|Identification and Characterization of Strain Specific Drug Target by Subtractive Genome Analysis of Methicillin Resistance Staphylococcus aureus|
Kiran Saeed and Reaz Uddin
This study aimed to identify and characterize strain specific essential protein targets, which will eventually help in the identification of druggable proteins in two strains of MRSA by using different Bioinformatic tools and databases. We adopting a subtractive genome approach within the domain of Computational Biology.
|Chia-Hsun Hsieh and Sanger Hung-Chih Lin win at CellTech 2012|
Sanger Hung-Chih Lin, Chia-Hsun Hsieh, Hung-Chih Hsu, Hung-Ming Wang, Chi-Ya Huang, Min-Hsien Wu and Ching-Ping Tseng
Chia-Hsun Hsieh and Sanger Hung-Chih Lin win at CellTech 2012
|Monitoring Protein Synthesis in Living Cells With Fluorescent Labeled tRNA FRET Pairs|
Zeev Smilansky, Sima Barhoom, Ian Farrel, Dvir Dahary, Andrew Leask, Peter Vanderklish, Marcelo Ehrlich, Barry S. Cooperman and Orna Elroy-Stein
We transfect cells with tRNAs labeled as FRET donors and acceptors. A FRET signal is generated only when a donor labeled tRNA and an acceptor-labeled tRNA come in close contact (< 7 nM), as they do on the ribosome during the elongation cycle. The intensity of the FRET signal correlates with the number of ribosomes engaged in protein synthesis, providing a real-time, live-cell assay for measuring rates of protein synthesis.
|Effect of Heat and Cold Treatment on Germination and Early Growth Stage of Terminal Heat Tolerant (WH 730) and Intolerant (RAJ 4014) Wheat Genotypes|
Om Prakash Gupta
Being second important staple food crop globally, wheat (Triticum aestivum L.) production is largely limited by heat and cold stress which adversely affects the germination, crop growth and development. Terminal heat stress is a major problem for wheat production which severely affects the grain yield.
|Kidney Genes Expression in Hypertensive ISIAH Rats|
The present study was performed to detect the key genes involved in the hypertensive phenotype manifestation in the ISIAH rats with inherited stress-induced arterial hypertension.
|Structure determination of the virulence factor AsaP1 from Aeromonas salmonicida subsp. Achromogenes|
Xenia Bogdanovic, Rajesh Kumar Singh, Gottfried J. Palm, Johanna Hentschke, Bjarnheidur K. Gudmundsdóttir & Winfried Hinrichs
Aeromonas commonly found in waters, wastewaters and mud are non-motile gram negative bacteria. Atypical strains of Aeromonas salmonicida are known to be largely responsible for causing a lethal disease in Atlantic salmons and other farmed fishes.
|Stable N-phosphorylated triazol-5-ylidenes|
Kirilchuk,A. A.; Marchenko,A. P.; Koidan, H. G.; Zarudnitskii, E. V.; Huryeva, A. N.; Yurchenko, A. A.; Kostyuk, A. N.
Considering probable generality of “carbene” mechanism for 1,3-azoles, investigation of intermediates of phosphorylation of 1,2,4-triazoles is of interest.
|Reaxys Xcelerate – Less Searching. More Discovery|
Keshav Dutt Sharma
Reaxys Xcelerate is a new premium version of Reaxys. Reaxys is a web based workflow tool for synthetic chemists. It is designed to support the optimization of synthetic processes and offers a valuable resource for accurate & validated experimental reaction & substance data.
|Automated Genomic DNA QC Ensures High Quality Data from Downstream Workflows|
Arunkumar Padmanaban, Ruediger Salowsky, Delphine Rabiller and Donna McDade Walker
The success of several genomics study depends primarily on the quality of starting material, which in most cases is the genomic DNA. The quality and quantity of the extracted genomic DNA affects the downstream applications like microarray studies, library constructions and gene expression studies.