The MaxDiscovery™ Human IL-10 ELISA Test Kit is designed for quantitative determination of the concentration of human IL-10 in serum, plasma, and cell culture supernatant. Human interleukin 10 (IL-10) is a homodimeric protein with subunits having a length of 160 amino acids. It shows 73 percent amino acid homology with murine IL-10. It is produced by activated CD8 + peripheral blood T cells, by T-helper CD4 + T cell clones after both antigen-specific and polyclonal activation, by B-cell lymphomas, and by monocytes following cell activation by bacterial lipopolysaccharides and mast cells. IL-10 inhibits the synthesis of a number of cytokines such as IL-2 and TNF-ß in Th1 T-helper cells but not of Th2 T-helper cells. IL-10 also inhibits mitogen or anti-CD3 induced proliferation of T cells in the presence of accessory cells and reduces the production of IFN-? and IL-2.
Retractable Protein Nanoneedles The ability to control the transfer of molecules through cellular membranes is an important function in synthetic biology; a new study from researchers at Harvard’s Wyss Institute for Biologically Inspired Engineering and Harvard Medical School (HMS) introduces a novel mechanical method for controlling release of molecules inside cells.Leukemia’s Surroundings Key to its Growth Researchers at The University of Texas at Austin have discovered that a type of cancer found primarily in children can grow only when signaled to do so by other nearby cells that are noncancerous.Common Cell Transformed into Master Heart Cell By genetically reprogramming the most common type of cell in mammalian connective tissue, researchers at the University of Wisconsin—Madison have generated master heart cells — primitive progenitors that form the developing heart.‘Smelling’ Prostate Cancer A research team from the University of Liverpool and the University of the West of England (UWE Bristol) has reached an important milestone towards creating a urine diagnostic test for prostate cancer that could mean that invasive diagnostic procedures that men currently undergo eventually become a thing of the past.Genetic Mutation that Prevents Diabetes Complications The most significant complications of diabetes include diabetic retinal disease, or retinopathy, and diabetic kidney disease, or nephropathy. Both involve damaged capillaries.A Crystal Clear View of Biomolecules Fundamental discovery triggers paradigm shift in crystallography.Could the Food we Eat Affect Our Genes? Almost all of our genes may be influenced by the food we eat, according to new research.NIH Seeks Research Applications to Study Zika in Pregnancy, Developing Fetus Institute has announced that the new effort seeks to understand virus effect on reproduction and child development.Iron in the Blood Could Cause Cell Damage Concentrations of iron similar to those delivered through standard treatments can trigger DNA damage within 10 minutes, when given to cells in the laboratory. Neanderthal DNA Influences Human Disease Risk Large-scale, evolutionary analysis compares genetic data alongside electronic health records.