Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Findings Indicate How Gene Transcription is Controlled in Embryonic Stem Cells

Published: Monday, May 05, 2008
Last Updated: Monday, May 05, 2008
Bookmark and Share
In a report that appears in the journal Nature Cell Biology, BCM researchers explain that association determines fate in embryonic stem cells.

Association determines fate in embryonic stem cells, said Baylor College of Medicine researchers in a report that appears in the current issue of the journal Nature Cell Biology.

"These findings provide models of how the embryonic stem cell is maintained in its flexible state," said Dr. Zhou Songyang, professor of biochemistry and molecular biology at BCM and senior author of the report. "It provides another hint as to how gene transcription is controlled in embryonic stem cells."

One aim of embryonic stem cell research is to understand how the cells determine whether they will keep dividing and maintain a pool of embryonic cells, or start the process of cellular differentiation that results in different cell types.

Songyang and his colleagues found that two critical embryonic cell proteins – Nanog and Oct4 – associate with specific components that are parts of transcription repression complexes. These complexes affect the way that genes are expressed and carry out their tasks in the cell.

A special complex called NODE (Nanog and Oct4-associated Deacetylase) contains a critical component called Mta1 along with histone deacetylases. NODE associates with Nanog and Oct4 to control the fate of embryonic stem cells, said Songyang.

Histones are critical parts of genomic DNA structures or chromatins, acting as "spools" around which the genetic material winds in the nucleus. The DNA wraps more tightly when deacetylase removes the acetyl tails from the histones. The tight wrapping makes it hard for genes to be transcribed into the message that allows them to carry out their roles in the cell.

"Think of it as the parts of a car," said Songyang.

"If you think of Nanog as the engine that drives it, you realize that the car still needs accessories like wheels, the tailpipe, etc. We are interested in the big machinery of which proteins (like Nanog) are the drivers. We want to understand the enzymatic activities of the complexes. Then we need to identify the individual parts and ask the big question: 'How do different parts work together and why do you need special parts?'”

"We noticed that there are many histone deacetylases," he said. "Nanog uses these proteins to control gene expression and maybe also the chromatin state. When there is deacetylation, the gene is in a passive state."

"The embryonic stem cell is always at the stage of deciding whether to divide (and make more embryonic stem cells) or to differentiate," Songyang said. "All the extrinsic and intrinsic signals make the life of the embryonic stem cell transient. In other words, it has to be ready to go down either road."

"It becomes an interesting question," said Songyang. "Such a demanding state of readiness may mean that the embryonic stem cell requires a different complex at the chromatin than the somatic (or differentiated cell)."


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More Than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Antibodies Block Norovirus’ Entrance into Cells
Scientists have uncovered a mechanism in the human body that targets and successfully blocks noroviruses.
Tuesday, September 20, 2016
Growing Noroviruses in the Lab
Human noroviruses – the leading viral cause of acute diarrhea around the world – have been difficult to study because scientists had not found a way to grow them in the lab.
Tuesday, August 30, 2016
Neurodvelopmental Disorder Cause Linked to SON Gene
A genetic link has been discovered for a previously unxplained neurodevelopmental disorder.
Tuesday, August 23, 2016
Myeloid-Derived Suppressor Cells Play Role in Tumor Growth
Researchers at Baylor College of Medicine have reported a new mechanism that helps cancer cells engage myeloid-derived suppressor cells.
Friday, May 20, 2016
Largest Genomic Study on Kidney Cancer
Understanding the complexity of cancer is a major goal of the scientific community, and for kidney cancer researchers this goal just got closer.
Wednesday, March 16, 2016
Largest Genomic Study on Kidney Cancer Brings Hope for More Effective Treatments
Researchers at Baylor College of Medicine have found that a pathway called immune checkpoint was most active in a subtype of clear cell kidney cancer that is typically very aggressive.
Tuesday, March 08, 2016
Baylor, DNAnexus Collaborate
Partnership sets out to develop HgV, a new iteration of HGSC's Mercury, a BCM-developed data processing and variant calling pipeline for analyzing and annotating next-generation sequencing data in research and clinical contexts.
Tuesday, June 23, 2015
Baylor, TGen Collaborate on Personalized Cancer Treatment Options
The companies will collaborate on precision medicine for cancer patients by offering liquid biopsies, performing gene sequencing, conducting clinical trials, and creating personalized vaccines.
Tuesday, May 26, 2015
Role of Cancer Stem Cells in Chemo-Resistance
'Wound response' of cancer stem cells may explain chemo-resistance in bladder cancer.
Friday, December 05, 2014
Massimo Pietropaolo Named McNair Scholar at Baylor
World renowned physician-scientist in type 1 diabetes research, Dr. Massimo Pietropaolo, has been named McNair Scholar at Baylor College of Medicine.
Wednesday, October 29, 2014
Clinical Integration of NGS
Experts provide much-needed policy analysis for clinical integration of next generation sequencing.
Tuesday, September 23, 2014
Collaboration Unravels Novel Mechanism for Neurological Disorder
The novel gene (CLP1) associated with a neurological disorder affecting both the peripheral and central nervous systems.
Saturday, April 26, 2014
$3M NIH Grant Enables Baylor International HIV/AIDS Program
Researchers to study genetic differences of disease in sub-Saharan African children.
Wednesday, February 19, 2014
Baylor College of Medicine, Berry Genomics Co. Seek to Improve on Prenatal Genetic Tests
Teams aim to improve prenatal genetic testing by combining BCM’s expertise in using microarrays for DNA analysis and Berry’s non-invasive technology evaluating fetal DNA in maternal plasma.
Monday, January 07, 2013
Microarray Analysis Improves Prenatal Diagnosis
A "chip" or array that can quickly detect disorders such as Down syndrome, or other diseases associated with chromosomal abnormalities, has proved an effective tool in prenatal diagnosis in 300 cases, as reported by Baylor College of Medicine.
Tuesday, November 29, 2011
Scientific News
Mass Spec Technology Drives Innovation Across the Biopharma Workflow
With greater resolving power, analytical speed, and accuracy, new mass spectrometry technology and techniques are infiltrating the biopharmaceuticals workflow.
One Step Closer to Precision Medicine for Chronic Lung Disease Sufferers
A study led by University of North Carolina at Chapel Hill, and National Jewish Health, has provided evidence of links between SNPs and known COPD blood protein biomarkers.
Gene Regulation in Brain May Explain Repetitive Behaviors in Rett Syndrome Patients
The research could be a key step in developing treatments to eliminate symptoms that drastically impair the quality of life in Rett patients.
Heart Arrhythmia Caused by Mosaic of Mutant Cells
Researchers have solved the genetic mystery of an infant suffering from heart arrhythmia.
Iron Nanoparticles Make Immune Cells Attack Cancer
Researchers accidentally discover that nanoparticles invented for anemia treatment can trigger the immune system’s ability to destroy tumor cells.
Crispr Toolbox Expanded By Protein
Researchers have shown a newly discovered CRISPR protein has two distinct RNA cutting activities.
CES Score May Predict Response to Cancer Treatment
Researchers identify new type of biomarker that helps predict prognosis and response to several types of cancer treatment.
Uncovering Cancer’s ‘Invisibility Cloak’
Researchers discover cancer cell mechanism to become invisible to the body's immune system.
Genetic Impact of Endurance Training
Research has found that endurance training changes genetic activity in thousands of genes, giving rise to large number of altered RNA variants.
Treating Sepsis with Marine Mitochondria
Mitochondrial alternative oxidase from a marine animal combats bacterial sepsis.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!