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Threshold Contaminant Detection System

Product Description

"The production of biopharmaceuticals, such as monoclonal antibodies, recombinant proteins, vaccines, and nucleic acids requires special techniques and quality control methods. Electrophoresis, chromatography, and immunochemical methods are commonly used together to monitor and optimize the biopharmaceutical manufacturing process. The Threshold®  System is a dedicated platform for the rapid quantitation of biopharmaceutical products or contaminants from bioreactors/fermenters, downstream processing and final product quality control. The system is ideal for the quantitation of proteins, peptides and non-sequence specific total DNA.

The Threshold System measures a wide range of analytes such as host cell proteins, bovine contaminants (BSA, IgG, transferring and insulin), Protein A and G, and total DNA at low concentrations. To simplify assay development, all reagents are supplied in pre-packaged kits to label your antibodies or commercially available antibodies. To optimize the interaction between the antigen and antibody, binding occurs freely in solution where the molecules are maintained in their native conformation and antibodies retain 100% of their activity.  Assay sensitivity for proteins and peptides is typically equal to or better than radioimmunassays and at least 10X better than ELISA assays. When measuring DNA, sensitivity as low as 2 pg can be achieved. Typically assays have a dynamic range of 2 logs or greater, so fewer sample dilutions are required for accurate quantitation. Assays are fast and are complete in as little as 90 seconds.

Optional Threshold Enterprise Software is available with a complete validation package and security tools that comply with GLP/GMP/FDA 21 CFR Part 11 requirements. The Threshold System's proven advantages of sensitivity, speed, reproducibility and reliability, as well as MDC's strong technical experience and support, have elevated this system to be the gold standard in the industry."

Product Threshold Contaminant Detection System
Company Molecular Devices Product Directory
Price Request a quote
More Information View company product page
Catalog Number Unspecified
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Molecular Devices Product Directory
1311 Orleans Drive Sunnyvale, CA 94089-11361 United States

Tel: 1-800-635-5577
Fax: 1-408-548-6439

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