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Thursday, January 29, 2015
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Geneious R8: A Powerful and Comprehensive Suite of Molecular Biology Tools

Christian Olsen, Kashef Qaadri, Richard Moir, Matt Kearse, Simon Buxton, Matthew Cheung, Hengjie Wang, Jonas Kuhn, Steven Stones-Havas, Chris Duran

Geneious R8: A powerful and comprehensive suite of molecular biology tools.

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Putative Genes Identified on Two Growth Conditions of G. boninense
Jayanthi N, Abrizah O, Low ETL, O-Abdullah M, Hogan M, Cuomo CA, Desjardins C, Abdul Manaf MA, Rajinder S, Birren B and Ravigadevi S

Putative genes identified on two growth conditions of Ganoderma boninense.

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Contrasting Patterns of Neutral and Adaptive Genetic Variation of Chilean Blue Mussel (Mytilus chilensis) Due to Local Adaptation and Aquaculture
Cristian Araneda1 , M. Angelica Larrain2, Benjamin Hecht3, Shawn Narum4

This study was designed to investigate patterns of neutral and adaptive genetic variation within Chilean blue mussel populations in order to identify a subset of putatively adaptive genetic markers to investigate the population structure and to improve the ability to trace individuals to their geographical origin, especially in the area with strong aquaculture activities

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Transcription Factors to Classify Tumor Types and Subtypes
Benjamin Otto 1,2, Kristin Klätschke 2, Thomas Streichert 3, Christoph Wagener 2, Genrich Tolstonog 4

Here we introduce the use of the unsupervised approach to identify transcription factors (TFs) that are specific for different tumor types.

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Identifying Molecular Signatures of Tumors Using Novel Fluorescence Resonance Energy Transfer Networks
Vishwa Nellore, Chris Dwyer

We developed FRET sensors that can detect 125 fluorophores simultaneously. From experimental analyses of over 1200 time-resolved fluorescence signatures on 300 prototypical sensors, we show that the optical responses are highly repeatable and minor variations between FRET networks can be discriminated resulting in a total of 10^375 unique responses in theory.

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NEXTflex™ qRNA-Seq™ Molecular Indexing for ChIP-Seq and RNA-Seq
Jan Risinger, Masoud Toloue Ph.D.

Most Next Generation Sequencing (NGS) library prep methods introduce sequence bias with the use of enzyme processing and fragmentation steps can introduce errors in the form of incorrect sequence and misrepresented copy number. With molecular indexed libraries, each molecule is tagged with a molecular index randomly chosen from ~10,000 combinations so that any two identical molecules become distinguishable (with odds of 10,000/1), and can be independently evaluated in later data analysis.

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A complete workflow from sample preparation to analysis using SureSelect target enrichment system for Ion Proton semiconductor sequencing
Christian Le Cocq, Kyeong Soo Jeong, Arjun Vadapalli, Joseph Ong, Elin Agne, Filip Karlsson, Ashutosh Ashutosh, Francisco Useche, Jayati Ghosh, Henrik Johansson, Scott Happe, Douglas Roberts, and Holly Hogrefe

Agilent’s SureSelect Target Enrichment for the Ion Proton Platform provides a comprehensive, efficient, robust, and cost-effective means to sequence subsets of the human genome.

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Genotyping-by-Sequencing of a set of diverse spring barley (Hordeum vulgare) accessions
Tina Lüders (1), Jens Keilwagen (2), Neele Wendler (3), Axel Himmelbach (3), Rajiv Sharma (3), Benjamin Kilian (3,4), Nils Stein (3), Frank Ordon (1)

The poster presents a Genotyping-by-Sequencing (GBS) approach to saturate a set of diverse spring barley accessions with a high density of SNP markers.

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Genotyping-by-Sequencing of a set of diverse spring barley (Hordeum vulgare) accessions
Tina Lüders (1), Jens Keilwagen (2), Neele Wendler (3), Axel Himmelbach (3), Rajiv Sharma (3), Benjamin Kilian (3,4), Nils Stein (3), Frank Ordon (1)

The poster presents a Genotyping-by-Sequencing (GBS) approach to saturate a set of diverse spring barley accessions with a high density of SNP markers.

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Stealth-Adapted Viruses and Viteria: Insights into Virus Construction, Replication and Potential Therapies
W. John Martin

There is an increasing incidence of diseases with accompanying signs and symptoms of brain damage. These include neurological and psychiatric illnesses, childhood behavioral disorders, and such common conditions as chronic fatigue, Gulf War Syndrome, so-called “chronic Lyme disease”, and many cancers. Altogether, these diseases have an enormous social impact.

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Showing Results 1 - 10 of 17
Scientific News
Major Study Links Gene to Drug Resistance in Testicular Cancer
Researchers used a genetic technique called whole-exome sequencing to examine tumour samples.
Titin' Gene Mutations Will Help Identify Patients At Risk Of Heart Failure
A new study has identified genetic mutations that cause the heart condition dilated cardiomyopathy (DCM), paving the way for more accurate diagnosis.
Blood Test For Prostate Cancer
Vanderbilt team demonstrates that prostate cancer can accurately be detected by liquid biopsy.
Whole-Genome Sequencing Successfully Identifies Cancer-Related Mutations
UT Southwestern Medical Center cancer researchers have demonstrated that whole-genome sequencing can be used to identify patients’ risk for hereditary cancer.
NHS Genomic Medicine Centres Announced for 100,000 Genomes Project
Eleven centres have been announced across England, to lead the way in delivering the 100,000 Genomes Project.
Promising Compound Rapidly Eliminates Malaria Parasite
An international research collaborative led by St. Jude Children’s Research Hospital reports that the rapid action of (+)-SJ733 will likely slow malaria drug resistance.
Genes that Cause Pancreatic Cancer Identified by New Tool
Screening system in mice spots cancerous changes invisible to sequencing.
Using Genome Sequencing to Track MRSA in Under-resourced Hospitals
Whole genome sequencing of MRSA from a hospital in Asia has demonstrated patterns of transmission in a resource-limited setting, where formal screening procedures are not feasible.
Comprehensive Genomic Study of Sub-Saharan Africans Conducted
New data resource will enhance disease research and genomic diversity studies.
Genetic Errors Linked to More ALS Cases than Scientists had Thought
Number of mutated genes influences the age when the fatal paralyzing disorder first appears.
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