DNASTAR® has announced the release of Lasergene 12, highlighting significant improvements in MegAlign Pro, a multiple sequence alignment application within Lasergene®, and industry-leading accuracy in NGS reference-guided assembly and SNP calling.
Additionally, the release features new, easy-to-use workflows designed for clinical researchers who analyze panels of genes, leveraging human exome or whole human genome data.
MegAlign Pro was initially released as part of Lasergene in the spring of 2013. Improvements to MegAlign Pro included in Lasergene 12 are the MAFFT alignment algorithm, several new analysis and visualization methods, and enhanced phylogenetic tree capability.
The Lasergene Genomics Suite has been dramatically improved in Lasergene 12, with SNP calling accuracy at 99.8% and the introduction of a series of new gene panel workflows. These enhancements will support clinical researchers by integrating VCF and BED (or Manifest) files for Mendelian/Germline and Cancer/Somatic investigations. The Lasergene Genomics Suite has also been enhanced to support SNP validation and control, which many clinical researchers find invaluable to their work.
Tom Schwei, Vice President and General Manager of DNASTAR, said, “DNASTAR has been delivering software to meet the needs in the molecular biology general research software market for the past 30 years. With Lasergene 12, we have continued to enhance our general research offering, while also putting a heavy emphasis on supporting the emerging needs of clinical researchers using Next-Generation Sequencing (NGS) data. The enhancements to MegAlign Pro and improved accuracy of our NGS assembler and SNP caller will serve all markets well, while the gene panel workflows are aimed at serving the clinical research market, which includes many of DNASTAR’s current customers. We are very pleased to continue to meet the needs of a wide range of molecular biologists and other life scientists. We look forward to continuing to broaden our appeal to researchers involved in genomics and related fields through future software releases and updates.”