|Modeling Drug Disposition of Timolol in Ocular Tissues of Rabbit following Topical Eye Drops|
S. Ray Chaudhuri, V. Lukacova, W.S. Woltosz
A serious disadvantage of ocular timolol therapy is the amount of drug getting into systemic circulation that adversely affects vital organ functions in elderly patients.
|Physiologically-based pharmacokinetic (PBPK) model for prediction of midazolam pharmacokinetics after intranasal administration in children|
Viera Lukacova,Siladitya Ray Chaudhuri, Walter S. Woltosz , Michael B. Bolger
Study predicts midazolam absorption and pharmacokinetics (PK) after intranasal (i.n.) administration in young children.
|Physiologically-based pharmacokinetic (PBPK) models for prediction of saquinavir effect on midazolam pharmacodynamics|
Viera Lukacova, Haiying Zhou, Walter S. Woltosz, Michael B. Bolger
Purpose: To predict the drug-drug interaction effect of saquinavir on midazolam pharmacodynamics (PD).
|Transporter-based In Vitro-In Vivo Extrapolation (IVIVE)|
Viera Lukacova, Michael B. Bolger, Walter S. Woltosz, Neil J. Parrott, Agnès Poirier and T. Lavè
Mechanistic analysis of in vitro measurements to obtain values of kinetic parameters for drug interactions with transporters, as well as for passive diffusion through cell membranes.
|Synthesis and Characterisation of Platinum Nanoparticles Supported Vulcan Carbon Based Conductive Bipolymeric Nanoparticles|
S. Balaji and B. Narayanamoorthy
The physical interactions of Platinum nanoparticles anchored on Vulcan® carbon XC – 72 (VC) over Nafion® - Polyethylene glycol - 6000 (PEG) polymer matrix nanocomposite were characterized by Fourier Transform – Infrared (FT-IR) spectra technique and surface morphology by Scanning Electron Microscope (SEM) analyses.
|Isolation of Urinary Exosomal miRNAs: Comparative Analysis of Different Methods|
Sarath Kiran Channavajjhala, Marzia Rossato, Francesca Morandini, Annalisa Castagna, Flavia Bazzoni and Oliviero Olivieri
This study aims to identify and develop a robust and economical method for isolation of urinary exosomal miRNAs that can be routinely used for the analysis of miRNAs in different pathological conditions.
|Automated Tyrosine Kinase Inhibitor Cardiotoxicity Assay in Zebrafish|
Olaia Holgado, Juan Maria Virto, Isaskun Ibarbia, Patrice Dubreuil, Didier Pez, Ainhoa Letamendia, Martine Humbert, Alain Moussy, Carles Callol-Massot
The zebrafish embryos have recently gained relevance in biomedical research thanks to some of its characteristics including embryo transparency. Combined with the possibility to adapt the model with an automatic device and the reduced cost associated to each assay, the model is an ideal killer experiment in early phases of drug discovery as well as a novel method to increase the selection arguments to reduce the candidates to enter into the Drug Development process.
|ISMTR-283 Protects Human Bone Marrow Progenitors from the Lethal Effects of Ionizing Radiation|
Clarke E, Traynor-Kaplan A
Bone Marrow (BM) is extremely susceptible to radiation damage. BM from matched donors is often used to ‘rescue’ patients following medical radiation for leukemia. However, in the event of accidental/environmental radiation exposure, the ability to identify appropriate donors in a timely manner is rarely possible. Using CFC assays, we evaluated a small molecule compound (ISMTR-283) for its potential to protect the marrow progenitor cells and microenvironment from radiation damage.
|Metal Polymers, A Glue to Immobilise Proteins Onto Synthetic Surfaces|
Abernethy N, Chung E, Fontanelle BT, Gao Y, Jennins D, Koudijs MM, Lim D, Yang L, Ling T, Vukovic P, Wong A, Maeji, NJ
The main objective of this work was to develop a surface chemistry which maintains protein function and orientation per unit surface area, regardless of the surface used.