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Finite element modelling for the optimization of temperature control in Lab-on-a-Chip devices
T. Pardy(a,b); T. Rang(a); I. Tulp(b)

The presented finite element model aims to help in the development of Lab-on-a-Chip devices which require temperature control. The model simulates the thermal system in such devices to enable in silico validation of designs and geometry optimization, and aims to be a versatile tool supporting multiple temperature control methods.

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Development of an Integrated Paper-based Molecular Diagnostic Platform
Manoharanehru Branavan, Wamadeva Balachandran

The poster describes a modular development of a paper-based molecular diagnostic device and the latest results obtained from a proof-of-concept device.

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Advanced Microfluidic Mixing Device for the Study of Macromolecule Dynamics
Shubha Jain, F. Azam, Dr. H. N. Unni

We have developed and characterized a micro-fluidic mixer to study the macro-molecule dynamics such as kinetics of protein folding, DNA sequencing, single molecule study and detection etc. on a micro-second timescale. Numerical simulation has been performed to analyse the study of mixing performance of micro-fluidics channel.

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A combined cell placement and migration assay device for cancer cell anti-migration drug screening
Colin L. Hisey1,2, Oihane Mitxelena-Iribarren2,3, Miguel Martinez-Calderon2, Sergio Arana2,3, Maite Mujika2,3, S.M. Olaizola2, Derek J. Hansford1

We have developed a microfluidic device capable of hydrodynamically trapping cells over polymer lines which encourage 1D migration based on topographical cues. These lines have been fabricated with both femtosecond laser ablation and dewetting/stamping. This type of precise control will allow precise microfluidic assessment of potential drug targets to limit cancer cell migration.

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Analysis of Terpenes Using Gas Chromatography with Vacuum Ultraviolet
Changling Qiu, Jonathan Smuts, Phillip Walsh, and Kevin A. Schug

The VUV absorption spectra for different terpenes were distinctive and differentiable. GC-VUV demonstrated the capabilities for qualitative and quantitative analysis of terpenes in turpertine mixtures. Chromatographic coeluting signals can be deconvolved by the VUV data analysis software.

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Mobility of Aeroallergens in Home: Effect of Location of Air Sampling and Implication for Evaluation of Patient Exposure
Julian Gordon1, Paul Detjen, Andrea Wachter & Prasanthi Gandhi1

The Inspirotec sampler permitted the easy testing of multiple locations within a household. Air sampling simultaneously at 12 locations by other technologies would have been technically challenging. These were run by an untrained operator.

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Lutjanus jocu (Dog snapper) as a bio-indicator of emerging contaminants and changes in environmental condition.
M. Sánchez-García1, S. J. Zottoli2 & L.Roberson-Murillo1

Our research assesses the use of Lutjanus jocu as a bioindicator of changes in environmental condition and water contaminated with toxic substances in estuarine ecosystems.

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Selective Debenzylation of N-Benzyloxypyrazinones in Flow
Anh Hung MAI - Cedrick VERYSER - Wim DE BORGGRAEVE

Selective and reproducible debenzylation of benzyloxypyrazinones by using catalytic transfer hydrogenation in flow chemistry to yield N-hydroxypyrazinones. The flow methodology enabled us to avoid overreduction of the compounds to pyrazin-2(1H)-ones.

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Differences in the Neurophysiology of Infants with Down Syndrome May Predict Protective/Risk Markers for Subsequent Alzheimer’s Disease
Esha Massand1,2, Hana D’Souza1,2, George Ball1,2, Maria Eriksson1, Charlotte Dennison1, Joanna Ball1 & Annette Karmiloff-Smith1,2

Our work set out to understand early individual differences in memory abilities of infants with DS that may be predictive of subsequent cognitive phenotypes of AD.

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Showing Results 11 - 20 of 1360
Scientific News
Releasing Cancer Cells for Better Analysis
A new device developed at the University of Michigan could provide a non-invasive way to monitor the progress of an advanced cancer treatment.
Releasing Cancer Cells for Better Analysis
A new device developed at the University of Michigan could provide a non-invasive way to monitor the progress of an advanced cancer treatment.
Apricot Kernels Pose Risk of Cyanide Poisoning
Eating more than three small raw apricot kernels, or less than half of one large kernel, in a serving can exceed safe levels. Toddlers consuming even one small apricot kernel risk being over the safe level.
Cell Transplant Treats Parkinson’s in Mice
A University of Wisconsin—Madison neuroscientist has inserted a genetic switch into nerve cells so a patient can alter their activity by taking designer drugs that would not affect any other cell.
Understanding Female HIV Transmission
Glowing virus maps points of entry through entire female reproductive tract for first time.
Genetic Markers Influence Addiction
Differences in vulnerability to cocaine addiction and relapse linked to both inherited traits and epigenetics, U-M researchers find.
Lab-on-a-Chip for Detecting Glucose
By integrating microfluidic chips with fiber optic biosensors, researchers in China are creating ultrasensitive lab-on-a-chip devices to detect glucose levels.
A lncRNA Regulates Repair of DNA Breaks in Breast Cancer Cells
Findings give "new insight" into biology of tough-to-treat breast cancer.
COPD Linked to Increased Bacterial Invasion
Persistent inflammation in COPD may result from a defect in the immune system that allows airway bacteria to invade deeper into the lung.
Detection of HPV in First-Void Urine
Similar sensitivity of HPV test on first void urine sample compared to cervical smear.
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