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Microbial Regulation of IgE Production in Early Life
Ana B Blazquez, Jeremiah J Faith, Hugh A Sampson, M Cecilia Berin

Changes in gastrointestinal microbiota have been suggested to drive the increasing prevalence of food allergy. Our aim was to determine the impact of mouse and human intestinal microbiota on modulation of allergic parameters including IgE.

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Tolerance to Allergenic Foods Following Food Oral Immunotherapy (FOIT)
AR Hague1, RL Wasserman1,2, SK Silvers1,2, RW Sugerman1,2, M Herbert3

We report on 21 patients who completed FOIT (food oral immunotherapy) escalation followed by a period of maintenance dosing and later underwent a tolerance FC (food challenge). 90% of tested FOIT patients and 94% of patients who met our pre-defined criteria for tolerance FC achieved tolerance to their allergenic food.

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Single Practice Six-Year Experience Treating Food Allergy With Oral Immunotherapy
DM Pence1, AR Hague1, RL Wasserman1,2, SK Silvers1,2, RW Sugerman1,2, M Herbert3

We report a more-than-six-year experience with food oral immunotherapy (FOIT) in a private allergy practice setting. Most patients can be desensitized to one or more allergenic foods. Ongoing evaluation and modification of the FOIT procedures improves outcomes and acceptability. FOIT can be successfully performed in an allergy office.

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Peanut Allergy: An epidemiologic analysis of a large database
Leickly, FE, Vitapur, G, and Kloepfer, K

Over three years, 700 children with a peanut story - either peanut sensitization or peanut allergy- were asked to participate in a database.

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EU-OPENSCREEN - The European Research Infrastructure of Open Screening Platforms for Chemical Biology
Bahne Stechmann

EU-OPENSCREEN (www.eu-openscreen.eu) is the largest emerging academic chemical biology research infrastructure initiative in Europe with the aim to collaboratively develop novel research tool compounds with external scientists. As a joint effort of national networks in 16 European countries, EU-OPENSCREEN offers access to high-throughput screening platforms, chemistry services, an open-access database, a large compound collection and an open-access database.

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Measuring the 2nd Virial Coeffient and Molecular Density of Proteins to Improve Crystallization
Michel Terray, John Stenson

The second virial coefficient of Human Serum Albumin (HSA) was measured using a SEC-MALS 20 detector connected to a Refractive Index concentration detector and an online differential viscometer. Two different buffer conditions, Phosphate buffer pH 7.4 and Citrate buffer pH 4.1 were used, which revealed interesting and contrasting data

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Reducing Biases in Small RNA Sequencing
Adam Morris Ph.D., Dawn Obermoeller, Masoud Toloue Ph.D.

Small RNA-Seq libraries utilizing randomized adapters demonstrated significantly less bias and more even coverage due to reductions in ligase bias.

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Amplicon Based 16S Ribosomal RNA Sequencing and Genus Identification
*Jan Risinger, *Lindsey Renken, +Josh Hill, +Noushin Ghaffari, PhD, +Richard P. Metz, PhD, +Charles D. Johnson, PhD, *Masoud M. Toloue, Ph

Rapid determination of highly complex bacterial populations through targeted amplification of 16S rRNA V1 - V3 hypervariable regions can provide an accurate gauge of diversity at taxonomic hierarchies as low as the genus level.

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Fighting Blindness with 3D-NET "Drug Discovery & Development of Novel Eye Therapeutics"
Pilar Ventosa-Andrés, Nils Ohnesorge, Yolanda Fernández, Yolanda Alvarez and Breandán Kennedy

3D-NET, “Drug Discovery & Development of Novel Eye Therapeutics”, is a new European research consortium of industry and academic partners focusing efforts to enhance the discovery and development of drugs targeting ocular pathologies that lead to blindness.

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Scientific News
Study Finds Brain Chemicals that Keep Wakefulness in Check
Researchers to develop new drugs that promote better sleep, or control hyperactivity in people with mania.
Sorting Through Cellular Statistics
Aaron Dinner, professor in chemistry, and his graduate student Herman Gudjonson are trying to read the manual of life, DNA, as part of the Dinner group’s research into bioinformatics—the application of statistics to biological research.
Playing 'Tag' with Pollution lets Scientists See Who's It
Using a climate model that can tag sources of soot from different global regions and can track where it lands on the Tibetan Plateau, researchers have determined which areas around the plateau contribute the most soot — and where.
Women’s Immune System Genes Operate Differently from Men’s
A new technology reveals that immune system genes switch on and off differently in women and men, and the source of that variation is not primarily in the DNA.
Long Telomeres Associated with Increased Lung Cancer Risk
Genetic predisposition for long telomeres predicts increased lung adenocarcinoma risk.
First Artificial Ribosome Designed
Researchers at the University of Illinois at Chicago and Northwestern University have engineered a tethered ribosome that works nearly as well as the authentic cellular component, or organelle, that produces all the proteins and enzymes within the cell.
High-Resolution 3D Images Reveal the Muscle Mitochondrial Power Grid
NIH mouse study overturns scientific ideas on energy distribution in muscle.
Expanding the Brain
A team of researchers has identified more than 40 new “imprinted” genes, in which either the maternal or paternal copy of a gene is expressed while the other is silenced.
Identifying a Key Growth Factor in Cell Proliferation
Researchers discover that aspartate is a limiter of cell proliferation.
Study Uncovers Target for Preventing Huntington’s Disease
Scientists from Cardiff University believe that a treatment to prevent or delay the symptoms of Huntington’s disease could now be much closer, following a major breakthrough.
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