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Defining new standards for qPCR machines...4titude® Ltd. - Manufacturing & Quality ...PerkinElmer chemagic 360...

Featured Products
Featured ProjectAccuPrep GMO DNA Extraction Kit
AccuPrep GMO DNA Extraction Kit
Featured ProjectQIAGEN’s Liquid Biopsy Portfolio – from Sample to Insight
QIAGEN’s Liquid Biopsy Portfolio – from Sample to Insight

Webcasts
The Bru-seq Technology Platform for Nascent RNA analysisThe Bru-seq Technology Platform for Nascent RNA analysis
Mats Ljungman, Professor, University of Michigan will present a set of novel techniques to analyze many aspects of gene expression based on the capturing of nascent RNA.
Drug Sensitivity and Resistance Testing Platform for Personalized Medicine at the Institute for Molecular Medicine Finland (FIMM)Drug Sensitivity and Resistance Testing Platform for Personalized Medicine at the Institute for Molecular Medicine Finland (FIMM)
Jani Saarela, Institute for Molecular Medicine, speaking at Screening Europe 2015

Market Reports
The Future of Molecular Diagnostics: Innovative technologies driving market opportunities in personalized medicine
Business Insights

This report analyzes the current and potential world markets for molecular diagnostics, including advances in the field. This report generally forecasts future growth to 2015. The report breaks down market forecasts by type of test and by geography. It indicates which companies have key products in the market place. It also analyzes key drivers of this market.
Scientific News
New Inflammatory Disease Discovered
NIH researchers have discovered a rare and potentially deadly disease - otulipenia - the mostly affects children.
Bringing NGS to the Crime Lab
New technology being validated in BCI lab for use in Ohio missing persons cases.
Expanding Knowledge of Viral Diversity
Environmental datasets help researchers double the number of microbial phyla known to be infected by viruses.
How Cloud Connectivity Can Combat the Reproducibility Crisis
This infographic explains the reproducibility crisis, and how cloud connectivity can help overcome this problem.
The Power of Model Systems
New insights into the influence of host on the gut microbiome are revealed with in situ light sheet fluorescence microscopy and stochastic mathematical modelling.
New Way To Measure Important Chemical Modification On RNA
Technology could advance stem cells’ use in regenerative medicine, UCLA researchers say.
Mapping Antibody Creation in Humans
Researchers have created the first, detailed map of the body's antibody production, which could suggest new treatment options for immune disorders.
Decoding the Genome of the Olive Tree
A team of scientists from three Spanish centers has sequenced, for the first time ever, the complete genome of the olive tree. This work will facilitate genetic improvement for production of olives and olive oil, two key products in the Spanish economy and diet.
Four Newly-Identified Genes Could Improve Rice
A Japanese research team have applied a method used in human genetic analysis to rice and rapidly discovered four new genes that are potentially significant for agriculture. These findings could influence crop breeding and help combat food shortages caused by a growing population.
What Makes a Good Scientist?
It’s the journey, not just the destination that counts as a scientist when conducting research.
Business News
Illumina Accelerator Welcomes First International Fellow
Illumina Accelerator has expanded their startup pool with the Center of Individualized Diagnostics (CID).
IBO Announces Industrial Design Award Winners
IBO announced their Industrial Design Awards winners in three separate award categories.
Cancer Genetics Receives NY State Approval for Myeloid™
Myeloid™ is a unique NGS panel for improved diagnosis, prognosis, therapy selection, and risk stratification of myeloid cancer patients.
BioNano Genomics, Berry Genomics Collaborate
Collaboration aims to develop next-generation mapping system for CFDA-approved clinical use in china.
Illumina, FlowJo Partner
Companies to develop software for analysis and reporting of single cell data will advance research into cell function, disease progression, and therapeutic response.
ArcherDX NGS Assays Receive Conditional Approval by NY State
The NGS based assays will be used to identify known and novel gene fusions in blood cancers, sarcomas, and solid tumors.
PGDx, Illumina Collaborate
Collaboration aims to develop cancer in vitro diagnostic test kits.
SomaGenics, Rubicon Announce Agreement
Collaboration aims to commercialize SomaGenics’ RealSeq®-AC technology for high-throughput sequencing of small RNAs.
SomaGenics Licenses Rights to Rubicon Genomics
SomaGenics Inc. has licensed rights of its RealSeq-AC Technology to Rubicon Genomics.
NantHealth, University of Utah Announce Partnership
Partnership aims to establish heritage 1K project to discover genetic causes of 25 rare and common diseases.

Events
Food Safety & Analysis Congres
06 Sep 2016
Food Safety & Analysis Congres ...
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4th Plant Genomics Congress US
12 Sep 2016
4th Plant Genomics Congress US ...
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2nd International Conference o
12 Sep 2016
2nd International Conference o ...
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Pipette calibrations: Don
20 Sep 2016
Pipette calibrations: Don't ri ...
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ePosters
Experimental design considerations for efficient and specific gene knockin using a CRISPR-Cas9 for HDR with synthetic crRNA and tracrRNA
Dharmacon, part of GE Healthcare

Precise genome engineering with CRISPR-Cas9 and single-stranded DNA oligo or double-stranded DNA plasmid donors via homology-directed repair (HDR).
CRISPR-Cas9 genome editing utilizing chemically synthesized RNA
Dharmacon (part of GE Healthcare)

CRISPR-Cas9 gene editing using synthetic crRNA:tracrRNA or sgRNA is highly efficient and easy to use. Synthetic crRNA:tracrRNA is uniquely suited to in vitro and in vivo applications, in particular, DNA-free approach with Cas9 mRNA. Chemical synthesis of guide RNAs allows accurate and rapid production of arrayed crRNA libraries for high-confidence, loss-of-function screens.
Advanced Microfluidic Mixing Device for the Study of Macromolecule Dynamics
Department of Biomedical, IIT Hyderabad

We have developed and characterized a micro-fluidic mixer to study the macro-molecule dynamics such as kinetics of protein folding, DNA sequencing, single molecule study and detection etc. on a micro-second timescale. Numerical simulation has been performed to analyse the study of mixing performance of micro-fluidics channel.
DNA-free CRISPR-Cas9 genome engineering in zebrafish
Dharmacon (part of GE Healthcare)

Poster describing the advantages of a DNA-free gene editing system and the application of this system in zebrafish.
600 base reads on the Ion S5™ Next-Generation Sequencing System enables accurate HLA typing of 96 samples on one 530™ chip
Thermo Fisher Scientific, 5791 Van Allen Way, Carlsbad, CA, USA, 92008

We have demonstrated that by combining improvements in templating and sequencing biochemistry we are able to sequence templates longer than 600 bases with high accuracy on an Ion S5 530 chip.
These improvements open the S5 use space to include haplotyping applications that require longer reads. As a demonstration of that, we accurately typed 96 HLA samples on one 530 chip.
Addressing False Positive Variants Arising from Pseudogenes
1National Heart and Lung Institute, Imperial College, London, UK, 2NIHR Cardiovascular BRU, Royal Brompton and Harefield NHS Trust, London, UK, 3Royal Brompton and Har

Clinical genetic testing has been transformed in recent years by the introduction of Next-Generation Sequencing (NGS).
Design considerations for highly specific and efficient synthetic crRNA molecules
GE Healthcare Dharmacon, Inc.

An overview of our rational design algorithm for picking highly functional crRNA sequences in combination with comprehensive specificity analysis.
Picking the best CRISPR-Cas9 targets for functional gene knockout: a machine learning algorithm based on both specificity and functionality
GE Healthcare Dharmacon, Inc.

The CRISPR-Cas9 system has the potential to significantly advance basic and applied research.
Scaffold design, function and over-expression of lentiviral-based microRNAs
GE Healthcare Dharmacon, Inc.

Here we describe the strategy for scaffold design, the importance of an optimal promoter, and demonstrate gene target down-regulation from the over-expression of lentiviral microRNA mimics.
Homology-directed repair with Dharmacon™ Edit-R™ CRISPR-Cas9 and single-stranded DNA oligos
GE Healthcare Dharmacon, Inc.

Here we demonstrate how to perform lipid based transfections for homology directed repair using DharmaFECT Duo, CRISPR-Cas9 reagents and, synthetic DNA donor oligos.
Application Notes
Automated Low-volume DNA Normalisation and NGS Library Prep for Single-cell Analysis
ttp labtech

This application note presents data from Prof. Stephen Quake’s lab, Stanford University, USA on the use of TTP Labtech’s automated low-volume liquid handlers for miniaturising DNA normalisation and library prep volumes for singlecell analysis.
Reduced-Bias Small RNA Library Preparation with Gel-Free or Low-Input Options
Bioo Scientific

Changes in microRNA (miRNA) expression have been shown to be associated with a variety of normal physiological processes, as well as diseases including cancer. Studies have already shown that miRNAs may provide useful markers for the development of disease diagnostic and prognostic assays.
Improved Library Prep Offers Higher Percentage of On-target Reads and Better Coverage for SureSelectXT2 Target Capture
Bioo Scientific

The seamless compatibility between the NEXTflex Pre- and Post- Capture library preparation kit and all reagents required for target capture using Agilent’s SureSelectXT2 bait set is demonstrated.
Directional qRNA-Seq: Combining the Power of Stranded RNA-Seq with the Quantitative Precision of Molecular Labels
Bioo Scientific

Bioo Scientific introduces a novel product for advanced RNA-Seq library preparation that features strand-specific RNA sequencing and correction of PCR amplification bias by molecular indexing: the NEXTflex™ Rapid Directional qRNA-Seq™ Kit.
Approaching Single-Cell Sequencing by Understanding NGS Library Complexity and Bias
Swift Biosciences Inc

This application note describes the sequence coverage performance andp reservation of molecular complexity of next generation sequencing (NGS) libraries generated from human and microbial genomic DNA using the Accel-NGS™ 2S DNA Library Kit for whole-genome sequencing (WGS) on the Illumina® platform.
Automated Illumina TruSeq® Nano DNA Sample Preparation
Tecan Group Ltd.

The TruSeq Nano DNA Sample Preparation Kit enables efficient investigation of samples where the amount of DNA available is limited. This low-input method generates excellent quality data from as little at 100 ng of DNA, allowing the study of samples with restricted DNA availability, for example from tumors, and helping to preserve precious sample material for use in future studies.
Double stranded DNA quantitation using Promega QuantiFluor® Dyes
Tecan Group Ltd.

Achieving selective and sensitive quantitation of double stranded DNA (dsDNA) using spectrophotometric methods can be problematic. Recognizing these difficulties, researchers have incorporated fluorescence-based quantitation techniques in their workflows to obtain the required sensitivity and target selectivity.
Automated Illumina NGS Sample Preparation: TruSeq® Stranded mRNA on the Hamilton Microlab STAR
Hamilton Robotics

Illumina’s sample preparation kits produce high quality libraries for DNA and RNA sequencing. Hamilton offers the robust Microlab STAR line of robotic liquid handling workstations for automating sample preparation. Together, the automation of the TruSeq Stranded mRNA sample preparation protocol on the STAR gives the user hours of reliable, unattended library preparation.
Molecular indexing for improved RNA-Seq analysis
Bioo Scientific

Most modern methods for nucleic acid analysis require the use of enzyme processing, such as DNA polymerase reactions, in the sample preparation or measurement steps. Although necessary, these enzymatic steps introduce errors in the form of incorrect sequence and misrepresented copy number. NEXTflex™ qRNA-Seq™ Kit from Bioo Scientific adds no additional steps to the work flow, costs no more than a conventional library preparation kit and increases the precision of downstream analysis.
An Integrated Solution to Simplify Library Preparation and Multiplexing for NimbleGen Sequence Capture
Bioo Scientific

The studies described herein demonstrate the capability of Bioo Scientific’s novel NEXTFlex™ DNA Pre-Capture Combo Library construction kits used in conjunction with the NimbleGen Sequence Capture technology to obtain high coverage comparative genomic data from a panel of human HapMap DNA samples.
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