Idebenone Inhibits Cell Proliferation by Blocking of ANO1/ TMEM16A Chloride Channel in Adenocarcinoma Cells Yohan Seo
Idebenone significantly reduced cell proliferation and induced apoptosis in PC-3, CFPAC-1, HT-29, T-84 and Calu-3 cells having CaCCs activities. These data suggest that idebenone, an ANO1/CaCC inhibitor, has potential for use in cancer therapy.
Pressure-Based Volume Measurement Technology for In-process Measurement of Microplate Contents John Thomas Bradshaw, Bill Gigante, Christoph Schwedes
Modern drug discovery and research labs are utilizing complex automation systems to assist in high throughput screening of novel drug candidates. A large portion of these laboratories are using ANSI-SBS-standard 96- and 384-well plates to achieve the necessary throughput. The volume of sample transferred into and out of these plates can be critical to the success of assays or validation of procedures.
Environmental Studies Using the Tecan QC Kit and an Automated Liquid Handling System George Rodrigues, Emily Avis, Alf Price, Verena Gerber
The study illustrates the effect of two environmental factors (air temperature and humidity) on the volumetric performance of a Tecan Freedom EVO ® pipetting robot, equipped with a liquid LiHa (Liquid Handling Arm). Tecan recommends that the EVO be installed in a controlled environment. However, some users choose to operate in less controlled conditions.
Stable Chloroplast: Myth or Reality? Shailesh Joshi and Dyfed Evans
Chloroplasts principally encode the photosynthetic machinery in Viridiplantae. It has long been accepted that in photosynthetic plants chloroplast genomic structure is uniquely stable as it is maternally and clonally inherited. The first chloroplast genomes sequenced supported this view. The current study was undertaken to address the potential issue of global chloroplast(in)stability.
Validation of Collection and Extraction Methods of Saliva for Use in Biomarker Research Sarah E. Hurst and Brandon T. Hall
This poster investigates the collection and extraction methods of saliva for use in biomarker research.
Rapid Detection of Somatic Mutations in Cancer Genes Michael J. Powell et. al.,
Rapid higly sensitive detection of tumor gene mutations in DNA derived from FFPE or plasma samples can be achieved with QClamp PCR technology.
Accurate Normalization of Grain Samples Using Pressure-Based Volume Measurement Technology Bill Gigante, John Thomas Bradshaw, Tanya Knaide
A common challenge experienced by sample screening facilities is identifying individual sample quantity prior to DNA extraction. Accurately identifying sample quantity allows the user to pipette exact amounts of extraction buffer into each well.
Specificity of highly potent miRNA inhibitors Barbara Roberston, Andrew Dalby, Yuriy Fedorov, Jon Karpilow, Anastasia Khvorova, Devin Leake, Annaleen Vermeulen
Specificity of highly potent miRNA inhibitors
Development of a Microfluidic Device for Sperm Movement Shweta Bhagwat (b), Vibha Jayaraj* (b), Priyanka Parte (a), Sameer Jadhav (b)
We show the design of a device for studying sperm chemotaxis and the testing of different chemicals as a source of chemoattractants.