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Direct Targets Identification of a Bioactive Compound
Sylvain Blanc, Paul Bradley, Marie-Edith Gourdel, Michael Cholay, Gisèle Guimèse, Mike Mckenzie, George Nasi, Jean-Christophe and Barbara Ruggiero

Identifying protein partners of a small bioactive molecule is of great
interest in many aspects of life sciences and specifically in the drug
discovery and development process cycle. It is a support to (i) decipher
the mechanism of action after for example a “High Content” screening,
(ii) study “off-target” effects, (iii) adjust therapeutic indications and
clinical regimens of a drug and (iv) consider drug repositioning.

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3D-Tissue/ Whole-blood Co-culture Models Combined with Multi-Analyte Profile (MAP) Analyses for In-vivo-like Immunopharmacology
Stein GM, Joos T, Schmolz M

Human Organotypic Test (HOT) Systems aim at in-vivo like substance characterisation of all preparations meant to act on the human immune system.

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A multiplexed amplicon sequencing technology for FFPE and circulating, cell-free DNA
Laurie Kurihara, Catherine Couture, Julie Laliberte, Sukhinder Sandhu, Jonathan Irish, Tim Harkins and Vladimir Makarov

A novel amplicon approach allowing for hundreds of amplicons to be multiplexed in a single tube with a two workflow from sample to sequencer.

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An investigation into the effects of aging on automotive bumper samples by xylene soluble flow injection polymer analysis (XS-FIPA)
Bassem Sabagh, Wei Sen Wong, Bernd Tartsch

This poster describes the use of flow injection polymer analysis (FIPA) as an analytical tool for xylene soluble (XS) determination with quick and easy simultaneous measurements of molecular weight (MW), intrinsic viscosity (IV) and XS%. The technique was applied to automotive bumper samples which had undergone an aging test. The results from the XS-FIPA technique highlight the differences caused by the aging process.

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Phenotypic Screening Applied to the Anti-biofilm Drug Discovery: Identification of Anti-biofilm Flavonoids from a Chemical Library
Suvi Manner1*, Malena Skogman2, Pia Vuorela2, Adyary Fallarero2

This work represents a systematic exploration of a flavonoids collection for the inhibitory activity against Staphylococcus aureus biofilms and offers an improved methodological workflow for anti-biofilm screens of chemical libraries taking into account the connections between anti-biofilm and antibacterial properties.

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The role of AHPCO Technology in reducing allergic rhinitis cases as Air Purifier, Surface Sterilizer and Ice Maker sterilizer
Dr. Nabarun K. Ghosh, PhD1, Dr. Constantine K. Saadeh, MD FAAAAI2, Dr. Jeff Bennert, PhD CTN3 and Ms. Griselda Estrada, BS1

Dirty ice makers can cause potential health hazards. To prevent any potential contamination, the interior surfaces of the ice machine must be cleaned and sanitized regularly. This report justifies the demand and use of novel equipment that will sanitize the surface of an ice machine continuously. We evaluated the Bi-Polar® unit built by Air Oasis (1.2) in sanitizing the ice machine surface.

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Marked increase in basophil activation during non-anaphylactic allergic reactions to peanut in man
Paul J. Turner, Orla McMahon, Amy Switzer, Andrew Clark, Robert J. Boyle, Stephen R. Durham and Mohamed H. Shamji

Our data imply an important role for basophils in the evolution of acute IgE-mediated reactions to food allergens.

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Ten-Year Experience with Sublingual Immunotherapy for Juniper Pollenosis
W Donald Cooke MD

Efficacy of sublingual immunotherapy for Juniper induced allergic rhinitis is presented.

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Association between asthma-related emergency department visits, meteorological measurements, and air quality concentrations in the Bronx (2001-2008)
Abraham R(1), Toh J(2), Desai T(2), Shum M(3), Patel P(2), Rosenstreich D(2), Jariwala SP(2)

Evaluate the association between asthma-related emergency department visits (AREDV), meteorological measurements, and air quality concentrations in a high asthma prevalence area, the New York City borough of the Bronx.

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Ocular papillary changes on the caruncle surface in allergic conjunctivitis
Milton M. Hom, OD, FAAO1, Leslie E. O’Dell, OD, FAAO2, Carl J. May, Jr., MD2, Leonard Bielory, MD3

The caruncle is small, pink, globular nodule at the inner corner of the eye. We found the papillary changes of the caruncle corresponds to changes in palpebral conjunctiva seen in allergic conjunctivitis. There may indicate a greater inflammatory response in the caruncle resulting in greater itching in the nasal corners of the eye. Allergists can easily assess the caruncle.

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Showing Results 1 - 10 of 1143
Scientific News
Acoustic Tweezers Device Expands the Range of X-ray Crystallography
A microfluidic device that utilizes ultrasound waves produced by piezoelectric transducers.
UGA Researchers Discover Potential Treatment for Drug-resistant Tuberculosis
Researchers have developed a new small molecule drug as a treatment against multi-drug resistant tuberculosis.
UGA Researchers to Use Crowdsourcing to Track Harmful Algal Blooms
CyanoTRACKER is a ‘Neighborhood watch system for Georgia waters’.
Fighting the Colorado Potato Beetle with RNA
RNA interference protects potato plants against herbivore attack.
A Protein's Novel Role In Several Types Of Cancers Discovered
Stanford ChEM-H scientists are helping to develop a novel cancer therapy based on a new finding of a protein that inadvertently promotes cancer growth.
New Molecule Could Slow The Progression Of Parkinson’s
University of Bath researchers have designed a molecule that, if developed into a drug, could slow the progression of Parkinson's Disease.
Boy or Girl? Lemur Scents Have the Answer
A new study finds that a pregnant lemur’s signature scent depends in part on whether she’s carrying a girl or a boy.
Safer Methods for Stem Cell Culturing
New study from TSRI shows that certain stem cell culture methods are associated with increased DNA mutations.
New Genomics-Driven Surveillance To Track Crop Diseases
New genomics-driven surveillance strategy to tackle emerging and re-emerging crop pathogens that threaten global food security.
Scientists Uncover New Role for Neurotransmitter that Helps Fight Infection
Scientists have shed new light on the complexities of the immune system that could help develop vaccines to boost natural defences against disease.
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