The Viscosizer 200 is an innovation in automated viscosity measurement and molecular sizing using very small sample volumes. This new technology is driven by UV area imaging, and at its heart is a unique dual-pass capillary system, with two detection windows removing any injection time error. This instrument is ideally placed to serve those working within biopharmaceutical preformulation and formulation development, who need rapid viscosity information on a large number of low volume samples, in order to assess candidate developability.
The Viscosizer 200 is a new and unique viscosity and size analysis system which is capable of accurate, reproducible measurement of viscosity in sample volumes as low as 10µL. It can also perform a separate size analysis of particles in sample volumes as low as 10nL.
This is a dual-pass microcapillary-based instrument, supplied by a carousel autosampler which allows automated, high throughput sample delivery. It differs from other capillary-based viscometers in that it has two windows burned into the capillary, at each of which UV area imaging of absorbance in the sample takes place. Both size and viscosity analyses are based on time-based changes which occur between the two windows, eliminating the error associated with imprecision in sample injection time in other capillary-based viscometers.
The Viscosizer 200 is adaptable to a wide variety of uses, but is particularly well-positioned to assist in preformulation studies, where sample numbers are high but volumes are very low. It can rapidly provide vital information on the viscosities of a range of formulations at a much earlier stage than previously possible, enabling quick detection of potentially problematic samples and dramatically reducing risk on investment in development.
The system also enables sizing of UV-active molecules present within complex formulations or matrices, lending itself to a range of applications, including the measurement of proteins and small molecules within excipient-laden formulations.
Accurate, automated measurement of viscosity in the range 0.9 cP to 120 cP by UV Area Imaging. Sample volume of less than 10 µL required for viscosity analysis. Precise mass-weighted hydrodynamic sizing of selected particles in the range 0.2 nm to 100 nm radius by Taylor Dispersion Analysis. Sample volume of less than 10 nL required for sizing. Rapid batch analysis using the 45-position carousel autosampler. Sizing of UV-active particles can be performed even within complex formulations. Enclosed microcapillary geometry free of interfacial effects. Highly reproducible results. Wide range of working concentrations. User-selectable incident light wavelength. Intuitive and flexible Malvern software package.