Corporate Banner
Satellite Banner
Technology Networks Header
Saturday, December 20, 2014
Technology Networks
 
Register | Sign in
Home Page > Videos > Bacterial Genomic Changes Revealed through Next-generation Sequencing Data Analysis
  Videos

Return

Bacterial Genomic Changes Revealed through Next-generation Sequencing Data Analysis
SELECTBIO

Neisseria gonorrhoeae is capable of causing gonorrhoea and more complex diseases in the human host. The Correia Repeat Enclosed Element (CREE), an IS-like element, has been predicted to be mobile within the neisserial genomes. Although there is evidence of ancestral movement of these elements, no previous study has provided evidence for current mobilisation. The CREE has the ability to alter gene expression and regulation in many ways: by insertional mutagenesis; by introducing promoter elements; and by generating mRNA processing sites. Previous studies have compared the genomic locations of CREE in the Neisseria spp., demonstrating that otherwise identical regions have either the element or the target TA insertion site. We report here movement of CREE, through inversion of the element at its chromosomal location. Analysis of Ion Torrent generated genome sequence data from N. gonorrhoeae strain NCCP11945 revealed a total of 37 CREE inversions that have the capability to alter gene expression in N. gonorrhoeae through the previously determined activities of the sequence features of these elements.

Request more information
Company product page



For access to this article, enter your email address to instantly recieve a Password Reset link.

Please enter your email address below:

Existing users please Sign In here. Don't have an account? Register Here for free access.

Don't have an account? | Register Here

Scientific News
Promising Compound Rapidly Eliminates Malaria Parasite
An international research collaborative led by St. Jude Children’s Research Hospital reports that the rapid action of (+)-SJ733 will likely slow malaria drug resistance.
Genes that Cause Pancreatic Cancer Identified by New Tool
Screening system in mice spots cancerous changes invisible to sequencing.
Using Genome Sequencing to Track MRSA in Under-resourced Hospitals
Whole genome sequencing of MRSA from a hospital in Asia has demonstrated patterns of transmission in a resource-limited setting, where formal screening procedures are not feasible.
Comprehensive Genomic Study of Sub-Saharan Africans Conducted
New data resource will enhance disease research and genomic diversity studies.
Genetic Errors Linked to More ALS Cases than Scientists had Thought
Number of mutated genes influences the age when the fatal paralyzing disorder first appears.
WormBase ParaSite Launched
Open-access database WormBase ParaSite launches with data on 1.5 million genes.
Big Data Set To Make A Big Difference In Childhood Cancer Treatment
UTS researchers are working with the Kids Research Institute to visualise large quantities of patient data to better diagnose and treat childhood cancer patients.
Two Studies Identify A Detectable, Pre-Cancerous State In The Blood
Findings pave way for new lines of cancer research focused on detection and prevention.
Fast, Low-cost DNA Sequencing Technology One Step Closer To Reality
ASU Regents' Professor Stuart Lindsay led a team of scientists from Arizona State University's Biodesign Institute and IBM's T.J. Watson Research Center in the development of a prototype DNA reader that could make whole genome profiling an everyday practice in medicine.
Amazing Feet Of Science: Researchers Sequence The Centipede Genome
What it lacks in genes, it certainly makes up for in legs: the genome of the humble centipede has been found to have around 15,000 genes – around 7,000 fewer than a human.
Scroll Up
Scroll Down
Skyscraper Banner
SELECTBIO Market Reports
LabTube - Videos for the Scientific Community
eposters - The Online Journal of Scientific Posters
Follow TechNetcom1 on Twitter
Technology Networks Ltd. on LinkedIn