Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>Products>This Product
  Products


MaxDiscovery™ Human IL-16 ELISA Test Kit

Product Description
The MaxDiscovery™ Human IL-16 ELISA Test Kit is designed for quantitative determination of the concentration of human IL-16 in serum, plasma, and cell culture supernatant. Human interleukin 16 (IL-16), known as lymphocyte chemoattractant factor (LCF), was originally identified as a homotetramer consisting of individual 14 kDa monomers of 130 amino acids each. It is synthesized as a 68 kDa precursor (pro-IL-16) of approximately 631 amino acids lacking a signal peptide. The human IL-16 sequence shows more than 90% homology to those of nonhuman primates. It is a unique cytokine with no significant sequence homology to other well-characterized cytokines or chemokines. IL-16 is produced by epithelial cells, mast cells, lymphocytes, macrophages, synovial fibroblasts, and eosinophils. IL-16 mRNA is constitutively expressed in both CD4+ and CD8+ cells; however, transcription is induced in T lymphocytes upon exposure to antigen or mitogen. IL-16 may also be secreted by activated CD8+ cells in response to histamine or serotonin. IL-16 expression has been linked to inflammation processes in asthma, rheumatoid arthritis, systemic lupus erythematosus, colitis, atopic dermatitis, and multiple sclerosis. For example, the expression of IL-16 directly correlates with the number of infiltrating CD4+ T cells in asthmatic epithelium. IL-16 is a proinflammatory cytokine with chemotactic for CD4+ T lymphocytes, monocytes and eosinophils. In addition, IL-16 can upregulate IL-2 receptor and HLA-DR expression, inhibit T cell receptor (TcR)/CD3-dependent activation and promote repression of HIV-1 transcription. Recombinant pro-IL-16 polypeptides are specifically cleaved in CD8+ cell lysates suggesting that the actual secreted form of IL-16 may be smaller than the originally published 130 amino acid form. In CD8+ T cells, active caspase-3 cleaves pro-IL-16 producing a biologically active, secreted form of IL-16 (i.e. representing 121 C-terminal amino acid residues of pro-IL-16). Expression of CD4 is required for mediating IL-16 functions. Interaction between IL-16 and CD4 can specifically initiate an increase in intracytoplasmic calcium and inositol trisphosphate, activation of p56lck, and translocation of protein kinase C from the cytosol to the cell membrane. The region of CD4 that binds IL-16 has been identified within the D4 domain, overlapping the structure involved in CD4 dimer formation.
Product MaxDiscovery™ Human IL-16 ELISA Test Kit
Company BIOO Scientific - Product Directory
Price Request a quote
More Information View company product page
Catalog Number 2123-01
Quantity 1 x 96 wells
Company Logo

BIOO Scientific - Product Directory
3913 Todd Lane Suite 312 Austin, TX 78744, USA

Tel: +1 512-707-8993
Fax: +1 512-707-8122
Email: info@biooscientific.com



Scientific News
Breaking Cell Barriers with Retractable Protein Nanoneedles
Adapting a bacterial structure, institute researchers have developed protein actuators that can mechanically puncture cells.
Gene Signature could Lead to a New Way of Diagnosing Lyme Disease
Lyme disease patients had distinctive gene signatures that persisted for at least three weeks, even after they had taken the antibiotics.
Retractable Protein Nanoneedles
The ability to control the transfer of molecules through cellular membranes is an important function in synthetic biology; a new study from researchers at Harvard’s Wyss Institute for Biologically Inspired Engineering and Harvard Medical School (HMS) introduces a novel mechanical method for controlling release of molecules inside cells.
Leukemia’s Surroundings Key to its Growth
Researchers at The University of Texas at Austin have discovered that a type of cancer found primarily in children can grow only when signaled to do so by other nearby cells that are noncancerous.
Common Cell Transformed into Master Heart Cell
By genetically reprogramming the most common type of cell in mammalian connective tissue, researchers at the University of Wisconsin—Madison have generated master heart cells — primitive progenitors that form the developing heart.
‘Smelling’ Prostate Cancer
A research team from the University of Liverpool and the University of the West of England (UWE Bristol) has reached an important milestone towards creating a urine diagnostic test for prostate cancer that could mean that invasive diagnostic procedures that men currently undergo eventually become a thing of the past.
Genetic Mutation that Prevents Diabetes Complications
The most significant complications of diabetes include diabetic retinal disease, or retinopathy, and diabetic kidney disease, or nephropathy. Both involve damaged capillaries.
A Crystal Clear View of Biomolecules
Fundamental discovery triggers paradigm shift in crystallography.
Could the Food we Eat Affect Our Genes?
Almost all of our genes may be influenced by the food we eat, according to new research.
NIH Seeks Research Applications to Study Zika in Pregnancy, Developing Fetus
Institute has announced that the new effort seeks to understand virus effect on reproduction and child development.
Scroll Up
Scroll Down

Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!