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The Changing Tides of the In Vitro Diagnostics Market
With the increasing focus in personalized medicine, diagnostics plays a crucial role in patient monitoring.
Genetic Overlapping in Multiple Autoimmune Diseases May Suggest Common Therapies
CHOP genomics expert leads analysis of genetic architecture, with eye on repurposing existing drugs.
Surprising Mechanism Behind Antibiotic-Resistant Bacteria Uncovered
Now, scientists at TSRI have discovered that the important human pathogen Staphylococcus aureus, develops resistance to this drug by “switching on” a previously uncharacterized set of genes.
Data Mining DNA For Polycystic Ovary Syndrome Genes
A new Northwestern Medicine genome-wide association study of PCOS – the first of its kind to focus on women of European ancestry – has provided important new insights into the underlying biology of the disorder.
Viral Comparisons
ORNL team applies genomics expertise to analyze, map virus sequence database.
The Tree of Life — More Like A Bush
New species evolve whenever a lineage splits off into several. Because of this, the kinship between species is often described in terms of a ‘tree of life’, where every branch constitutes a species.
Ancient Origins of Deadly Lassa Virus Uncovered
Working as part of an international team in North America and West Africa, a researcher at The Scripps Research Institute (TSRI) has published new findings showing the ancient roots of the deadly Lassa virus, a relative of Ebola virus, and how Lassa virus has changed over time.
Furthering Data Analysis of Next-gen Sequencing to Facilitate Research
Researchers at Cincinnati Children's Hospital Medical Center have developed a user-friendly, integrated platform for analyzing the transcriptomic and epigenomic "big data.
Statistical Technique Helps Researchers Understand Tumor Makeup, Personalize Cancer Treatments
A new statistical method for analyzing next-generation sequencing (NGS) data that helps researchers study the genome of various organisms such as human tumors and could help bring about personalized cancer treatments has been unveiled.
‘Fishing Expedition’ Nets Nearly Tenfold Increase in Number of Sequenced Virus Genomes
Newly developed computational tool finds 12,500 genomes of viruses that infect microbes.
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Next-Generation Data Storage
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Quantum Corp.

The explosion in life sciences data in general, and next-generation sequencing in particular, is nothing short of remarkable. At the 2010 Bio-IT World Expo, the director of IT at a leading genome institute casually remarked that he had just ordered 1.1 petabytes of storage to try to cope with the extraordinary surge in data generation. This puts a premium on sophisticated IT solutions not only for storing data, with reliable and secure backup and retrieval systems. Organizing the data, much of which is generated and viewed once and once only, is a problem that will require more work in future. In this Briefing On supplement, we present a selection of stories published in the past 12-24 months that have examined the technologies that are both creating and solving the next-gen data deluge (“The DNA Data Deluge”).

Increasingly, the value of next-gen sequencing studies is being validated with the identification of rare disease genes in studies of small families (“Next- Generation Genome Sequencing Identifies Disease Genes”). It is possible that the arrival of third-generation sequencing solutions, such as that from Pacific Biosciences (“PacBio’s Eleven”), will reduce the intense need to store image data, but IT managers aren’t popping the champagne corks just yet. One of the most interesting trends in next-gen data management is the potential of “on demand”.

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