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Sirius inForm

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The more that formulators can learn in the chemistry lab, the better they can design formulations that will deliver the desired performance. Whether it’s controlled release, solubility enhancement or precipitation inhibition that’s required, the novel assays in Sirius inForm will show how drugs behave under a wide range of conditions. It’s a powerful tool to investigate ionisation, solubility, supersaturation, dissolution and lipolysis.
Automation and precision ensure high quality data, with temperature and pH under constant control and biorelevant conditions established using SIFs, SLFs or SGFs. Please see our Application Note range for more information.
Dissolution: Biorelevant, biphasic, automated
Sirius inForm bridges the gap between research-based micro-scale dissolution and the compendial world. Innovative methods such as biphasic dissolution and gradient pH adjustments show how a drug would behave under biorelevant conditions. Automation and precision engineering ensure that dissolution experiments are accurate and highly reproducible.
Solubility, controlled supersaturation, precipitation
With many new drugs now requiring solubility enhancement, formulators need ways to characterize supersaturation and precipitation. Sirius inForm measures solubility using the CheqSol method; new assays report the extent and duration of supersaturation, precipitation rates and excipient gain factors. Uniquely, concentrations are calculated from measured pH, which eliminates interference by suspended solids. There is also a UV option for controlled supersaturation studies.
A versatile platform
Sirius inForm is a versatile platform for automated analysis of solutions. It provides temperature control and high quality stirring, pH measurement and control, ability to add sample  and reagents automatically, in-situ UV measurement and the ability to remove aliquots of sample for off-line analysis. Lipolysis assays to study digestion of lipid-based formulations are supported. UV enhancements include multi-component sensing, and Tyndall Rayleigh scattering correction to reduce the effect of suspended solids during dissolution studies.

Product Sirius inForm
Company Sirius Analytical Instruments Ltd
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Sirius Analytical Instruments Ltd
Forest Row Business Park, Station Road, Forest Row, East Sussex. RH18 5DW

Tel: +44 (0) 1342 820720
Fax: +44 (0) 1342 820725

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