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Employing Design of Experiments (DoE) to Evaluate the Robustness of an Automated Content Uniformity Method for the Triple Fixed Dose Combination Tablets
Irena Maksimovic, Dongsheng Bu, David Lloyd

The Design of Experiments study was employed to optimize the operating ranges of the critical sample extraction parameters for the content uniformity determination of three actives in Triple Fixed Dose Combination tablets using Tablet Processing Workstation bench-top robotic system.

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Employing Design of Experiments (DoE) to Evaluate the Robustness of an Automated Content Uniformity Method for the Triple Fixed Dose Combination Tablets
Irena Maksimovic, Dongsheng Bu, David Lloyd

The Design of Experiments study was employed to optimize the operating ranges of the critical sample extraction parameters for the content uniformity determination of three actives in Triple Fixed Dose Combination tablets using Tablet Processing Workstation bench-top robotic system.

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A Mass Spectrometer for Elemental Analysis based on Fieldable Technologies
Hilary Brown, Jennifer Speer, John Gerling, and Kenyon Evans-Nguyen

Laser ablation and a Microwave Plasma Torch (MPT) were coupled in order to obtain elemental information from solid samples. The MPT was incorporated as a less costly and more portable alternative to the ICP. MPT was also added to help improve the signal from just the laser ablation alone.

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Accurate Determination of Moisture Content of Soft Contact Lenses by Near-Infrared (NIR) Spectroscopy
Dr. Hari Narayanan, Dr. Keith Freel

NIR spectroscopy was used to determine moisture content in soft contact lenses to and accuracy of 1%. Various sample presentation methods were used and the results were compared.

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Investigation of Chemical Contaminants in Soils Following Superstorm Sandy
Amy C Mandigo*, Dana J DiScenza*, Alison R Keimowitz†, and Neil Fitzgerald*

Investigation of Chemical Contaminants in Soils Following Superstorm Sandy

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Rapid Identification of Microorganisms by Touch Spray and Paper Spray Ambient Ionization
Ahmed M. Hamid, Alan K. Jarmusch, Valentina Pirro and R. Graham Cooks

The rapid and accurate identification of microorganisms is necessary in order to improve public health. Molecular-based identification allows for rapid patient treatment and provides more accurate diagnoses, two crucial aspects for successful treatment, yet a great challenge. In this work PS-MS, an existing ambient method, and TS-MS, a newly developed technique, are being utilized in the rapid discrimination of microorganisms (<2 min).

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Rapid analysis of 3D tumour spheroids in soft agar and on ultra-low attachment plates using a laser scanning imaging system
Anne F Hammerstein, Diana Caracino, and Paul Wylie

The requirement for better in-vitro models that are compatible with high-throughput screening campaigns has led to the development of 3D cell cultures models, especially muliticellular spheroids, which retain many of the morphological and genetic traits of tumours.
Here we describe the formation of such spheroids by two methods: on ultra-low attachment plates and in semi-solid agarose. Both methods are compatible with 96- and 384-well microplate formats.

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Combining low and high volume liquid handling capabilities for ADME screening
Joby Jenkins, Kevin Moore, Stephen Fowler, Pascal Schenk

In this study we demonstrate the integration of two liquid handlers to extend the volume dispensing range creating low-volume assay-ready plates with high accuracy and precision. This was then successfully applied to a CYP inhibition assay.

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Inverted Y Approach to Lumbosacral region - Analysis of 525 cases over 10 years
Dr Krishna Kumar and Dr Renjith Kumar

Traditional approach to lumosacral region utilizes midline incision, which often requires long incision to get sufficient exposure. We describe our experience with inverted Y approach to lumbosacral junction.

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Scientific News
Stem Cells from Nerves Forming Teeth
Findings published in the scientific journal Nature.
UTSW Cancer Researchers Identify Irreversible Inhibitor for KRAS Gene Mutation
Irreversible inhibitor for KRAS gene mutation involved in lung, colon, and pancreatic cancers.
NIH Scientists Find Six New Genetic Risk Factors for Parkinson’s
Study shows power of combining big data analysis with cutting-edge genomic techniques.
UT Southwestern Researchers Uncover New Brain Pathways
New therapies for treating Type 2 diabetes and obesity.
Mount Sinai Scientists and International Team Shed New Light on Schizophrenia
Genes and pathways identified could inform new approaches to treatment and address acute need for drug development for this disorder.
Mass Spec-Based Metabolomics Workflows to Evaluate Plant Immunity
This article reviews metabolomics studies used to evaluate plant immunity with an emphasis on mass spectrometry in its many forms.
Schizophrenia’s Genetic Skyline Rising
Suspect common variants soar from 30 to 108 - NIH-funded study.
UK Government Must Do More to Reduce Risk of vCJD Infection
Report recommends that UK Government commission a full assessment of the risks currently faced by the UK blood supply.
Future Directions of Forensic DNA Databases
With the great success of the use of forensic DNA databases, new challenges are emerging.
Current Developments in Forensic Interpretation of Mixed DNA Samples
It is of great significance to develop innovative experimental techniques and software appropriate for complex mixed DNA analysis.
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