Touching BACE. How Inhibiting β-Amyloid Production by Steric Hindrance with a Novel Immunotherapy Improves Memory in PDAPP Mice
We have developed a novel monoclonal antibody, 2B3, which targets APP at the β- secretase cleavage site, inhibiting Aβ production by steric hindrance.
The PDAPP mouse model of AD overexpresses a familial APP mutation is reported to show an age-dependent rise in levels of Aβ and cognitive deficits.
Aβ has been observed to increase NMDA receptor phosphorylation leading to excitotoxicity and cognitive impairment in hAPP mouse models of AD.
The PDAPP mouse model of AD overexpresses a familial APP mutation is reported to show an age-dependent rise in levels of Aβ and cognitive deficits.
Aβ has been observed to increase NMDA receptor phosphorylation leading to excitotoxicity and cognitive impairment in hAPP mouse models of AD.
