Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

EPA Awards $27 Million Contract to Expression Analaysis

Published: Thursday, August 09, 2012
Last Updated: Thursday, August 09, 2012
Bookmark and Share
Renewed contract for expansion of ToxCast's genomic data.

The Environmental Protection Agency's (EPA) ToxCast™ Program, launched to forecast the toxicity of chemical compounds for humans and the environment, is expanding genomic data collection through a renewed five-year contract with Expression Analysis (EA), which will serve as the program's primary contractor for RNA biomarker analysis.

The $27 million contract calls for EA to investigate toxicology-related RNA biomarkers for up to 12,100 compounds in 121,100 biological samples using high-throughput PCR assays, gene expression microarrays, and transcriptome sequencing. EA will perform bioinformatic and statistical analyses to ensure the end-point data incorporated into the ToxCast database accurately represent the biology of the sample and are not subject to assay artifacts or batch-related effects.

"Our role is to provide reproducible end-point data for the EPA's toxicologists who are the primary investigators for ToxCast. The integrity of genomic data for this long-term study is crucial. ToxCast has the potential to greatly enhance the EPA's ability to predict the toxicity of various chemicals as well as prioritize the chemicals for rigorous toxicity testing," says Wendell Jones, Ph.D., Vice President of Bioinformatics and Statistics at EA.

All work will be conducted in EA's GLP-compliant, CLIA-certified laboratories under rigorous quality control standards. As structured in the previous contract, the EPA will review detailed Standard Operating Protocols for every assay performed and audit EA's facilities at the discretion of the Director of Quality Assurance at the National Center for Computational Toxicology.

Existing ToxCast initiatives have profiled approximately 2,000 chemicals from a broad range of sources, including industrial and consumer products, pesticides, food additives, products advertised as "green," nanomaterials and drugs not placed on the market.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,700+ scientific posters on ePosters
  • More than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Expression Analysis Announces a GWAS Data Analysis and Resequencing Grant
Expression Analysis, the industry’s leading provider of genomic services for clinical trials and research, announces they will award a Genome Wide Association Study (GWAS) Data Analysis and Resequencing Grant.
Thursday, October 02, 2008
Expression Analysis Awarded EPA Contract for ToxCast™ Genomic Services
Expression Analysis will provide gene expression and genotyping services for EPA's ToxCast™ Program.
Friday, April 13, 2007
Scientific News
New Virus Identified In Blood Supply
Scientists have discovered a new virus that can be transmitted through the blood supply.
Tracking Changes in DNA Methylation In Real Time At Single-Cell Resolution
Whitehead Institute researchers have developed a methodology to monitor changes in DNA methylation over time in individual cells.
DNA Alterations as Among Earliest to Occur in Lung Cancer Development
Genetic footprints of precancer detectable in some blood samples.
Bar-Coding Technique Opens Up Studies Within Single Cells
Scientists have developed a method for simultaneously imaging and identifying dozens of molecules within individual cells.
Scientists Learn How to Predict Plant Size
VIB and UGent scientists have developed a new method which allows them to predict the final size of a plant while it is still a seedling.
New Device Reduces Time to Diagnose Infections
A new diagnostic device created by a collaborative team of UA engineers and scientists may significantly reduce the amount of time necessary to diagnose tissue infections.
Surprising Mechanism Behind Antibiotic-Resistant Bacteria Uncovered
Now, scientists at TSRI have discovered that the important human pathogen Staphylococcus aureus, develops resistance to this drug by “switching on” a previously uncharacterized set of genes.
Researchers Develop qPCR Prognosis Test for NSCLC Patients
A nine-gene molecular prognostic index (MPI) for patients with early-stage non-small cell lung cancer (NSCLC) was able to provide accurate survival stratification and could potentially inform the use of adjuvant therapy in patients struggling with the disease.
Genome Wide Annotation of Primary miRNAs Reveals Novel Mechanisms
Researchers have devised a strategy for genome-wide annotation of primary miRNA transcripts, providing extensive new annotations in human and mouse, and shedding light on mechanisms of regulation of microRNA gene expression.
‘Fishing Expedition’ Nets Nearly Tenfold Increase in Number of Sequenced Virus Genomes
Newly developed computational tool finds 12,500 genomes of viruses that infect microbes.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,700+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos