Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>Products>This Product
  Products


MaxDiscovery™ Human IL-16 ELISA Test Kit

Product Description
The MaxDiscovery™ Human IL-16 ELISA Test Kit is designed for quantitative determination of the concentration of human IL-16 in serum, plasma, and cell culture supernatant. Human interleukin 16 (IL-16), known as lymphocyte chemoattractant factor (LCF), was originally identified as a homotetramer consisting of individual 14 kDa monomers of 130 amino acids each. It is synthesized as a 68 kDa precursor (pro-IL-16) of approximately 631 amino acids lacking a signal peptide. The human IL-16 sequence shows more than 90% homology to those of nonhuman primates. It is a unique cytokine with no significant sequence homology to other well-characterized cytokines or chemokines. IL-16 is produced by epithelial cells, mast cells, lymphocytes, macrophages, synovial fibroblasts, and eosinophils. IL-16 mRNA is constitutively expressed in both CD4+ and CD8+ cells; however, transcription is induced in T lymphocytes upon exposure to antigen or mitogen. IL-16 may also be secreted by activated CD8+ cells in response to histamine or serotonin. IL-16 expression has been linked to inflammation processes in asthma, rheumatoid arthritis, systemic lupus erythematosus, colitis, atopic dermatitis, and multiple sclerosis. For example, the expression of IL-16 directly correlates with the number of infiltrating CD4+ T cells in asthmatic epithelium. IL-16 is a proinflammatory cytokine with chemotactic for CD4+ T lymphocytes, monocytes and eosinophils. In addition, IL-16 can upregulate IL-2 receptor and HLA-DR expression, inhibit T cell receptor (TcR)/CD3-dependent activation and promote repression of HIV-1 transcription. Recombinant pro-IL-16 polypeptides are specifically cleaved in CD8+ cell lysates suggesting that the actual secreted form of IL-16 may be smaller than the originally published 130 amino acid form. In CD8+ T cells, active caspase-3 cleaves pro-IL-16 producing a biologically active, secreted form of IL-16 (i.e. representing 121 C-terminal amino acid residues of pro-IL-16). Expression of CD4 is required for mediating IL-16 functions. Interaction between IL-16 and CD4 can specifically initiate an increase in intracytoplasmic calcium and inositol trisphosphate, activation of p56lck, and translocation of protein kinase C from the cytosol to the cell membrane. The region of CD4 that binds IL-16 has been identified within the D4 domain, overlapping the structure involved in CD4 dimer formation.
Product MaxDiscovery™ Human IL-16 ELISA Test Kit
Company BIOO Scientific - Product Directory
Price Request a quote
More Information View company product page
Catalog Number 2123-01
Quantity 1 x 96 wells
Company Logo

BIOO Scientific - Product Directory
3913 Todd Lane Suite 312 Austin, TX 78744, USA

Tel: +1 512-707-8993
Fax: +1 512-707-8122
Email: info@biooscientific.com



Scientific News
The Rise of 3D Cell Culture and in vitro Model Systems for Drug Discovery and Toxicology
An overview of the current technology and the challenges and benefits over 2D cell culture models plus some of the latest advances relating to human health research.
Grant Supports Project To Develop Simple Test To Screen For Cervical Cancer
UCLA Engineering announces funding from Bill and Melinda Gates Foundation.
Injecting New Life into Old Antibiotics
A new fully synthetic way to make a class of antibiotics called macrolides from simple building blocks is set to open up a new front in the fight against antimicrobial drug resistance.
Insight into Bacterial Resilience and Antibiotic Targets
Variant of CRISPR technology paired with computerized imaging reveals essential gene networks in bacteria.
Advancing Protein Visualization
Cryo-EM methods can determine structures of small proteins bound to potential drug candidates.
Alzheimer’s Protein Serves as Natural Antibiotic
Alzheimer's-associated amyloid plaques may be part of natural process to trap microbes, findings suggest new therapeutic strategies.
Slime Mold Reveals Clues to Immune Cells’ Directional Abilities
Study from UC San Diego identifies a protein involved in the directional ability of a slime mold.
How Do You Kill A Malaria Parasite?
Drexel University scientists have discovered an unusual mechanism for how two new antimalarial drugs operate: They give the parasite’s skin a boost in cholesterol, making it unable to traverse the narrow labyrinths of the human bloodstream. The drugs also seem to trick the parasite into reproducing prematurely.
Illuminating Hidden Gene Regulators
New super-resolution technique visualizes important role of short-lived enzyme clusters.
Supressing Intenstinal Analphylaxis in Peanut Allergy
Study from National Jewish Health shows that blockade of histamine receptors suppresses intestinal anaphylaxis in peanut allergy.
Scroll Up
Scroll Down

Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,100+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!