Corporate Banner
Satellite Banner
Next Gen Sequencing
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

IDT Launches xGen™ Lockdown™ Probes

Published: Thursday, September 06, 2012
Last Updated: Thursday, September 06, 2012
Bookmark and Share
Scalable target capture probes for Next Generation Sequencing.

Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, now provides xGen™ Lockdown™ Probes individually synthesized 60-120 nucleotide 5’-biotinylated capture oligonucleotides designed to enable cost-effective, high depth sequencing and analysis of specific regions of the genome.

xGen Lockdown Probes are ideal for target enrichment and custom panel development, and capture sets can be easily expanded. Available at three different scales (mini – 2 pmole, standard – 20 pmole, and XL – 200 pmole), users can design their initial capture panels using the mini scale and extend them by progressively supplementing with more probes. As a result, it is quick and simple to transition to higher volume applications.

Whether used with custom capture panels, or for supplementing existing panels, xGen Lockdown Probes provide approximately 5000-fold enrichment with high coverage over targeted regions, and minimal GC bias. Furthermore, the probes can be added to array-derived RNA baits to enhance coverage of GC-rich targets, such as first exons. Users can therefore improve capture performance by rescuing drop-out regions of array-derived exome capture, improve the uniformity of coverage, discover additional genetic mutations, or improve coverage of specific regions of interest without redesigning a new panel.

Each xGen Lockdown Probe is individually synthesised and quality assessed via mass spectroscopy, providing high levels of performance. They are supplied in 96- or 384-well plates, or as pools of up to 2000 oligos. Shipped within 7-10 business days, users can get a quick start on their projects, facilitating the transition from discovery to clinical application.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,400+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Fast and Focused Sequencing from Single Genes to Entire Exomes
IDT reveals how to increase sequencing success with new and existing enrichment panels.
Monday, March 16, 2015
Discover Affordable Custom NGS Panels
IDT webinar helps NGS researchers bring cost-savings to target capture panels.
Thursday, February 12, 2015
Discover the Latest NGS-Based Assays Guiding Precision Oncology
IDT joins forces with Foundation Medicine in AMP workshop.
Saturday, November 08, 2014
IDT Shares Tips for Optimizing Target Capture
The article discusses improved target capture methods for increasing reliability of next generation sequencing data.
Friday, October 24, 2014
From Honey Bees to Hearts - Keep Track of the Latest in NGS
Free IDT symposium explores diverse NGS applications.
Wednesday, September 24, 2014
Enhanced Molecular Inversion Probes for NGS Target Enrichment
IDT presents latest developments at 15th annual Advances in Genome Biology and Technology meeting.
Tuesday, February 04, 2014
Not a Constant Value: Understanding Tm
IDT explains how to optimize oligo hybridization-based protocols.
Friday, December 20, 2013
Bringing NGS to the Clinic: What Can We Expect?
Dr Elaine Mardis shares her views with IDT on the future of NGS and its role in personalized medicine.
Thursday, February 07, 2013
Integrated DNA Technologies Acquires 1st BASE Oligonucleotide Business in Singapore
Already the world leader in custom nucleic acid synthesis, IDT will now offer locally-manufactured oligos to researchers in Singapore and throughout the region from the company’s first synthesis facility in Asia.
Thursday, February 09, 2012
Scientific News
DNA Damage Seen in Patients Undergoing CT Scanning
Along with the burgeoning use of advanced medical imaging tests over the past decade have come rising public health concerns about possible links between low-dose radiation and cancer.
Web App Helps Researchers Explore Cancer Genetics
Brown University computer scientists have developed a new interactive tool to help researchers and clinicians explore the genetic underpinnings of cancer.
New Research Advances Genetic Studies in Wildlife Conservation
‘Next-gen’ DNA sequencing of non-invasively collected hair expands field of conservation genetics.
Gene Testing Now Allows Precision Medicine for Thoracic Aneurysms
Researchers at the Aortic Institute at Yale have tested the genomes of more than 100 patients with thoracic aortic aneurysms, a potentially lethal condition, and provided genetically personalized care.
OGT’s Popular ESHG Workshop Free to View Online
Learn about the next generation of microarrays in one of the best attended workshops of the conference.
Discordant NIPT Test Results May Reflect Presence of Maternal Cancer
Results published in Journal of the American Medical Association.
Sperm RNA Test May Improve Evaluation of Male Infertility
To help resolve uncertainty—and guide prospective parents to the right fertility treatments—scientists propose the use of a new kind of fertility test. It involves examining sperm RNA by means of next-generation sequencing.
How the Mammoth Got its Wool
Evolutionary change in a gene reconstructed in the lab from the woolly mammoth was part of a suite of adaptations that allowed the mammoth to survive in harsh arctic environments, according to new research.
NuGEN Scientists Screen 400+ Genes for Fusion Events in Single Assay
Breakthrough proves efficacy of new sample preparation method that could accelerate cancer research and development of treatments and diagnostic tests.
More Accurate and Comprehensive Whole Genome Assembly
Scientists from the Icahn School of Medicine at Mount Sinai have developed a new approach to build nearly complete genomes by combining high-throughput DNA sequencing with genome mapping.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!