Corporate Banner
Satellite Banner
qPCR
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Tom Maniatis: A Deep Sense that Science Must Be Shared

Published: Tuesday, September 11, 2012
Last Updated: Tuesday, September 11, 2012
Bookmark and Share
History books are filled with the technical advances that made genetic engineering possible, from the discovery of enzymes that cut and paste DNA to the development of techniques for reading the sequence of genes.

But perhaps more than any other advance in molecular biology, it was a centuries-old technology – ink on paper, in the form of Tom Maniatis’ 1982 Molecular Cloning manual – that was responsible for igniting the revolution of recombinant DNA.

The manual – often referred to as “the Bible” by students and researchers — contained practically every technique biologists needed to know in order to manipulate DNA. With these techniques scientists could identify genes that cause disease and they could produce new drugs such as human insulin. Later, the techniques proved indispensable for the success of the Human Genome Project. Maniatis’ laboratory developed many of the techniques in the manual, and they were so clearly explained that complete novices to molecular biology could pick up the manual and get instant results.

“It’s impossible to overstate the impact this manual had on a rapidly expanding field,” wrote the publisher on the manual’s 25th anniversary. “Molecular Cloning was the book that really put the techniques in every lab’s hands. It opened a door for many researchers into the world of recombinant DNA technology and played a significant role in spreading these approaches through the scientific community.”

Maniatis, now the chairman of the Department of Biochemistry and Molecular Biophysics and Isidore S. Edelman Professor of Biochemistry, still seems surprised at the impact the manual has had around the world.

“I got an email the other day from Huda Zoghbi, who discovered the gene that causes a severe form of autism in young women [Rett Syndrome],” he said. “It’s amazing to me. Here’s this powerhouse researcher, a member of the National Academy of Sciences and a Howard Hughes investigator, who said she knew nothing about recombinant DNA when she got her first research position. But she told me she used the manual to write her first NIH grant (which was awarded).”


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
New Method Promises to Speed Development of Food Crops
A new study addresses a central challenge of transgenic plant development: how to reliably evaluate whether genetic material has been successfully introduced.
Study Validates Analysis of Copy Number Variation in Miniaturized Reaction Volumes
Data shows that accurate and reproducible CNV results can be produced with IntelliQube using the Array Tape® consumable.
Faster Drug Discovery?
Startup develops more cost-effective test for assessing how cells respond to chemicals.
Edited Stem Cells Offer Hope of Precision Therapy for Blindness
Findings raise the possibility of treating blinding eye diseases using a patient's own corrected cells as replacement tissue.
Parallel Single-Cell Profiling
New single-cell genomics protocol allows researchers to study links between DNA modifications (methylation) and the activity of a gene.
Pathogens Found in Iceman's Gut
Scientists discover Helicobacter pylori in the contents of Ötzi’s stomach along with some unexpected insights into the coexistence of man and bacterium.
Diagnosing Cancer from a Single Drop of Blood
What if a physician could effectively diagnose cancer from one drop of a patient’s blood?
Tracing a Cellular Family Tree
New technique allows tracking of gene expression over generations of cells as they specialize.
Accelerating Protein Evolution
A new tool enables researchers to test millions of mutated proteins in a matter of hours or days, speeding the search for new medicines, industrial enzymes and biosensors.
Ancient Viral Molecules Essential for Human Development
Genetic material from ancient viral infections is critical to human development, according to researchers at the Stanford University School of Medicine.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!