siMPLE™ siRNA Delivery Agent for Hard to Transfect Cell Lines is a nanoparticle siRNA transfection reagent that is composed of a proprietary peptide which facilitates cellular uptake of various molecular cargo (siRNA, oligonucleotides, peptides, fragments of DNA), with no toxic, non-specific effects. As an alternative to potentially toxic lipid based transfections, siMPLE™ siRNA Delivery Agent for Hard to Transfect Cell Lines, is particularly useful for primary, neuronal, differentiated and dendritic cells. The supplied delivery agent also works with common, easy to transfect cell lines. These peptides have an activated group which will bind to thiol functionalized siRNA, oligos, peptides or other complexes with free SH groups.
Food Triggers Creation of Regulatory T Cells IBS researchers document how normal diet establishes immune tolerance conditions in the small intestine.Light Signals from Living Cells Fluorescent protein markers delivered under high pressure.Counting Cancer-busting Oxygen Molecules Researchers from the Centre for Nanoscale BioPhotonics (CNBP), an Australian Research Centre of Excellence, have shown that nanoparticles used in combination with X-rays, are a viable method for killing cancer cells deep within the living body.Therapeutic Approach Gives Hope for Multiple Myeloma A new therapeutic approach tested by a team from Maisonneuve-Rosemont Hospital (CIUSSS-EST, Montreal) and the University of Montreal gives promising results for the treatment of multiple myeloma, a cancer of the bone marrow currently considered incurable with conventional chemotherapy and for which the average life expectancy is about 6 or 7 years.Cellular 'Relief Valve' A team led by scientists at The Scripps Research Institute (TSRI) has solved a long-standing mystery in cell biology by showing essentially how a key “relief-valve” in cells does its job.Genomic Signature Shared by Five Types of Cancer National Institutes of Health researchers have identified a striking signature in tumor DNA that occurs in five different types of cancer. Protein Protects Against Flu in Mice The engineered molecule doesn’t provoke inflammation and may hail a new class of antivirals.Cat Stem Cell Therapy Gives Humans Hope By the time Bob the cat came to the UC Davis veterinary hospital, he had used up most of his nine lives. Crowdfunding the Fight Against Cancer From budding social causes to groundbreaking businesses to the next big band, crowdfunding has helped connect countless worthy projects with like-minded people willing to support their efforts, even in small ways. But could crowdfunding help fight cancer?
Switch Lets Salmonella Fight, Evade Immune System Researchers at the University of Illinois at Chicago have discovered a molecular regulator that allows salmonella bacteria to switch from actively causing disease to lurking in a chronic but asymptomatic state called a biofilm.