Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>Products>This Product
  Products


IonWorks Barracuda Automated Patch Clamp System

Product Description
The IonWorks family of instruments targets the unmet need for a low cost, high throughput, direct electrophysiological assay for ion channel targets. Unlike indirect assays, such as fluorescent or ion flux assays, that are surrogate measure of ion channel activity, IonWorks instrumentation measures ionic currents directly and controls the membrane voltage inside a cell. The IonWorks® Barracuda™ System builds on the capabilities demonstrated by the IonWorks Quattro system while adding the capability to measure rapidly desensitizing ligand-gated channels. With the IonWorks Barracuda System a throughput of over 10,000 data points per day can be achieved with both voltage- and ligand-gated ion channels (VGICs and LGICs). The system features Population Patch Clamp (PPC) technology which improves data consistency and success rates by mitigating the biological variability seen when measuring from single cells. PPC has enabled the primary screening of large directed libraries as well as novel assays including channel opener assays and multiplexing multiple ion channel targets in a single assay. The IonWorks Barracuda System supports both PPC and single hole (SH) recording modes. SH recording mode is important where information must be obtained from individual cells during ion channel assay optimization and in applications such as the selection of individual clones for cell line optimization.

The IonWorks Barracuda System features a 384-well assay plate (our PatchPlate™ consumable) with a uniquely designed recording chamber that is optimized for rapid fluid exchange. This is especially important when measuring fast LGICs in order to resolve the rapid activation and desensitization kinetics of their ionic currents. The system combines 384 discreet amplifiers and a 384-channel pipettor head for the recording of ionic currents in all wells simultaneously. The parallel recording and fluidics configuration allow for the generation of over 10,000 data points per day. A typical ion channel assay with one compound addition per well can be completed in as little as 20 minutes. The system also allows up to eight compound additions per well further increasing the throughput and reducing the cost per data point. The IonWorks Barracuda System is ideal for primary screening of large directed compound libraries. Further, with the capability to add multiple compound additions per well, for example increasing concentrations on a dose response curve, the system is also well suited for compound profiling and safety assessment.
Product IonWorks Barracuda Automated Patch Clamp System
Company Molecular Devices Product Directory
Price Request a quote
More Information View company product page
Catalog Number Unspecified
Quantity Unspecified
Company Logo

Molecular Devices Product Directory
1311 Orleans Drive Sunnyvale, CA 94089-11361 United States

Tel: 1-800-635-5577
Fax: 1-408-548-6439
Email: om@moldev.com



Scientific News
Liquid Biopsies: Miracle Diagnostic or Next New Fad?
Thanks to the development of highly specific gene-amplification and sequencing technologies liquid biopsies access more biomarkers relevant to more cancers than ever before.
JPK NanoWizard® Applied to a Wide Range of Research
The NanoWizard® AFM from JPK is applied for interdisciplinary research at the University of South Australia for applications including smart wound healing and how plants can protect themselves from toxins.
Mutations in DNA-Repair Genes Found in Advanced Prostate Cancers
New findings indicate that nearly 12% of male advanced prostate cancer sufferers have inherited mutation in DNA-repair genes.
Protein Boosts Rice Yield by 54%
Over-expression of a natural protein in rice plants led to a 54% increase in crop yield and 40% increase in nitrogen-use efficiency.
Ice Bucket Challenge Instrumental in Gene Discovery
Donations from the ALS Ice Bucket Chellenge allowed for the largest-ever study of inherited ALS, which identified a new ALS gene.
Genetic Variability in Cell Bank Lots
Researchers working with cancer cells from the same cell bank acquired at the same time, found that the cells were genetically different.
Triple-Action Therapy Patch Shows Promise
Patch that delivers drug, gene, and light-based therapy to tumor sites shows promising results in mice.
Soil Nitrogen Age Important for Precision Agriculture
Calculating the age of nitrogen in corn and soybean fields could lead to improved fertilizer application techniques.
Targeting Autoimmunity
Researchers have developed a strategy to treat a rare autoimmune disease which could lead to treatments of other autoimmune diseases.
Molecule May Affect Gaucher, Parkinson's Disease
Research has identified a molecule that restores activity of a dysfunctional enzyme linked to Gaucher and Parkinson's disease.
Scroll Up
Scroll Down

Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,900+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!