Posters

In this study, we used high temperature molecular dynamics simulation (400 K), because it is known that critical fluctuations of lipid membranes can even occur at 313 K and especially above 343 K the interlamellar water layer thickness starts to increase non-linearly due to "hydration force". We implemented this method to emphasize POPC and POPE (palmitoyl-oleoyl-phosphatidylethanolamine) membrane bilayer stability enhanced with single-wall carbon nanotube.

The estrogen receptors (ER) refer to a group of the nuclear hormone receptor superfamily of ligand-mediated transcriptional factors. Over expression of this type of receptors leads to a breast cancer progression. Hormone-responsive breast cancer develops resistance to conventional anti-cancer therapy, and this becomes a major problem in a breast cancer therapy.

Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations of the CF transmembrane conductance regulator protein (CFTR), a cAMP-regulated chloride channel. One of the most common CFTR mutations is the deletion of phenylalanine in 508 position (DelF508-CFTR). This mutation induces small conformational change hence the CFTR trafficking is no more effective. The main idea is to find a molecule to facilitate the DelF508-CFTR trafficking to the plasma membrane.

In Arabidopsis, SEU and SLK2 are redundant components of a regulatory complex that is proposed to promote shoot apical meristem (SAM) formation during embryogenesis. Expression analysis indicates that SEU and SLK2 act upstream of several known SAM regulators, and also regulate auxin accumulation, probably via interaction with auxin response factors.

Routine surveillance programs to detect microbial agents in non-human primate colonies are critical to maintaining colony health and safety, as well as research integrity. Serological testing is a crucial element of maintaining colony health, but current methods rely on slow, expensive, and low-throughput ELISA-based serological assays. Here we describe the development of a sensitive, specific, robust, and easily automated method for colony health screening programs.

Quality by Design (QbD) has been widely applied to pharmaceutical manufacturing to enhance process robustness, and improve product quality and manufacturing productivity. Recently, there arose tremendous interests from both the pharmaceutical industry and regulatory agents to expand it to analytical methodology.

White clover is an important forage legume in temperate pastures, but does not have sufficient resistance against drought stress. Quercetin is a flavonol conferring plant sunscreen and anti-oxidant properties under UV-B stress with a trade-off of reduced biomass. An F1 full-sib cross between stress tolerant and stress sensitive white clover genotypes showed the ability to increase Q accumulation associated to maintenance of dry matter yield under a near wilting drought.

Suggestions are provided of how efficient industrial bioprocessing can be accomplished, independently of highly expensive molecular biology approaches, in order to recover natural products of medicinal value from wild plant species.

To detect small molecules in biological extracts, LC/MS performed using high resolution time of flight with accurate mass analysis is a powerful technology. Together with advanced data processing algorithms, accurate mass and relative isotope abundance measurements, molecular formulae can be determined and compounds identified.