|Advanced Microfluidic Mixing Device for the Study of Macromolecule Dynamics|
Shubha Jain, F. Azam, Dr. H. N. Unni
We have developed and characterized a micro-fluidic mixer to study the macro-molecule dynamics such as kinetics of protein folding, DNA sequencing, single molecule study and detection etc. on a micro-second timescale. Numerical simulation has been performed to analyse the study of mixing performance of micro-fluidics channel.
|A combined cell placement and migration assay device for cancer cell anti-migration drug screening|
Colin L. Hisey1,2, Oihane Mitxelena-Iribarren2,3, Miguel Martinez-Calderon2, Sergio Arana2,3, Maite Mujika2,3, S.M. Olaizola2, Derek J. Hansford1
We have developed a microfluidic device capable of hydrodynamically trapping cells over polymer lines which encourage 1D migration based on topographical cues. These lines have been fabricated with both femtosecond laser ablation and dewetting/stamping. This type of precise control will allow precise microfluidic assessment of potential drug targets to limit cancer cell migration.
|DNA-free CRISPR-Cas9 genome engineering in zebrafish|
Amanda Haas, Alex J. Blasky*, Rytis Prekeris*, John A. Schiel, Melissa L. Kelley, and Anja van Brabant Smith | Dharmacon, now part of GE Healthcare, 2650 Crescent Drive, Suite 100, Lafayette, CO 80026, USA *University of Colorado - Anschutz Medical Campus, Department of Cell & Developmental Biology, Denver, CO, USA
Poster describing the advantages of a DNA-free gene editing system and the application of this system in zebrafish.
|Analysis of Terpenes Using Gas Chromatography with Vacuum Ultraviolet |
Changling Qiu, Jonathan Smuts, Phillip Walsh, and Kevin A. Schug
The VUV absorption spectra for different terpenes were distinctive and differentiable. GC-VUV demonstrated the capabilities for qualitative and quantitative analysis of terpenes in turpertine mixtures. Chromatographic coeluting signals can be deconvolved by the VUV data analysis software.
|Mobility of Aeroallergens in Home: Effect of Location of Air Sampling and Implication for Evaluation of Patient Exposure|
Julian Gordon1, Paul Detjen, Andrea Wachter & Prasanthi Gandhi1
The Inspirotec sampler permitted the easy testing of multiple locations within a household. Air sampling simultaneously at 12 locations by other technologies would have been technically challenging. These were run by an untrained operator.
|Lutjanus jocu (Dog snapper) as a bio-indicator of emerging contaminants and changes in environmental condition.|
M. Sánchez-García1, S. J. Zottoli2 & L.Roberson-Murillo1
Our research assesses the use of Lutjanus jocu as a bioindicator of changes in environmental condition and water contaminated with toxic substances in estuarine ecosystems.
|Selective Debenzylation of N-Benzyloxypyrazinones in Flow|
Anh Hung MAI - Cedrick VERYSER - Wim DE BORGGRAEVE
Selective and reproducible debenzylation of benzyloxypyrazinones by using catalytic transfer hydrogenation in flow chemistry to yield N-hydroxypyrazinones. The flow methodology enabled us to avoid overreduction of the compounds to pyrazin-2(1H)-ones.
|600 base reads on the Ion S5™ Next-Generation Sequencing System enables accurate HLA typing of 96 samples on one 530™ chip|
Peter B. Vander Horn, Cisilya Duncan, Jamsheed Ghadiri, Amneet Gulati, Diana Jeon, April Jung, Mindy Landes, Tommie Lincecum, Geoffrey Lowman, Vadim Mozhayskiy, Linus Ong, Xinzhan Peng, Maryam Shenasa, Prasanna Thwar
We have demonstrated that by combining improvements in templating and sequencing biochemistry we are able to sequence templates longer than 600 bases with high accuracy on an Ion S5 530 chip.
These improvements open the S5 use space to include haplotyping applications that require longer reads. As a demonstration of that, we accurately typed 96 HLA samples on one 530 chip.
|Differences in the Neurophysiology of Infants with Down Syndrome May Predict Protective/Risk Markers for Subsequent Alzheimer’s Disease|
Esha Massand1,2, Hana D’Souza1,2, George Ball1,2, Maria Eriksson1, Charlotte Dennison1, Joanna Ball1 & Annette Karmiloff-Smith1,2
Our work set out to understand early individual differences in memory abilities of infants with DS that may be predictive of subsequent cognitive phenotypes of AD.
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