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Featured Products
Featured ProjectAccuPrep GMO DNA Extraction Kit
AccuPrep GMO DNA Extraction Kit
Featured ProjectMantis For Next-Gen Sequencing Library Prep
Mantis For Next-Gen Sequencing Library Prep

Webcasts
The Bru-seq Technology Platform for Nascent RNA analysisThe Bru-seq Technology Platform for Nascent RNA analysis
Mats Ljungman, Professor, University of Michigan will present a set of novel techniques to analyze many aspects of gene expression based on the capturing of nascent RNA.
Drug Sensitivity and Resistance Testing Platform for Personalized Medicine at the Institute for Molecular Medicine Finland (FIMM)Drug Sensitivity and Resistance Testing Platform for Personalized Medicine at the Institute for Molecular Medicine Finland (FIMM)
Jani Saarela, Institute for Molecular Medicine, speaking at Screening Europe 2015

Market Reports
The Future of Molecular Diagnostics: Innovative technologies driving market opportunities in personalized medicine
Business Insights

This report analyzes the current and potential world markets for molecular diagnostics, including advances in the field. This report generally forecasts future growth to 2015. The report breaks down market forecasts by type of test and by geography. It indicates which companies have key products in the market place. It also analyzes key drivers of this market.
Scientific News
Monovar Drills Down Into Cancer Genome
Rice, MD Anderson develop program to ID mutations in single cancer cells.
Five New Breast Cancer Genes Found
Discovery of mutations paves the way for personalised treatment of breast cancer.
New Neurodevelopmental Syndrome Identified
Study pinpoints underlying genetic mutations, raising hopes for targeted therapies.
Uncovering Hidden Genomic Alterations that Drive Cancers
Tested on large tumor genomics database, REVEALER method allows researchers to connect genomics to cell function.
Gene Behind Rare Childhood Syndrome Identified
Online activism by one patient’s mother spurred research collaboration which led to the identification of a new genetic syndrome.
Resilience Project Identifies Rare Unaffected Individuals
Researchers from Mount Sinai and Sage Bionetworks report analysis of nearly 600,000 genomes for resilience project.
Rare DNA Will Have Nowhere To Hide
Two National Institutes of Health grants back Rice University effort to develop new diagnostics.
Virus Causing Tilapia Die-Offs Identified
Discovery of the virus causing Tilapia die-offs in Israel and Ecuador points the way to protecting a fish that feeds multitudes.
Children With Cancer To Get New Gene Test
Pilot study will sequence 81 cancer genes in children’s tumours to help personalise cancer treatment.
How The Bat Got Its Wings
Finding may provide clues to human limb development and malformations.
Business News
TBUSA, IDT Announce Collaboration
Collaboration aims to support targeted RNA Sequencing.
TATAA Biocenter, Lexogen Announce Strategic Partnership
Company has announced partnership with Lexogen to distribute Lexogen’s NGS products.
Takara Bio, Integrated DNA Technologies Collaborate
Life science companies combine expertise to enhance transcriptome research.
Illumina Files Patent Infringement Suit against Genoma SA
Company has announced that it has filed a patent infringement suit against Genoma SA in the Switzerland for Infringement of NIPT Patents.
SeraCare, TOMA Biosciences Announce Partnership
Collaboration aims to provide Seraseq™ biosynthetic reference material technology in development and validation of the TOMA OS-Seq™ reagent kits.
Novogene Establishes Genomic Sequencing Center at UC Davis
Novogene has announced that it has established its first genomics sequencing center in the United States, located on the Sacramento campus of the University of California, Davis.
Illumina Invests In New Venture Fund
Illumina will commit $100M over 10 years to drive genomic technology development.
N-of-One Selected by Admera to Provide Clinical Interpretation
Company has announced that it has selected by Admera to provide clinical interpretation of their 64-gene oncology panel, OncoGxOne™.
HTG Announces Distribution Agreements with Gamidor and Durviz
Company has announced distribution agreements with Gamidor and Durviz to manage distribution of HTG’s next generation sequencing (NGS)-based products.
Genestack to Collaborate with CMDL
Company has announced collaboration with CDML to bring advanced genomic technologies into clinical practice.

Events
Plant Genomics Congress
09 May 2016
Plant Genomics Congress ...
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EMBO | EMBL Symposium: New Mod
08 May 2016
EMBO | EMBL Symposium: New Mod ...
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6th Next Generation Sequencing
25 May 2016
6th Next Generation Sequencing ...
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Genomic Applications of qPCR,
26 May 2016
Genomic Applications of qPCR, ...
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ePosters
Advanced Microfluidic Mixing Device for the Study of Macromolecule Dynamics
Department of Biomedical, IIT Hyderabad

We have developed and characterized a micro-fluidic mixer to study the macro-molecule dynamics such as kinetics of protein folding, DNA sequencing, single molecule study and detection etc. on a micro-second timescale. Numerical simulation has been performed to analyse the study of mixing performance of micro-fluidics channel.
Addressing False Positive Variants Arising from Pseudogenes
1National Heart and Lung Institute, Imperial College, London, UK, 2NIHR Cardiovascular BRU, Royal Brompton and Harefield NHS Trust, London, UK, 3Royal Brompton and Har

Clinical genetic testing has been transformed in recent years by the introduction of Next-Generation Sequencing (NGS).
Design considerations for highly specific and efficient synthetic crRNA molecules
GE Healthcare Dharmacon, Inc.

An overview of our rational design algorithm for picking highly functional crRNA sequences in combination with comprehensive specificity analysis.
Picking the best CRISPR-Cas9 targets for functional gene knockout: a machine learning algorithm based on both specificity and functionality
GE Healthcare Dharmacon, Inc.

The CRISPR-Cas9 system has the potential to significantly advance basic and applied research.
Scaffold design, function and over-expression of lentiviral-based microRNAs
GE Healthcare Dharmacon, Inc.

Here we describe the strategy for scaffold design, the importance of an optimal promoter, and demonstrate gene target down-regulation from the over-expression of lentiviral microRNA mimics.
Homology-directed repair with Dharmacon™ Edit-R™ CRISPR-Cas9 and single-stranded DNA oligos
GE Healthcare Dharmacon, Inc.

Here we demonstrate how to perform lipid based transfections for homology directed repair using DharmaFECT Duo, CRISPR-Cas9 reagents and, synthetic DNA donor oligos.
Increasing gene editing efficiencies in eukaryotic cell lines by selection of appropriate CRISPR-Cas9 reagents
GE Healthcare Dharmacon, Inc.

Overview of various CRISPR-Cas9 reagents to provide the highest efficiency of gene editing in your experiments.
Knockdown of p53 by Accell self-delivering siRNA causes inhibition of p53-dependent DNA damage response in IMR-32 neuroblastoma cell line and β-amyloid toxicity in rat cortical neurons
GE Healthcare Dharmacon, Inc.

Here we describe how application of Accell siRNA enabled the development of a high content screening assay in IMR-32 neuroblastoma cells and a whole culture cell viability assay in primary rat cortical neurons.
An Efficient Method for the Incorporation of Molecular Probes at Multiple/Specific sites in RNA: Levulinyl Protection for 2'-ACE ® , 5'-Silyl Oligoribonucleotide Synthesis
GE Healthcare Dharmacon, Inc.

A unique method that uses a levulinate ester as a protecting group to introduce conjugates or molecular probes to virtually any location in a synthetic RNA molecule is discussed. The Levulinyl protecting group is stable in RNA synthesis conditions and can be removed without affecting the other parts of the synthesized RNA. We show the capabilities of this approach with three high-complexity synthesis examples.
Acoustophoretic microfluidic device for high throughput DNA sequencing
Dept. of Biomedical Engineering IIT Hyderabad

Multiphysics modelling for acoustic standing wave technology combined with micro-technology which can be used for manipulation and concentration on typical Lab-on-Chip devices for DNA sequencing.
Application Notes
Reduced-Bias Small RNA Library Preparation with Gel-Free or Low-Input Options
Bioo Scientific

Changes in microRNA (miRNA) expression have been shown to be associated with a variety of normal physiological processes, as well as diseases including cancer. Studies have already shown that miRNAs may provide useful markers for the development of disease diagnostic and prognostic assays.
Improved Library Prep Offers Higher Percentage of On-target Reads and Better Coverage for SureSelectXT2 Target Capture
Bioo Scientific

The seamless compatibility between the NEXTflex Pre- and Post- Capture library preparation kit and all reagents required for target capture using Agilent’s SureSelectXT2 bait set is demonstrated.
Directional qRNA-Seq: Combining the Power of Stranded RNA-Seq with the Quantitative Precision of Molecular Labels
Bioo Scientific

Bioo Scientific introduces a novel product for advanced RNA-Seq library preparation that features strand-specific RNA sequencing and correction of PCR amplification bias by molecular indexing: the NEXTflex™ Rapid Directional qRNA-Seq™ Kit.
Approaching Single-Cell Sequencing by Understanding NGS Library Complexity and Bias
Swift Biosciences Inc

This application note describes the sequence coverage performance andp reservation of molecular complexity of next generation sequencing (NGS) libraries generated from human and microbial genomic DNA using the Accel-NGS™ 2S DNA Library Kit for whole-genome sequencing (WGS) on the Illumina® platform.
Automated Illumina TruSeq® Nano DNA Sample Preparation
Tecan Group Ltd.

The TruSeq Nano DNA Sample Preparation Kit enables efficient investigation of samples where the amount of DNA available is limited. This low-input method generates excellent quality data from as little at 100 ng of DNA, allowing the study of samples with restricted DNA availability, for example from tumors, and helping to preserve precious sample material for use in future studies.
Double stranded DNA quantitation using Promega QuantiFluor® Dyes
Tecan Group Ltd.

Achieving selective and sensitive quantitation of double stranded DNA (dsDNA) using spectrophotometric methods can be problematic. Recognizing these difficulties, researchers have incorporated fluorescence-based quantitation techniques in their workflows to obtain the required sensitivity and target selectivity.
Automated Illumina NGS Sample Preparation: TruSeq® Stranded mRNA on the Hamilton Microlab STAR
Hamilton Robotics

Illumina’s sample preparation kits produce high quality libraries for DNA and RNA sequencing. Hamilton offers the robust Microlab STAR line of robotic liquid handling workstations for automating sample preparation. Together, the automation of the TruSeq Stranded mRNA sample preparation protocol on the STAR gives the user hours of reliable, unattended library preparation.
Molecular indexing for improved RNA-Seq analysis
Bioo Scientific

Most modern methods for nucleic acid analysis require the use of enzyme processing, such as DNA polymerase reactions, in the sample preparation or measurement steps. Although necessary, these enzymatic steps introduce errors in the form of incorrect sequence and misrepresented copy number. NEXTflex™ qRNA-Seq™ Kit from Bioo Scientific adds no additional steps to the work flow, costs no more than a conventional library preparation kit and increases the precision of downstream analysis.
An Integrated Solution to Simplify Library Preparation and Multiplexing for NimbleGen Sequence Capture
Bioo Scientific

The studies described herein demonstrate the capability of Bioo Scientific’s novel NEXTFlex™ DNA Pre-Capture Combo Library construction kits used in conjunction with the NimbleGen Sequence Capture technology to obtain high coverage comparative genomic data from a panel of human HapMap DNA samples.
Next Generation Sequencing Method for Illumina TruSeq DNA Sample Preparation Protocol on the Hamilton STAR
Hamilton

The purpose of the TruSeq sample preparation protocol is to add adapter sequences onto the ends of DNA fragments to generate multiplexed sequencing libraries. Good liquid handling is crucial for pipetting precise volumes for example for Agilent Bioanalyzer.
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