Biopharma Workflow
With greater resolving power, analytical speed, and accuracy, new mass spectrometry technology and techniques are infiltrating the biopharmaceuticals workflow.
One Step Closer to Precision Medicine for Chronic Lung Disease Sufferers
A study led by University of North Carolina at Chapel Hill, and National Jewish Health, has provided evidence of links between SNPs and known COPD blood protein biomarkers.
Blood Pressure Drug May Boost Effectiveness of Lung Cancer Treatment
Researchers at Imperial College London have suggested that the blood pressure drug may make a type of lung cancer treatment more effective.
Insight into Eye Diseases
Scientists recreate zebrafish cell regeneration from retinal stem cells in mice.
New Discovery May Benefit Farmers Worldwide
Scientists have shown how a crop-microbe 'team' protect against fungal infection.
Antibodies Paving the Way to HIV Vaccine
Researchers uncover factors responsible for the formation of broadly neutralizing HIV antibodies in humans.
Designing Drugs with a Whole New Toolbox
Researchers develop methods to design small, targeted proteins with shapes not found in nature.
Protein Studies Discover Molecular Secrets
Two protein studies have mapped proteins that reveal the secrets to recycling carbon and healing cells.
Tapping Evolution to Improve Biotech Products
Researchers show how 'ancestral sequence reconstruction' can be used to guide engineering of a blood clotting protein.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!