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DNA Damage Seen in Patients Undergoing CT Scanning
Along with the burgeoning use of advanced medical imaging tests over the past decade have come rising public health concerns about possible links between low-dose radiation and cancer.
Web App Helps Researchers Explore Cancer Genetics
Brown University computer scientists have developed a new interactive tool to help researchers and clinicians explore the genetic underpinnings of cancer.
New Research Advances Genetic Studies in Wildlife Conservation
‘Next-gen’ DNA sequencing of non-invasively collected hair expands field of conservation genetics.
Gene Testing Now Allows Precision Medicine for Thoracic Aneurysms
Researchers at the Aortic Institute at Yale have tested the genomes of more than 100 patients with thoracic aortic aneurysms, a potentially lethal condition, and provided genetically personalized care.
OGT’s Popular ESHG Workshop Free to View Online
Learn about the next generation of microarrays in one of the best attended workshops of the conference.
Discordant NIPT Test Results May Reflect Presence of Maternal Cancer
Results published in Journal of the American Medical Association.
Sperm RNA Test May Improve Evaluation of Male Infertility
To help resolve uncertainty—and guide prospective parents to the right fertility treatments—scientists propose the use of a new kind of fertility test. It involves examining sperm RNA by means of next-generation sequencing.
How the Mammoth Got its Wool
Evolutionary change in a gene reconstructed in the lab from the woolly mammoth was part of a suite of adaptations that allowed the mammoth to survive in harsh arctic environments, according to new research.
NuGEN Scientists Screen 400+ Genes for Fusion Events in Single Assay
Breakthrough proves efficacy of new sample preparation method that could accelerate cancer research and development of treatments and diagnostic tests.
More Accurate and Comprehensive Whole Genome Assembly
Scientists from the Icahn School of Medicine at Mount Sinai have developed a new approach to build nearly complete genomes by combining high-throughput DNA sequencing with genome mapping.
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Next-Generation Data Storage
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Quantum Corp.

The explosion in life sciences data in general, and next-generation sequencing in particular, is nothing short of remarkable. At the 2010 Bio-IT World Expo, the director of IT at a leading genome institute casually remarked that he had just ordered 1.1 petabytes of storage to try to cope with the extraordinary surge in data generation. This puts a premium on sophisticated IT solutions not only for storing data, with reliable and secure backup and retrieval systems. Organizing the data, much of which is generated and viewed once and once only, is a problem that will require more work in future. In this Briefing On supplement, we present a selection of stories published in the past 12-24 months that have examined the technologies that are both creating and solving the next-gen data deluge (“The DNA Data Deluge”).

Increasingly, the value of next-gen sequencing studies is being validated with the identification of rare disease genes in studies of small families (“Next- Generation Genome Sequencing Identifies Disease Genes”). It is possible that the arrival of third-generation sequencing solutions, such as that from Pacific Biosciences (“PacBio’s Eleven”), will reduce the intense need to store image data, but IT managers aren’t popping the champagne corks just yet. One of the most interesting trends in next-gen data management is the potential of “on demand”.

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