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Fighting Blindness with 3D-NET "Drug Discovery & Development of Novel Eye Therapeutics"
Pilar Ventosa-Andrés, Nils Ohnesorge, Yolanda Fernández, Yolanda Alvarez and Breandán Kennedy

3D-NET, “Drug Discovery & Development of Novel Eye Therapeutics”, is a new European research consortium of industry and academic partners focusing efforts to enhance the discovery and development of drugs targeting ocular pathologies that lead to blindness.

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Idebenone Inhibits Cell Proliferation by Blocking of ANO1/ TMEM16A Chloride Channel in Adenocarcinoma Cells
Yohan Seo

Idebenone significantly reduced cell proliferation and induced apoptosis in PC-3, CFPAC-1, HT-29, T-84 and Calu-3 cells having CaCCs activities. These data suggest that idebenone, an ANO1/CaCC inhibitor, has potential for use in cancer therapy.

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Pressure-Based Volume Measurement Technology for In-process Measurement of Microplate Contents
John Thomas Bradshaw, Bill Gigante, Christoph Schwedes

Modern drug discovery and research labs are utilizing complex automation systems to assist in
high throughput screening of novel drug candidates. A large portion of these laboratories are
using ANSI-SBS-standard 96- and 384-well plates to achieve the necessary throughput. The volume
of sample transferred into and out of these plates can be critical to the success of assays or
validation of procedures.

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Environmental Studies Using the Tecan QC Kit and an Automated Liquid Handling System
George Rodrigues, Emily Avis, Alf Price, Verena Gerber

The study illustrates the effect of two environmental factors (air temperature and humidity) on the volumetric performance of a Tecan Freedom EVO ® pipetting robot, equipped with a liquid LiHa (Liquid Handling Arm). Tecan recommends that the EVO be installed in a controlled environment. However, some users choose to operate in less controlled conditions.

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Stable Chloroplast: Myth or Reality?
Shailesh Joshi and Dyfed Evans

Chloroplasts principally encode the photosynthetic machinery in Viridiplantae. It has long been accepted that in photosynthetic plants chloroplast genomic structure is uniquely stable as it is maternally and clonally inherited. The first chloroplast genomes sequenced supported this view. The current study was undertaken to address the potential issue of global chloroplast(in)stability.

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Validation of Collection and Extraction Methods of Saliva for Use in Biomarker Research
Sarah E. Hurst and Brandon T. Hall

This poster investigates the collection and extraction methods of saliva for use in biomarker research.

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Rapid Detection of Somatic Mutations in Cancer Genes
Michael J. Powell et. al.,

Rapid higly sensitive detection of tumor gene mutations in DNA derived from FFPE or plasma samples can be achieved with QClamp PCR technology.

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New Microarray Slides Capable of Enhancing Fluorescence
Baumgold, Jesse

Slides for proteomic microarrays with imbedded nanoparticles that enhance fluoresce by ~ 30-fold via a plasmonic effect. These slides are useful for enhancing fluorescence of protein or peptide microarrays.

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Development of a Microfluidic Device for Sperm Movement
Shweta Bhagwat (b), Vibha Jayaraj* (b), Priyanka Parte (a), Sameer Jadhav (b)

We show the design of a device for studying sperm chemotaxis and the testing of different chemicals as a source of chemoattractants.

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Scientific News
Roll Up Your Screen and Stow it Away?
TAU researchers develop molecular backbone of super-slim, bendable digital displays.
Saccharin Shows Promise as Cancer Inhibitor
Researchers have found that the artificial sweetener can inhibit cancer cell growth.
Study Shows Quantose IR™ Measures Insulin Sensitivity Better
Results were recently published online by the Journal of Clinical Endocrinology & Metabolism.
Drinking Raw Milk Dramatically Increases Risk for Foodborne Illness, Analysis Finds
Researchers discourage the consumption of raw milk, especially by children, pregnant women and the elderly.
Immunomagnetic Assay On-a-Chip Captures, Analyzes Circulating Tumor Cells
Dartmouth researchers and bioengineers develop novel system to improve cancer treatment.
Genome Study Predicts DNA of the Whole of Iceland
Large genome databases are starting to reveal critical health information-even about people who have not contributed their DNA.
How the Human Immune System Keeps TB at Bay
Scientists create model of host, bacteria behavior in latent TB infection.
MDC Researchers Greatly Increase Precision of New Genome Editing Tool
“One of the hottest topics in science and an innovative field”.
‘Atomic Chicken-Wire’ Is Key To Faster DNA Sequencing
An unusual and very exciting form of carbon - that can be created by drawing on paper- looks to hold the key to real-time, high throughput DNA sequencing, a technique that would revolutionise medical research and testing.
The Switch That Might Tame The Most Aggressive Of Breast Cancers
Garvan researchers have found that so-called ‘triple-negative breast cancers’ are two distinct diseases that likely originate from different cell types. They have also found a gene that drives the aggressive disease, and hope to find a way to ‘switch it off’.
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