|Correlation between plasma levels of lutein and oxidized low density lipoproteins: a short human intervention study|
Tiziana Bacchetti, Gianna Ferretti
The increase of plasma carotenoids, in particular lutein, after dietary treatment for two weeks is associated with a significant protective effect against lipid peroxidation of plasma lipoproteins.
|Analysis of 10 systemic pesticide residues in various baby foods using liquid chromatography-tandem mass spectrometry|
Jae-Han Shim, Angel Yang, A. M. Abd El-Aty, Jong-Hyouk Park, Ayman Goudah, Md. Musfiqur Rahman, Jung-Ah Do
The method developed was sensitive and selective, and detected the analytes below the MRL established by the European Commission and the Korea Food and Drug Administration. The combination of QuEChERS sample preparation and LC-MS/MS analysis provided acceptable quantitative and qualitative results in baby food.
|Residue Analysis of Etoxazole in Red Pepper using Gas Chromatography: Application to Dissipation Pattern|
Sung-Woo Kim, Jin Jang, Md. Musfiqur Rahman, A. M. Abd El-Aty, Ah-Young Ko, Jong-Heui Choi, Jae-Han Shim
The dSPE of QuEChERS was replaced with an SPE cartridge, which provided a very clean chromatogram, although a small recovery percentage was obtained. The method fulfilled all validation criteria and was useful for monitoring etoxazole residues in red pepper. It can also be used and optimized for other fruit and vegetable matrices.
|Simultaneous multi-determination and transfer of eight pesticide residues from green tea leaves to infusion using gas chromatography|
Sung-Woo Kim, Soon-Kil Cho, A. M. Abd El-Aty, Md. Musfiqur Rahman, Jeong-Heui Choi, Jae-Han Shim
Acetonitrile was used as the extraction solvent with sodium chloride to enhance the partitioning of analytes into the organic phase. Recovery indicated good method accuracy and repeatability, and was within the acceptable range for residue determinations. The mere presence of pesticide residues in tea does not necessarily mean that the tea has become toxic and would pose a health hazard. We revealed that only a negligible or small percentage of pesticides in tea is transferred to the infusion.
|Matrix enhancement effect: A blessing or curse for gas chromatography?|
Jae-Han Shim, Md. Musfiqur Rahman, A. M. Abd El-Aty
A sharp, narrow, and sensitive peak is a pre-condition for a sensitive GC analysis. Therefore, a protectant is needed to protect the analyte from any type of distortion for integration and to prevent overestimation. Existing solutions do not overcome these problems completely due to limitations. As the matrix enhancement problem originated from matrix components, its solution should come from similar components.
|Novel Gpr39 Agonists: Correlation Of Binding Affinity Using Label-Free Back-Scattering Interferometry With Potency In Functional Assays|
Daniel Brown (1), Niklas Larsson (2), Ola Fjellström (3), Anders Johansson (3), Sara Lundqvist (2), Johan Brengdahl (2), and Richard J. Isaacs (1)
We describe the application of back-scattering interferometry (BSI) to the characterization of small molecule ligand binding to human GPR39 (a GPCR targeted for type-2 diabetes therapy) overexpressed in crude membrane fractions in free solution, including how BSI-derived affinity and functional assay-derived potency correlate for compounds of varying scaffolds
|Characterisation & Potential Applications of Human iPS Cell Derived Neural Progenitor Cells |
Wei J1., Gibbons G1., Lopez Alcantara S2., Dale T2., González Rueda A3., Paulsen O3. & Cox C1.
We characterised iPS cell-derived human neural progenitor cells (hNPCs) and their progeny produced using optimised methods to examine their suitability for neurobiology research.
|MAB Discovery Technology: A Smart Way to Highly Diverse and Functional Therapeutic Antibodies|
MAB Discovery GmbH developped a highly integrated process which provides diverse antibodies by starting with a high number of B cells and filtering the relevant antibodies by an early-on functional screening.
|PRESEPSIN, A SOLUBLE CD14-SUBTYPE, A POSSIBLE NEW BIOMARKER INCREASES IN SEPTIC PATIENTS’ PLASMA FROM PEDIATRIC DEPARTMENT.|
Hayato YAMAGUCHI1), Satoshi KIMURA1), Seiji FUKUOKA1), Emiko NAKAMA1), Hideyasu OTO2), Makoto INOUE2), Takashi SOGA2), Shigetaka KITAZAWA2), Yoh UMEDA2)
Increased plasma concentration of soluble CD14-subtype (presepsin) was observed in pediatric patients with bacteremia. Presepsin could be a possible biomarker of sepsis in pediatric patients, however, their reference interval in children could be lower than that of adults. More studies with larger number of samples are required to confirm the result.
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