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Early Immunogenicity Risk Mitigation
Chloé Ackaert, Brecht Hoedemaekers, Sofie Pattijn and Philippe Stas

The ability of a drug candidate to induce an unwanted immune response can be a significant hurdle during drug development and a reason for product failures. Unwanted immunogenicity can cause loss of efficacy, altered pharmacodynamics and stability problems. .

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Mimetix® Electrospun Scaffolds for 3D Culture of Upcyte® and Primary Hepatocytes
E. Heister, R. McKean (1) S. D. Ramachandran, B. Munst (2) B. Burkhardt, V. Haussling, A. Niissler (3)

This study investigates the Mimetix® electrospun scaffold, which consists of highly uniform electrospun PLLA microfibres supporting the three-dimensional growth of cells, as a cell-based assay system for upcyte® and primary hepatocytes.

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Novel Gpr39 Agonists: Correlation Of Binding Affinity Using Label-Free Back-Scattering Interferometry With Potency In Functional Assays
Daniel Brown (1), Niklas Larsson (2), Ola Fjellström (3), Anders Johansson (3), Sara Lundqvist (2), Johan Brengdahl (2), and Richard J. Isaacs (1)

We describe the application of back-scattering interferometry (BSI) to the characterization of small molecule ligand binding to human GPR39 (a GPCR targeted for type-2 diabetes therapy) overexpressed in crude membrane fractions in free solution, including how BSI-derived affinity and functional assay-derived potency correlate for compounds of varying scaffolds.

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Searching for Urinary Biomarkers of Exposure to Heterocyclic Amines (HCAs)
Rosa Busquets, Henrik L. Frandsen, Kerstin Skog

Heterocyclic amines (HCAs) are foodborne carcinogens present in cooked meat and fish, mainly. Metabolites of HCAs have been determined in urine from volunteers following a controlled meal.

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Rapid Quantification of Proteins in Complex Matrices using the DeNovix DS11 Microvolume Spectrophotometer
Mebs A Surve & Dan Schieffer

In this poster, we will introduce the DeNovix DS-11 as the next generation in microvolume spectrophotometry.

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Mixtures Analysis of Complex Mixtures
Michael Bernstein; Carlos Cobas; Santi Domínguez; Manuel Pérez; Agustín Barba

We describe an NMR method to quantify mixture components in wine, edible oils, etc. The method is fully customizable, and amenable to high throughput operation.

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A Complete Wine Analysis Using Multiplets Detection
Dr Michael Bernstein1; Agustín Barba1; Dr Susanne Klein2; Dr Andrea Dreiseitel2; Daniel Heidger2 and Volker Heidger2

NMR mixtures analysis can be used to determine the concentration of key components in wine. Here we show the analysis using SMA from Mestrelab.

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DPPH scavenging activities of selected flavonoids and their mixtures
Brachos D.(1)

The aim is to identify the ati-oxidant activity of selected flavonoids (quercetin, luteolin and galangin) and their mixtures using DPPH method including their synergistic or antagonistic interactions.

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Effects of aquaculture effluents on nitrogen characteristics in two Chinese estuaries
David Kaiser, Lucia S. Herbeck

The poster describes similarities and differences of the effects aquaculture effluents have on the nitrogen composition in estuarine waters of two sites in southern China

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Showing Results 31 - 40 of 1052
Scientific News
Magnesium Cuts Diabetes Risk
Only about half of Americans get the recommended daily amount in their diet.
Major Step Forward in Understanding of Viruses
Scientists unlock exact structure of Hepatitis A virus.
TGAC Leads Research To Help Identify Animal-To-Human Transmitted Diseases
The Genome Analysis Centre (TGAC) will lead research into the development of bioinformatics to support the identification and characterisation of viruses through metagenomics.
Lab-developed Intestinal Organoids form Mature Human Tissue in Mice
Study produces unprecedented model to study intestinal diseases.
Study Investigates Inherent Contamination in Deep Well Microplates
Study gives data on microplates from numerous manufacturers based in Europe, USA and China.
Revalesio’s Drug Shows Promise in Treating Alzheimer’s
Multiple published research studies outline the potential for RNS60 to effectively treat Alzheimer’s disease by protecting neuronal function and restoring neuronal plasticity.
Shaking Up Cell Biology
Researchers focus in on decades old mystery.
Drinking Water Odors, Chemicals Above Health Standards Caused by 'Green Building' Plumbing
Several types of plastic pipes in eco-friendly green buildings in the United States have been found to leach chemicals into drinking water that can cause odors and sometimes exist at levels that may exceed health standards.
Fruit Fly Could Help Sniff Out Drugs and Bombs
Research from the University of Sussex has found a fly’s sense of smell could be used in new technology to detect drugs and bombs.
Nanoparticles Give up Forensic Secrets
Researchers from Switzerland have thrown light on the precise mechanisms responsible for the impressive ability of nanoparticles to detect fingermarks left at crime scenes.
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