Corporate Banner
Satellite Banner
qPCR
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Seegene Announces the World’s First Real-time PCR Technology

Published: Tuesday, May 13, 2014
Last Updated: Tuesday, May 13, 2014
Bookmark and Share
New “MDisc” technology breathes new life into real-time PCR by overcoming the challenge of “one channel, one Ct”.

Seegene Inc. has announced “MDisc”, the industry's first simultaneous multi-quantification real-time PCR technology that will help ignite a paradigm shift in the PCR market.

Real-time PCR is a gold standard in molecular diagnostics because of its versatility, speed and ease of use. However, few advances in real-time PCR chemistry have been made over the past 20-years despite the growing demand for assays that deliver both high multiplexing and quantification of targets.

In order to detect more than two target genes in a single fluorescent channel, the current real-time PCR technologies must use melt curve analysis after amplification. The limitations of current melt curve-based technologies include end point analysis after a PCR step leads to longer total around time, quantification analysis is impracticable with end-point analysis, target sequence variations on probe binding region likely leads to melt temperature(Tm) variations.

MDisc transforms real-time -PCR into a vastly more powerful technology capable of simultaneous amplification and detection of multiple target genes in a single channel without melt curve analysis. This multi-quantification capability will enable clinicians to gain a complete package of diagnostic information including the diagnosis of disease, degree of disease progression and severity, and monitoring of treatment.

Additional MDisc technology benefits include

• Multi-Ct(threshold cycle) values in a single channel for the multi target detection.
• SNP genotyping in a single channel such as homozygous wild type or mutant, or heterozygous samples without melt curve analysis.
• Multiple channels not necessary for multiplex target detection or quantification; more economical approach for gene analysis.
• No more crosstalk between channels by selecting channels distanced from each other.
• Freedom from well-to-well and instrument-to-instrument variations.
• Ability to select fluorescent dyes regardless of real-time PCR instrument type. (Up to now, the optical filter sets are designed to maximize fluorescence detection only for specific dyes in specific channels.)

“MDisc is the world’s very first technology for multi Ct in a single channel and opens a new chapter for PCR-based research applications and molecular diagnostics," said Dr. Chun, Jong-Yoon, Founder, CTO and CEO of Seegene. “The accurate measurement of both the amount and the number of different pathogens present is required for diagnosis, prognosis and prediction of disease. Adding the power of simultaneous multi-quantification to real-time PCR will deliver a more comprehensive and actionable diagnosis for improved patient care, and reduced healthcare costs.”

Dr. Chun added, "With MDisc, real-time PCR instruments will no longer require multiple channels, making it an economically viable technology for high volume gene analysis.”


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Seegene and Eidia Collaborate
Through this agreement, Eidia gains access to Seegene's portfolio of TOCE™ technology-based multiplexed molecular diagnostic tests for the Japanese diagnostic test market.
Tuesday, July 09, 2013
Seegene and DuPont Sign Agreement for Food Safety Testing
The agreement will see the companies jointly develop highly multiplexed assays to detect foodborne pathogens.
Friday, May 25, 2012
Seegene Introduces Test to Simultaneously Detect 18 Different Human Papillomaviruses
The Seeplex® 18-plex Test is performed with one multiplex PCR in a single tube and capillary electrophoresis for automated detection of HPVs.
Thursday, July 12, 2007
Scientific News
Surprising Mechanism Behind Antibiotic-Resistant Bacteria Uncovered
Now, scientists at TSRI have discovered that the important human pathogen Staphylococcus aureus, develops resistance to this drug by “switching on” a previously uncharacterized set of genes.
Researchers Develop qPCR Prognosis Test for NSCLC Patients
A nine-gene molecular prognostic index (MPI) for patients with early-stage non-small cell lung cancer (NSCLC) was able to provide accurate survival stratification and could potentially inform the use of adjuvant therapy in patients struggling with the disease.
Genome Wide Annotation of Primary miRNAs Reveals Novel Mechanisms
Researchers have devised a strategy for genome-wide annotation of primary miRNA transcripts, providing extensive new annotations in human and mouse, and shedding light on mechanisms of regulation of microRNA gene expression.
‘Fishing Expedition’ Nets Nearly Tenfold Increase in Number of Sequenced Virus Genomes
Newly developed computational tool finds 12,500 genomes of viruses that infect microbes.
First Gene that Causes Mitral Valve Prolapse Identified
An international research collaboration led by MGH investigators has identified the first gene in which mutations cause the common form of mitral valve prolapse, a heart valve disorder that affects almost 2.5 percent of the population.
Automation Abound at AACC in Atlanta
Discover the latest breakthroughs, trends and products from the AACC Annual Meeting & Clinical Lab Expo.
Ultrafast DNA Diagnostics
New technology developed by UC Berkeley bioengineers promises to make a workhorse lab tool cheaper, more portable and many times faster by accelerating the heating and cooling of genetic samples with the switch of a light.
The Genetic Roots of Adolescent Scoliosis
Scientists at the RIKEN Center for Integrative Medical Sciences in collaboration with Keio University in Japan have discovered a gene that is linked to susceptibility of Scoliosis.
Diagnostic Test Developed for Enterovirus D68
researchers at Washington University School of Medicine in St. Louis have developed a diagnostic test to quickly detect enterovirus D68 (EV-D68), a respiratory virus that caused unusually severe illness in children last year.
Simple Technology Makes CRISPR Gene Editing Cheaper
University of California, Berkeley, researchers have discovered a much cheaper and easier way to target a hot new gene editing tool, CRISPR-Cas9, to cut or label DNA.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!