|Safety Of The 300 IR and 500 IR Doses Of A House Dust Mite Allergen Extracts Sublingual Tablet In Adults with Allergic Rhinitis|
Hélène Nguyen, Michel Roux, Josiane Cognet-Sicé, Robert K. Zeldin
In a randomized, DBPC study in patients with HDM-associated allergic rhinitis, treatment with HDM sublingual tablets at doses of 300IR and 500IR was associated with a favorable safety profile. There was no appreciable difference in tolerability between the tested doses.
|A FastGC Proton-Transfer-Reaction Quadrupole Ion Guide Time-of-Flight (PTR-QiTOF) Mass Spectrometer|
Alfons Jordan1, Lukas Märk1, Jens Herbig1, Christian Lindinger1, Rene Gutmann1, Lukas Fischer1, Eugen Hartungen1, Simone Jürschik1, Gernot Hanel1, Philipp Sulzer1, Tilmann D. Märk1,2
In order to identify and quantify isomeric compounds independently in real-time, we introduce a novel approach where we integrate a fast GC column (“fastGC”) into a PTR-QiTOF instrument. The outstanding sensitivity of the new PTR-QiTOF (up to 4,700 cps/ppbv) is crucial for applications where time per analysis is limited, e.g. nosespace in food and flavor research. Particularly, in these fields the chemical environment is normally very complex so that a high selectivity is essential as well.
|Integrating Fluorescent Carbon Nanodot Synthesis and Optical Detection of Methylmercury|
Carlos Bendicho, Isabel Costas-Mora, Vanesa Romero, Isela Lavilla
In the last years, a great interest toward development of optical nanoprobes has arisen, so fluorescent nanomaterials have been implemented in analytical systems for the detection of several species. In this work, a novel assay that integrates the synthesis of fluorescent carbon dots (CDs) and sensing within one step, for the fast, sensitive and selective detection of methylmercury is presented.
|Capillary Electrophoresis Coupled with Micro Free Flow Electrophoresis for High Speed Two Dimensional Separations of Biological Samples|
Alexander C. Johnson, Michael T. Bowser
We propose using micro free flow electrophoresis (µFFE) as a solution to the under sampling problem.
|Impact of Molecular Surface Charge on Electrical Impedance Spectroscopy Biosensing|
Y. Ram, T. Yoetz-Kopelman, A. Freeman and Y. Shacham-Diamand
Molecular surface charge was found to be the dominant parameter when monitoring protein binding events by Electrical Impedance Spectroscopy with a charged redox couple. A biosensing device was fabricated, and a physical model was derived to explain the results.
|Cell-Mediated Cytotoxicity Assay by High-Throughput Direct Cell Counting in Microplates using Fluorescence-Based Image Cytometry|
Leo L. Chan, Srinivas S. Somanchi, Kelsey J. Rosbach, and Dean A. Lee.
In this work, we demonstrate a novel high throughput cytotoxicity detection assay using the Celigo Imaging Cytometry method. Utilizing imaging cytometry, direct cell counting of live fluorescent target cells can be performed, which is a direct method for assessment of cytotoxicity.
|Droplet-on-Demand Platform for Biochemical Screening & Drug Discovery|
L.D. van Vliet1*, F. Gielen1, A. Sinha2, B.T. Koprowski3, J.B. Edel4, X.Niu5, A.J. deMello3, F. Hollfelder1, & J. Motschman2
To demonstrate droplet on demand applications towards study of biological entities encapsulated in nanoliter droplets. Interfacing a droplet on demand platform with microfluidic chips allows for merging and dilution of droplets. This feature is applied to encapsulate yeast cells (S. cerevisiae) and multicellular organisms (C. elegans).
|Analysis of Polymers, Additives and Contaminates in Medical Devices using Pyrolysis-GCMS|
Pyrolysis GC-MS is a standard technique used to analyze industrial polymers. This poster will show the use of multiple temperature ramps to analyze for additives and contaminants, in addition to polymer identification, in several medical devices.
|Long-term on-chip storage and release of liquid reagents for diagnostic lab-on-a-chip applications|
Daniel Czurratis*, Yvonne Beyl*, Sven Zinober*, Franz Lärmer*, Roland Zengerle**
We present a concept which enables on-chip storage of liquid reagents at room temperature and allows an easy implementation into pressure driven LoC devices.
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