|HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR DETERMINATION OF LIPOIC ACID IN THE FORM OF 2-S-PYRIDINIUM DERIVATIVE|
Chwatko G. (1), Krawczyk M. J. (1), Iciek M. (2), Bilska-Wilkosz A. (2), Marcykiewicz B. (3), Glowacki R. (1)
* The method can be used for routine clinical monitoring of LA in human plasma and urine.
* The method was validated for urine and plasma samples.
* The imprecision, expressed as relative standard deviation value, were within range 0.8-7.7% and 0.9-6.2% for plasma and urine samples, respectively.
* The analytical recovery were from 97.3 to 117.0% for plasma and from 96.5% to 111.5% for urine samples.
|APPLICATION OF LIQUID CHROMATOGRAPHY WITH UV DETECTION FOR DETERMINATION OF PLANT GROWTH REGULATOR IN COMMON PLANT FERTILIZERS|
Borowczyk K., Wyszczelska-Rokiel M., Stachniuk J., Chwatko G., Glowacki R.
1. The methodology allows facile and accurate determination of IBA in common plant fertilizer samples.
2. The analytical figures of linearity, precision and recovery shown during the method validation procedure are well within the criteria for biological sample analysis.
3. In temperature -18, 4 and 25 °C the analyte stays stable for 6 h.
4. The assay should help in control of phytohormones concentration in plants and fertilizers.
|INTERACTION BETWEEN WHEY PROTEIN NANOPARTICLES AND FATTY ACIDS |
Hassan, Z.M.R*, Awad R. A.*, El-Sayed, M. M. **, Mevat I. Foda**, Otzen, D.*** and Heba H. Salama**
Nanocomplexes can be formed from WPI with good cytotoxic effect to tumer cells using cis-vaccenic and linolenic fatty acids comparable to oleic acid. It was a new interesting observation being that the nanocomplexes formed of WPI with fatty acids has a comparable cytotoxcisty to that of a-LA and ß-lg and can be used in tumor therapy.
|A Rapid and Effective Tool for Monitoring Monoclonal Antibody Production|
B. Bhullar, Ph.D., Carlina Hui, B.Sc., M. Hariharan, M.Sc., J. Hewitt, B.Sc , and N. Vats, Ph.D.
Monoclonal antibodies (Mab) are used in a variety of fields from diagnostics to therapeutics. Manufacturers of in vitro diagnostics (IVD) commonly use third-party suppliers to meet their needs for specified monoclonal antibodies.
|A Novel Approach Toward Microfluidic Drug Metabolite Synthesis – Electrosynthetic Methodology Simulating Cytochrome (CYP450) Oxidation|
Romain Stalder, Gregory P. Roth and Philip Podmore
A novel microfluidic technology and electrochemical synthesis method is demonstrated for the efficient generation of known drug metabolites. These metabolites are typically generated on first pass hepatic oxidation in vivo. The FLUX Module, a new microfluidic electrochemical cell manufactured by Syrris Ltd., has been employed to generate the metabolites of five commercial drugs: Tolbutamide, Chlorpromazine, Diclofenac, Primidone and Albendazole.
|MS Data Processing With Full Flexibility Of Universal Processing Software|
Frans Schoutsen, Barbara van Cann, Vincent Jespers, Michal Godula
Liquid Chromatography (LC) in combination with triple quadrupole Mass Spectrometry (MS) is more and more a common analysis technique in routine laboratories. Especially when using MS/MS selected reaction monitoring (SRM) for a large number of components data handling can be a bottle neck. This poster will show MS data processing of pesticides in water samples using an already established chromatography data system which is now also capable of processing large quantities of MS data.
|Analysis of Dithiocarbamate Pesticides by GC-MS|
Soma Dasgupta1,2, Sumaiyya Mujawar1, Kaushik Banerjee1, Hans-Joachim Huebschmann3, Paul Silcock4
Analysis of dithiocarbamate pesticides (DTCs) using an optimized GC-MS method is described. DTCs are not stable and cannot be extracted or analyzed directly. The purpose of this work was develop a reliable method for identification and quantification of residues.
|Analysis of Multiresidue Pesticides Present in Ayurvedic Churna by GC-MS/MS|
Manoj Surwade, Sunil T Kumar, Aarti Karkhanis, Manish Kumar, Soma Dasgupta, Hans-Joachim Huebschmann, Paul Silcock, Thermo Fisher Scientific
Analysis of Herbal powders or ‘churnas’ using an optimized GC-MS/MS method is described. As they have high amount of matrix co-extractives, they pose critical analytical problems. The purpose of this work was overcome the effect of the matrix and develop a reliable method.
|Automated Solid-Phase Extraction of Oraganochlorine Pesticides from Drinking Water|
Frans Schoustsen and Pranathi R Perati
A new method was developed to automate the capture and elution of Organochlorine pesticides from drinking water. The concentrated analytes were then analyzed by GC with Electron Capture Detection (ECD).
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