Corporate Banner
Satellite Banner
Next Gen Sequencing
Scientific Community
 
Join | Sign in
Home>Videos>This Video
  Videos

Return

Bacterial Genomic Changes Revealed through Next-generation Sequencing Data Analysis
SELECTBIO

Neisseria gonorrhoeae is capable of causing gonorrhoea and more complex diseases in the human host. The Correia Repeat Enclosed Element (CREE), an IS-like element, has been predicted to be mobile within the neisserial genomes. Although there is evidence of ancestral movement of these elements, no previous study has provided evidence for current mobilisation. The CREE has the ability to alter gene expression and regulation in many ways: by insertional mutagenesis; by introducing promoter elements; and by generating mRNA processing sites. Previous studies have compared the genomic locations of CREE in the Neisseria spp., demonstrating that otherwise identical regions have either the element or the target TA insertion site. We report here movement of CREE, through inversion of the element at its chromosomal location. Analysis of Ion Torrent generated genome sequence data from N. gonorrhoeae strain NCCP11945 revealed a total of 37 CREE inversions that have the capability to alter gene expression in N. gonorrhoeae through the previously determined activities of the sequence features of these elements.

Request more information
Company product page



For access to this article, enter your email address to instantly recieve a Password Reset link.

Please enter your email address below:

Existing users please Sign In here. Don't have an account? Register Here for free access.

Don't have an account? | Register Here

Scientific News
TAU Researchers Solve Disease Mystery Through Crowdfunding
Tel Aviv University researcher identifies novel genetic mutations through DNA sequencing of afflicted child and family.
A Gene That Shaped The Evolution Of Darwin's Finches
Researchers from Princeton University and Uppsala University in Sweden have identified a gene in the Galápagos finches studied by English naturalist Charles Darwin that influences beak shape and that played a role in the birds' evolution from a common ancestor more than 1 million years ago.
DNA ‘Cage’ Could Improve Nanopore Technology
Scientists at Brown University have designed a nanoscale cage that can trap a single DNA strand and allow before-and-after sequencing of the same DNA strand in research trials.
Epigenetic Signatures that Differentiate Triple-Negative Breast Cancers
Australian researchers have identified epigenetic ‘signatures’ that could help clinicians tell the difference between highly aggressive and more benign forms of triple-negative breast cancer.
New Techniques Reveal “Extreme” Gene Copy Range
New findings give scientists the first precise way to study places in the genome where the number of copies of a sequence varies widely from person to person.
New Software Analyzes Human Genomes Faster than Other Available Technologies
The new software will empower population scale genomic analysis.
Major Study Links Gene to Drug Resistance in Testicular Cancer
Researchers used a genetic technique called whole-exome sequencing to examine tumour samples.
Titin' Gene Mutations Will Help Identify Patients At Risk Of Heart Failure
A new study has identified genetic mutations that cause the heart condition dilated cardiomyopathy (DCM), paving the way for more accurate diagnosis.
Blood Test For Prostate Cancer
Vanderbilt team demonstrates that prostate cancer can accurately be detected by liquid biopsy.
Whole-Genome Sequencing Successfully Identifies Cancer-Related Mutations
UT Southwestern Medical Center cancer researchers have demonstrated that whole-genome sequencing can be used to identify patients’ risk for hereditary cancer.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters