Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>Products>This Product
  Products


MaxDiscovery™ Human IL-15 ELISA Test Kit

Product Description
The MaxDiscovery™ Human IL-15 ELISA Test Kit is designed for quantitative determination of the concentration of human IL-15 in serum, plasma, and cell culture supernatant. Human interleukin 15 (IL-15) is a protein of 114 amino acids after cleavage of a 48 amino acid signal peptide. An alternative splice form of IL-15 has also been identified with an identical mature sequence, but a shorter signal sequence. Interestingly, the shorter prepeptide is not secreted and may represent a functional intracellular molecule. In addition, a membrane-bound form of IL-15 has also been reported, which may be an important physiological form of the molecule. Human IL-15 has 97% and 73% amino acid sequence identity with simian and mouse IL-15, respectively. Both human and simian IL-15s are active on mouse cells. IL-15 is a novel cytokine that shares many biological properties with IL-2. Originally identified in media conditioned by a monkey kidney epithelial cell line (CVI/EBNA) based on its mitogenic activity on the mouse T cell line (CTLL-2), IL-15 was independently discovered as a cytokine produced by a human adult T-cell leukemia cell line (HuT-102) that stimulated T cell proliferation and was designated IL-T . High-affinity cell surface receptors for IL-15 have been detected on a variety of cells including T cells, B cells, and NK cells as well as on non-lymphoid cells. The IL-15 receptor is composed of three molecules; an IL-15 specific a-chain of 237 amino acids, plus a ß-chain and ?-chain that is shared by the receptor system for IL-2. The a-chain binds IL-15 with high affinity. It shows 54% amino acid sequence identity with mouse IL-15 R and exists in multiple alternatively spliced forms. Although the IL-15 receptor is composed of 3 chains, IL-15 will signal through a dimer and the ß?-chain itself may have multiple functions. IL-15 has biological activities similar to IL-2 and has been shown to stimulate the growth of natural killer cells, activated peripheral blood T lymphocytes, tumor infiltrating lymphocytes (TILs), and B cells. In addition, IL-15 has also been shown to be a chemoattractant for human blood T lymphocytes and to induce both lymphokine-activated killer (LAK) activity in NK cells and the generation of cytolytic effector cells. IL-15 apparently also has effects on cells not involved in immune responses. Skeletal muscle cells express IL-15 and IL-15 R mRNAs and respond to the addition of IL-15.
Product MaxDiscovery™ Human IL-15 ELISA Test Kit
Company BIOO Scientific - Product Directory
Price Request a quote
More Information View company product page
Catalog Number 2122-01
Quantity 1 x 96 wells
Company Logo

BIOO Scientific - Product Directory
3913 Todd Lane Suite 312 Austin, TX 78744, USA

Tel: +1 512-707-8993
Fax: +1 512-707-8122
Email: info@biooscientific.com



Scientific News
The Rise of 3D Cell Culture and in vitro Model Systems for Drug Discovery and Toxicology
An overview of the current technology and the challenges and benefits over 2D cell culture models plus some of the latest advances relating to human health research.
New NIH-EPA Research Centers to Study Environmental Health Disparities
Scientists will partner with community organizations to study these concerns and develop culturally appropriate ways to reduce exposure to harmful environmental conditions.
Structure of Essential Digestive Enzyme Uncovered
Using a powerful combination of techniques from biophysics to mathematics, researchers have revealed new insights into the mechanism of a liver enzyme that is critical for human health.
Air Pollution Linked to Heart Disease
10-year project revealed air pollutants accelerate plaque build-up in arteries to the heart.
Getting a Better Look at How HIV Infects and Takes Over its Host Cells
A new approach, developed by a team of researchers led by The Rockefeller University and The Aaron Diamond AIDS Research Center (ADARC), offers an unprecedented view of how a virus infects and appropriates a host cell, step by step.
Following Tricky Triclosan
Antibacterial product flows through streams, crops.
Vitamin A May Help Improve Pancreatic Cancer Chemotherapy
The addition of high doses of a form of vitamin A could help make chemotherapy more successful in treating pancreatic cancer, according to an early study by Queen Mary University of London (QMUL).
Poverty Marks a Gene, Predicting Depression
New study of high-risk teens reveals a biological pathway for depression.
World’s Largest Coral Gene Database
‘Genetic toolkit’ will help shed light on which species survive climate change.
A Boost for Regenerative Medicine
Growing tissues and organs in the lab for transplantation into patients could become easier after scientists discovered an effective way to produce three-dimensional networks of blood vessels, vital for tissue survival yet a current stumbling block in regenerative medicine.
Scroll Up
Scroll Down

Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,100+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!