DPPH scavenging activities of selected flavonoids and their mixtures
Keywords: Quercetin, Luteolin, Galangin, DPPH, synergy
Flavonoids are secondary plant metabolites, the most common phenolics compounds and are widely distributed in plants. Dietary sources of flavonoids are parsley, blueberries, black tea, wine and many other plants or fruits. Flavonoids possess antioxidative, anti-inflammatory, anti-cancer, antibacterial and many other activities. The aim of this study was to investigate the DPPH scavenging activities of selected flavonoids (quercetin, galangin and luteolin) and their mixtures. These ones consisted of two or three substances in equimolar ratio. We tried to determine possible synergistic or antagonistic effects. According to the results of the present study, quercetin has the highest scavenging activity compared to the two other flavonoids. Moreover, the combination of luteolin and quercetin showed to have the highest activity after quercetin, but having only nearly additive effect. From the point of view of combination index the triple combination has the best value but still appearing to have nearly additive effect. No synergy was detected between any of the flavonoid combinations. DPPH scavenging activities of mentioned three flavonoids equimolar mixtures are described for the first time to our best knowledge.
Flavonoids are secondary plant metabolites, the most common phenolics compounds and are widely distributed in plants. Dietary sources of flavonoids are parsley, blueberries, black tea, wine and many other plants or fruits. Flavonoids possess antioxidative, anti-inflammatory, anti-cancer, antibacterial and many other activities. The aim of this study was to investigate the DPPH scavenging activities of selected flavonoids (quercetin, galangin and luteolin) and their mixtures. These ones consisted of two or three substances in equimolar ratio. We tried to determine possible synergistic or antagonistic effects. According to the results of the present study, quercetin has the highest scavenging activity compared to the two other flavonoids. Moreover, the combination of luteolin and quercetin showed to have the highest activity after quercetin, but having only nearly additive effect. From the point of view of combination index the triple combination has the best value but still appearing to have nearly additive effect. No synergy was detected between any of the flavonoid combinations. DPPH scavenging activities of mentioned three flavonoids equimolar mixtures are described for the first time to our best knowledge.
