|Functional Analysis of RAD51B and RAD23B SNPs using Circular Chromosome Conformation Capture (4C) in Human Prostate Cell Lines|
C. Cieza-Borrella1, S. Wakerell1 , Q. Karlsson1 , R.A. Eeles1,2, Z. Kote-Jarai1
The aim of this study is to understand the mechanism behind the association between single nucleotide polymorphisms (SNPs), lying in non-coding regions near or within RAD51B and RAD23B, and prostate cancer risk by analysing their interactions with the whole genome using Circular Chromosome Conformation Capture (4C).
|Optimization of a Vacuum Ultraviolet Photoionization source for Gas Chromatography used with a High Resolution Time of Flight Mass Spectrometer|
Lloyd Allen and Viatcheslav Artaev
-Tune solution allows optimization of ion source parameters for
both proton transfer and direct ionization
-Independent ionization processes exist for M+ and MH+
-Optimizing for dopant signal intensity yields inferior results
-Degree of fragmentation remains relatively constant over a
range of source conditions
|Preparation of Photonic Biosensors by Inkjet Printing Technology|
F. Strassera, c, E. Melnika, R. Heera, P. Muellnera, G. Mutinatia, R. Hainbergera , J. Kraftb, G. Meinhardtb, J. Siegertb, P. Lieberzeitc
In order to enable local functionalization of label-free optical waveguide biosensors in a cost effective mass-fabrication compatible manner, we investigate surface modification employing inkjet printing of functional polymers and UV-curable benzophenone dextran.
|Building and deploying digital pathology infrastructure for a heterogeneous user base|
Silke Smeets, Stijn Piessens, Sabrina D'Haese, Chris Groven, Wim Waelput, Ramses Forsyth, Peter In't Veld
Too often, image analysis and data/image mining projects remain stuck in
microenvironments because they are limited by vendorspecific
solutions that neither scale nor interact with material from other departments or institutions. Successful rollout of digital histopathology therefore requires more than a whole slide scanner. At Brussels Free
University (VUB), we wanted to provide a core digital pathology infrastructure that can support a range of different use cases.
|Workshop report: Bioinformatics meets digital pathology|
Yves Sucaet, David Ameisen, Zev Leifer, Raphaël Marée, Marius Nap, Jeroen Van der Laak, Paul Van Diest, Yukako Yagi
Pathologists are the guardians of large quantities of high-resolution
imaging material, that is barely noticed by bioinformatics today. Yet this (annotated) material can be of huge contributing value to any research project, as pathology preserves topological tissue features, and can help explain difficult phenomena such as tumor heterogeneity. The goal is then to bridge research methods and materials from the bioinformatics community with the (digital) pathology community.
|A Novel Cell-Free DNA Extraction System for Cancer Diagnostics|
Amanda Fan, Alex Yeo, Yin Kum Ng, Elian Rakhmanaliev, Pramila Ariyaratne, Charlie Lee, Gerd Michel, Tatiana Ivanova
We developed a magnetic bead-based cfDNA extraction kit and integrated it into the automated qPCR- and NGS-based IVD workflows. In this study we are compering this magnetic beads-based cfDNA extraction system with a column-based method.
|Microfluidic extrusion of cell-laden hydrogel fibers for 3D-Bioprinting|
Cristina Colosi, Laura Belloni, Giancarlo Ruocco
An overview on how the incorporation of microfluidic platforms in 3D-bioprinters can open new routes in the creation of heterogeneous, tissue-specific bio-constructs and in the high-throughput screening of bioinks compositions for regenerative medicine and in vitro tissue modeling.
|CRISPR-Cas9 genome editing utilizing chemically synthesized RNA|
Michael Delaney, Kaizhang He, Eldon Chou, Amanda Haas, Žaklina Strezoska, Melissa L. Kelley, and Anja van Brabant Smith Dharmacon, part of GE Healthcare, 2650 Crescent Drive, Lafayette, CO 80026, USA
Chemical synthesis has been easily applied for rapidly generating either crRNA and tracrRNA or synthetic sgRNA for direct delivery into cells for gene editing applications such as DNA-free options and high throughput arrayed screening.
|Analysis of Organic Marker Compounds and Hazardous Organic Compounds by GC/MS to Identify Contamination, Counterfeiting and Adulteration of Spices|
Our previous study of spices was designed to evaluate the metal content in the spices for evidence of contamination by heavy metals or for adulteration and counterfeiting by notable concentrations of wear or additive metals. This study targeted the same spice samples to quantify the characteristic primary and secondary market compounds for each spice group.
|The Chemical Synthesis of Long and Highly Modified RNA using 2'-ACE Chemistry|
Xiaoqin Cheng, Kristina Larson, Letitia Kwok, David Mierzejewski, Shawn Begay, Randy Rauen, Kelly Grimsley, Kaizhang He, Michael Delaney, David Kitchen, Amanda Haas, Melissa Kelley, Anja van Brabant Smith
Dharmacon has previously developed a novel RNA synthesis chemistry making RNA synthesis as reliable, accessible and of comparable quality as routinely observed in DNA synthesis.
|<<|| 1 2 3 4 5 6 7 || >>|
|Showing Results 1 - 10 of 1408||