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Molecular Dynamics Simulation Study of Pulmonary Surfactant Interacting With Nanoparticles

MD simulation studies using NAMD of lipid bilayers supported on alpha-quartz (nanoparticles) and kaolinite with explicit water molecules will be presented to understand the physiochemical effects of nanoparticles on pulmonary surfactant.

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Pharmacokinetic Delivery and Metabolizing Rate of Nicardipine Incorporated in Hydrophilic and Hydrophobic Cyclodextrins using Two-Compartment Model

The dispersion routes of cyclodextrin complexes with nicardipine (NC), such as hydrophilic hydroxypropyl-ß-cyclodextrin (NC/HPßCD) and hydrophobic triacetyl-ß-cyclodextrin (NC/TAßCD), through the body for controlled drug delivery and sustained release have been examined.

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Cloning And Purification of a Putative Repressor Protein from Arthrobacter nicotinovorans Pao1

The soil bacterium Arthrobacter nicotinovorans carries the pAO1 catabolic megaplasmid which enables it to grow on nicotine (Igloi and Brandsch, 2003).

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Recycled Gas Flow Control to Optimize Reaction Conversion and the Accomplishment of Heat Integration in Benzene Production through Hydrodealkylation of Toluene

In this work, a benzene production plant through hydrodealkylation process was investigated through a simulation by Aspen Plus V7.2® and run based on the real data obtained from a benzene production plant operating in the United States.

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Rapid Concentration of Particles in Microfluidics using AC Electrothermal Effect with Laser Illumination

In this study, the formation of a toroidal microvortex by AC electrothermal (ACET) effect was numerically visualized using COMSOL v4.2a multiphysics software. AC voltage was applied to the two parallel electrodes in a microchannel to generate temperature gradient in the fluids.

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A Novel Synthetic Peptide as a Tool for Microvesicles / Exosomes isolation ©

We have engineered and validated a synthetic peptide (Vn96*) with specific affinity for canonical heat shock proteins (HSPs) as a tool for rapid isolation of Exosomes or extracellular microvesicles (together referred to as eMVs here) from cell culture media, human and animal body-fluids.

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Determination of Metabolically Unstable Drugs in Blood by Heat-Stabilized DBS and LC-MS/MS

The aims of this work were to investigate drug stability prior to, during and after blood spot sampling, using procaine, prulofloxacine, esmolol, and acetylsalisylic acid as examples of drug compounds with limited stability and to compare conventional DBS sampling procedure with DBS sampling including heat stabilization.

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Hypothesis of an Existence of a Reverse Pathway (Rp) which Passes Genetic Information from Polypeptide Antigens to Ig Genes in B-Lymphocytes
Victor J. Alexander

Results of this research will bring new more effective treatment methods of many immune related diseases, including cancer.

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Microfluidic analysis of amino acids using aminoacyl-tRNA synthetase coupled with spectrophotometric detection

Analyses of free amino acids in biological fluids?—?such as urine and plasma?—?can be useful in determining disease status in clinical diagnoses [1]. In the food industry, unique changes in amino acid concentrations are useful markers of freshness, nutrition, and taste.

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Scientific News
Eppendorf Award for Young European Investigators 2015: Call for Entries!
Eppendorf Award celebrates 20 years in 2015.
BPA Exposure by Infants May Increase Risk of Food Intolerance
Exposure to Bisphenol A at a dose significantly below the current FDA Tolerable Daily Intake predisposes offspring to food intolerance at adulthood.
Scientists Generate First Human Stomach Tissue in Lab with Stem Cells
Unprecedented tool for researching the development and diseases of an organ central to several public health crises.
Accelerating Spirocyclic Polyketide Synthesis
Powerful flow chemistry techniques used for complex multi-stage synthesis of spirocyclic polyketides.
MS Drug Candidate Shows Promise for Ulcerative Colitis
Positive new clinical data were released today on a drug candidate for ulcerative colitis that was first discovered and synthesized at The Scripps Research Institute.
First Atlas of Body Clock Gene Expression in Mammals Informs Timing of Drug Delivery
Penn Medicine study has implications for 100 top-selling US drugs, half of which target daily-oscillating genes.
New Technique has Profound Implications for Drug Development
The method, developed by Scripps Research Institute chemists, expands options for making pure batches of ‘one-handed’ molecules.
Blood Test Developed to Diagnose Early Onset Alzheimer’s Disease
New blood-test could predict a person’s risk of developing AD much earlier than is currently possible.
Tea and Citrus Products Could Lower Ovarian Cancer Risk
New UEA research finds that women who consume foods containing flavonols and flavanones significantly decrease their risk of developing epithelial ovarian cancer.
TxCell Achieves Positive Results for Col-Treg in a Model of Autoimmune Uveitis
TxCell set for phase I/II proof of principle clinical study in Q2 2015 for its second therapeutic candidate in this rare eye disease.
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