Corporate Banner
Satellite Banner
Scientific Communities
Become a Member | Sign in
Home>Products>This Product

MaxDiscovery™ Human IL-17 ELISA Test Kit

Product Description
The MaxDiscovery™ Human IL-17 ELISA Test Kit is designed for quantitative determination of the concentration of human IL-17 in serum, plasma, and cell culture supernatant. Human interleukin 17 (IL-17) is a disulfide-linked homodimer with each ~ 17.5 kDa polypeptide of 136 amino acids (predicted mass = 17.5 kDa) after cleavage of a signal sequence of 19 amino acids. It contains six cysteines plus one potential N-linked glycosylation site, which is variably glycosylated, at least with recombinant proteins. It shares 63% and 58% sequence identity to those of mouse and rat, respectively and 72% identical to the thirteenth ORF of Herpesvirus saimiri. Originally identified as mouse cytotoxic T lymphocyte-associated antigen-8 (CTLA-8), IL-17 is produced by activated memory T lymphocytes. IL-17 appears to mediate communication between the immune system and the hematopoietic system. There is at least some species specificity for in vitro action on bone-marrow stromal cells. The IL-17 receptor (IL-17 R) from the mouse has been characterized. It is a 120 kDa type I transmembrane glycoprotein. There is neither an Ig-like domain nor the WSXWS motif of hematopoietin receptors in the 291 amino acid extracellular segment of the receptor, and there is no identifiable tyrosine kinase domain in the 521 residue cytosolic region. There are, however, serine-rich regions similar to those in IL-2 Rß, IL-4 R and G-CSF R. Thus, the receptor appears to be related to class I cytokine receptors. Based on cell line studies, IL-17 R is expressed by mast cells, fibroblasts, fetal hepatocytes, pre-B cells, and intestinal epithelial cells. It has been reported that IL-17 mediated T cell communication with the hematopoietic system. T cell-derived IL-17 induces fibroblasts to produce IL-6, IL-8, ICAM-1 and G-CSF, apparently by an NF-?B-mediated mechanism. IL-6 in turn promotes development of granulocyte/macrophage colonies, and G-CSF directs development of neutrophils. IL-17 also enhances proliferation of partially activated T cells and upregulates nitric oxide (NO) production in osteoarthritic cartilage. Selected Citations: Akhtar N., Verma, K. K., Sharma A. (Oct 2010) Study of pro- and anti-inflammatory cytokine profile in the patients with parthenium dermatitis Contact Dermatitis 63 (4): 203 – 208. Akhtar, N. et al (Dec 2010)Dysregulation of TH type cytokines in the patients of Parthenium induced contact dermatitis. Clinica Chimica Acta, 411 (23-24): 2024 - 2028.
Product MaxDiscovery™ Human IL-17 ELISA Test Kit
Company BIOO Scientific - Product Directory
Price Request a quote
More Information View company product page
Catalog Number 2124-01
Quantity 1 x 96 wells
Company Logo

BIOO Scientific - Product Directory
3913 Todd Lane Suite 312 Austin, TX 78744, USA

Tel: +1 512-707-8993
Fax: +1 512-707-8122

Scientific News
High Throughput Mass Spectrometry-Based Screening Assay Trends
Dr John Comley provides an insight into HT MS-based screening with a focus on future user requirements and preferences.
The MaxSignal Colistin ELISA Test Kit from Bioo Scientific
Kit can help prevent the antibiotic apocalypse by keeping last resort drugs out of the food supply.
"Good" Mozzie Virus Might Hold Key to Fighting Human Disease
Australian scientists have discovered a new virus carried by one of the country’s most common pest mosquitoes.
Non-Disease Proteins Kill Brain Cells
Scientists at the forefront of cutting-edge research into neurodegenerative diseases such as Alzheimer’s and Parkinson’s have shown that the mere presence of protein aggregates may be as important as their form and identity in inducing cell death in brain tissue.
Closing the Loop on an HIV Escape Mechanism
Research team finds that protein motions regulate virus infectivity.
New Class of RNA Tumor Suppressors Identified
Two short, “housekeeping” RNA molecules block cancer growth by binding to an important cancer-associated protein called KRAS. More than a quarter of all human cancers are missing these RNAs.
Potential Treatment for Life-Threatening Viral Infections Revealed
The findings point to new therapies for Dengue, West Nile and Ebola.
World’s First Therapeutic Venom Database
Open-source library describes nearly 43,000 effects on the human body.
Biologists Induce Flatworms to Grow Heads and Brains of Other Species
Findings shed light on role of a new kind of epigenetic signaling in evolution, could yield clues for understanding birth defects and regeneration.
Fat Cells Originating from Bone Marrow Found in Humans
Cells could contribute to diabetes, heart disease.
Scroll Up
Scroll Down

Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos