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Amplicon Based 16S Ribosomal RNA Sequencing and Genus Identification
*Jan Risinger, *Lindsey Renken, +Josh Hill, +Noushin Ghaffari, PhD, +Richard P. Metz, PhD, +Charles D. Johnson, PhD, *Masoud M. Toloue, Ph

Rapid determination of highly complex bacterial populations through targeted amplification of 16S rRNA V1 - V3 hypervariable regions can provide an accurate gauge of diversity at taxonomic hierarchies as low as the genus level.

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Fighting Blindness with 3D-NET "Drug Discovery & Development of Novel Eye Therapeutics"
Pilar Ventosa-Andrés, Nils Ohnesorge, Yolanda Fernández, Yolanda Alvarez and Breandán Kennedy

3D-NET, “Drug Discovery & Development of Novel Eye Therapeutics”, is a new European research consortium of industry and academic partners focusing efforts to enhance the discovery and development of drugs targeting ocular pathologies that lead to blindness.

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Direct flow synthesis of H2O2 catalysed by palladium supported on sulfonated polystyrene resins
Aurélie Plas, Eduard Dolušic and Steve Lanners

Development of a continuous microfluidic process for the production of hydrogen peroxide by direct synthesis with a minimalised ecological footprint.

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Idebenone Inhibits Cell Proliferation by Blocking of ANO1/ TMEM16A Chloride Channel in Adenocarcinoma Cells
Yohan Seo

Idebenone significantly reduced cell proliferation and induced apoptosis in PC-3, CFPAC-1, HT-29, T-84 and Calu-3 cells having CaCCs activities. These data suggest that idebenone, an ANO1/CaCC inhibitor, has potential for use in cancer therapy.

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Pressure-Based Volume Measurement Technology for In-process Measurement of Microplate Contents
John Thomas Bradshaw, Bill Gigante, Christoph Schwedes

Modern drug discovery and research labs are utilizing complex automation systems to assist in
high throughput screening of novel drug candidates. A large portion of these laboratories are
using ANSI-SBS-standard 96- and 384-well plates to achieve the necessary throughput. The volume
of sample transferred into and out of these plates can be critical to the success of assays or
validation of procedures.

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Environmental Studies Using the Tecan QC Kit and an Automated Liquid Handling System
George Rodrigues, Emily Avis, Alf Price, Verena Gerber

The study illustrates the effect of two environmental factors (air temperature and humidity) on the volumetric performance of a Tecan Freedom EVO ® pipetting robot, equipped with a liquid LiHa (Liquid Handling Arm). Tecan recommends that the EVO be installed in a controlled environment. However, some users choose to operate in less controlled conditions.

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Stable Chloroplast: Myth or Reality?
Shailesh Joshi and Dyfed Evans

Chloroplasts principally encode the photosynthetic machinery in Viridiplantae. It has long been accepted that in photosynthetic plants chloroplast genomic structure is uniquely stable as it is maternally and clonally inherited. The first chloroplast genomes sequenced supported this view. The current study was undertaken to address the potential issue of global chloroplast(in)stability.

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Validation of Collection and Extraction Methods of Saliva for Use in Biomarker Research
Sarah E. Hurst and Brandon T. Hall

This poster investigates the collection and extraction methods of saliva for use in biomarker research.

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Rapid Detection of Somatic Mutations in Cancer Genes
Michael J. Powell et. al.,

Rapid higly sensitive detection of tumor gene mutations in DNA derived from FFPE or plasma samples can be achieved with QClamp PCR technology.

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Scientific News
Diabetes Drug Found In Freshwater Is Potential Source Of Intersex Fish
Study shows exposure to metforim causes physical changes in male fish.
An end To Cancer Pain? Dentistry Researcher Finds The Pain Trigger
Study identifies TMPRSS2 as potential culprit behind the most severe forms of cancer pain.
How To Identify Drugs That Work Best For Each Patient
Implantable device could allow doctors to test cancer drugs in patients before prescribing chemotherapy.
Unique Insight into the Function of a Key Muscle Protein
In a muscle every protein has to pull its weight. Thanks to high-resolution structural analysis the role of the essential muscle protein a-Actinin is now better understood.
Gene-Editing Technique Offers Hope For Hereditary Diseases
Salk scientists use molecular "scissors" to eliminate mitochondrial mutations in eggs and embryos.
Promising Stem Cell Therapy
Animal model of breast-to-brain cancer spread allows testing of therapeutic-cell approach.
Gene Editing Corrects Mutation In Cystic Fibrosis
Yale researchers successfully corrected the most common mutation in the gene that causes cystic fibrosis, a lethal genetic disorder.
Hundreds Of Cancer Possibilities Arise From Common Skin Mole Mutation
A Houston Methodist-led team of international scientists has identified hundreds of possible new genes in mice that could transform benign skin growths into deadly melanomas.
Tapeworm Drug Shows Promise Against MRSA
A new study shows that a drug already approved to fight tapeworms in people, effectively treated MRSA superbugs in lab cultures and in infected nematode worms.
First Liquid Nanolaser Developed
Technology could lead to new way of doing ‘lab on a chip’ medical diagnostics.
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