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Acute Infective Endocarditis: Early Surgery versus Conventional Treatment
Yassar Abdullah S Alamri

Infective endocarditis (IE) refers to thew inflammation of the inner layer of the heart, the endocardium, secondary to an infectious (most commonly bacterial) agent. It affects the left side of the heart more commonly than the right. IE has an estimated incidence of 1.4 to 6.2 per 10,000 persons in the developed countries, and is most commonly caused by Staphylococcus aureus, coaguase-negative staphylococcus, Viridans group streptococci and Straptococcus bovis.

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Development of an Automated Platform for HT Cloning and Expression
Stefano Bonacci; Sara Iozzi; Scilla Buccato; Manuele Martinelli; John Telford; Domenico Maione; Roberto Petracca

Biomolecular protocols covering the whole cloning process were implemented in liquid handler robots. When compared to the manual approach, it was found that automation significantly speeds up HT cloning.

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First total synthesis of Combretastatin D-2 congeners named Isocorniculatolide A and 11-o-methylisocornicultolide
Vijaya Kumar.Tulam, Subhash Chandra Bose. Kotte, Sanjay Kumar. Hirasker, Prathama S Mainkar, P.M. Murali and K. Mukkanti.

As a part of our ongoing research in synthesizing the Biologically important Natural Products, here we are reporting First total synthesis of newly isolated isocorniculatolide A and 11-O-methyl corniculatolide A.

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Modeling Drug Disposition of Timolol in Ocular Tissues of Rabbit following Topical Eye Drops
S. Ray Chaudhuri, V. Lukacova, W.S. Woltosz

A serious disadvantage of ocular timolol therapy is the amount of drug getting into systemic circulation that adversely affects vital organ functions in elderly patients.

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Physiologically-based pharmacokinetic (PBPK) model for prediction of midazolam pharmacokinetics after intranasal administration in children
Viera Lukacova,Siladitya Ray Chaudhuri, Walter S. Woltosz , Michael B. Bolger

Study predicts midazolam absorption and pharmacokinetics (PK) after intranasal (i.n.) administration in young children.

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Physiologically-based pharmacokinetic (PBPK) models for prediction of saquinavir effect on midazolam pharmacodynamics
Viera Lukacova, Haiying Zhou, Walter S. Woltosz, Michael B. Bolger

Purpose: To predict the drug-drug interaction effect of saquinavir on midazolam pharmacodynamics (PD).

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Transporter-based In Vitro-In Vivo Extrapolation (IVIVE)
Viera Lukacova, Michael B. Bolger, Walter S. Woltosz, Neil J. Parrott, Agnès Poirier and T. Lavè

Mechanistic analysis of in vitro measurements to obtain values of kinetic parameters for drug interactions with transporters, as well as for passive diffusion through cell membranes.

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Synthesis and Characterisation of Platinum Nanoparticles Supported Vulcan Carbon Based Conductive Bipolymeric Nanoparticles
S. Balaji and B. Narayanamoorthy

The physical interactions of Platinum nanoparticles anchored on Vulcan® carbon XC – 72 (VC) over Nafion® - Polyethylene glycol - 6000 (PEG) polymer matrix nanocomposite were characterized by Fourier Transform – Infrared (FT-IR) spectra technique and surface morphology by Scanning Electron Microscope (SEM) analyses.

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Isolation of Urinary Exosomal miRNAs: Comparative Analysis of Different Methods
Sarath Kiran Channavajjhala, Marzia Rossato, Francesca Morandini, Annalisa Castagna, Flavia Bazzoni and Oliviero Olivieri

This study aims to identify and develop a robust and economical method for isolation of urinary exosomal miRNAs that can be routinely used for the analysis of miRNAs in different pathological conditions.

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Showing Results 51 - 60 of 889
Scientific News
Common Childhood Asthma Not Rooted in Allergens, Inflammation
Discovery of origins of a unique form of asthma may lead to a precision medicine approach to treatment.
Looking for the Telltale Gene
A new genetic test allows parents to peer into their unborn children's medical future.
Multiple Research Teams Unable to Confirm High-Profile Alzheimer’s Study
Teams of highly respected Alzheimer’s researchers failed to replicate what appeared to be breakthrough results for the treatment of this brain disease when they were published last year in the journal Science.
Molecular Modelling to Help Create Better, Safer Drugs
How our bodies break down the common drugs ibuprofen, diclofenac and warfarin is the subject of a new study from the University of Bristol.
Tufts CSDD Study Finds Adoption of Adaptive Clinical Trial Designs is Increasing
Report shows growing acceptance by pharmaceutical companies and regulatory agencies.
Nano-Needles for Cells
Tiny needles can force medicine into cells, even when they resist taking it.
The World’s Favourite Fruit only Better-Tasting and Longer-Lasting
Tomatoes, said to be the world's most popular fruit, can be made both better-tasting and longer-lasting thanks to UK research with purple GM varieties.
Infection Makes Mosquitoes Immune to Malaria Parasites
Study highlights the potential of using Wolbachia in malaria control.
Taming Suspect Gene Reverses Schizophrenia-like Abnormalities in Mice
NIH-funded study raises hope for recovery of some adult patients, despite early damage.
NIH Researchers Conduct First Genomic Survey of Human Skin Fungal Diversity
Location on the body surface determines fungal composition with the greatest diversity on feet.
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