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Evaluation of a Novel Approach for the Measurement of RNA Quality
Timothy Wilkes; Alison Devonshire; Carole Foy

The potential medical applications of microarrays have generated much interest, within the biomedical community. Numerous potential sources of variation have raised concerns regarding assay consistency and data quality. Previous studies have highlighted RNA integrity as having a major effect on data quality. We describe here a comparison of the performance characteristics of the Agilent (Bioanalyser) and Lab901 (Screen Tape System) platforms, and their capacity to determine sample RNA integrity.

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Microfluidic PCR device for diagnostic pathogen detection
Johannes R. Peham, Hannes Steiner, Walter Grienauer, Rudolf Heer, Michael J. Vellekoop, Christa Nöhammer, Herbert Wiesinger

In this work a microfluidic cyclic flow PCR device is presented, which is capable of replicating the bacterial genomic DNA sequence of the 16S ribosomal RNA. The standard laboratory processing time of 3 h could be decreased to 60 min with the microfluidic reactor without loosing PCR efficiency. Integrating an optical fluorescence detector for dsDNA measurement would evolve this device into a micro total analysis system.

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Differential metabolic response of tomato hybrids to herbivory
Raghava T, Puja Ravikumar, Rajendra Hegde, Anil Kush

In this study we have documented the HIPVs produced by different plant organs in three agronomically important Lycopersicon esculentem (tomato) cultivars in the event of herbivory. The nocturnal and diurnal feeding of third instar Spodoptera littura larvae induces characteristic VOCs mainly terpenes, in all the three hybrids viz., All Rounder, Shaktiman and Lakshmi.

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Design and Fabrication of a Micro PCR Module for POC Applications
E. Morganti, C. Collini, C. Ress, A. Adami, L. Lorenzelli

The design and fabrication process of a micro PCR module is presented. The final system will be integrated in an innovative Lab on a Chip (LOC) to provide a technological platform able to detect autoimmune genetic diseases.

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A Web Interface for Automatic Microarray Analysis
Enrico Glaab, Jonathan M. Garibaldi, Natalio Krasnogor

DNA-Microarray technology provides a diagnostic tool for studying cancer and genetic diseases, allowing the experimenter to identify disease related genes and predict the tumour type for new cell samples. However, the statistical analysis of microarray data is a time-consuming and error-prone process. To address this problem we have developed a web interface for automatic DNA-microarray analysis, ArrayMining.net, which guides the user through the analysis process and performs automatic parameter

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A modular and stochastic approach to the study of gene circuits using P systems
Romero-Campero FJ, Blakes J, Cao H, Camara M, Krasnogor N.

presented at Genomes to Systems Manchester, UK March 17-19 2008

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Formal informatics and machine learning for more principled systems and synthetic biology
Romero-Campero FJ, Blakes J, Camara M, Willams P, Perez-Jimenez MJ, Krasnogor N

presented at European Conference on Synthetic Biology (ESF-UB Conference in Biomedicine), Sant Feliu de Guixols, Spain, 24-29 November 2007.

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A systems analysis of the AHL Quorum Sensing system in Pseudomonas aeruginosa
Romero-Campero FJ, Blakes J, Camara M, Krasnogor N.

presented at Systems Biology (ESF-UB Conference in Biomedicine), Sant Feliu de Guixols, Spain, 12-17 April 2008

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An Integrated Development Environment for Synthetic Biology Models
Blakes J, Romero-Campero FJ, Twycross J, Cao H, Krasnogor N

presented at European Conference on Synthetic Biology (ECSB) II: Design, Programming and Optimisation of Biological Systems (ESF-UB Conference in Biomedicine), Sant Feliu de Guixols, Spain, 29 March - 03 April 2009

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Showing Results 51 - 60 of 95
Scientific News
Profiling DNA Viruses in Arctic Lakes
The Arctic's freshwater lakes contain viral communities composed of DNA viruses from lineages that are largely distinct from those described elsewhere, a new study suggests.
Polar Distribution of MicroRNAs Discovered within Eukaryotic Cells
A plausible new mechanism contributing to asymmetric cell division.
A New Role for Zebrafish: Larger Scale Gene Function Studies
A relatively new method of targeting specific DNA sequences in zebrafish could dramatically accelerate the discovery of gene function and the identification of disease genes in humans.
Rapid Determination of the Chromosomal Phase of Genetic Variants
Researchers have developed a rapid, scalable, and cost-effective method for chromosomal phasing that provides researchers with a new method to determine if genetic variants are linked on the same chromosome.
Seeing the Action
Researchers have developed a way to observe both the forces present and the behavior that occurs during cell hemifusion; the merging of the lipid bi-layers of two cells.
From Worker to Queen at the Drop of a Gene
Biologists have found that the hierarchical fate of one of nature's most important pollinators comes down to which genes are "turned on or off".
Faster, Portable Microbial analysis
New miniaturized microbial analysis machine permits the detection of microbes in water, soil and the upper atmosphere.
Genetic Markers for Detecting and Treating Ovarian Cancer
Custom bioinformatics algorithm identifies human mRNAs that distinguish ovarian cancer cells from normal cells and provide new therapeutic targets
Single-cell Analysis Hits its Stride
Advances in technology and computational analysis enable scale and affordability, paving the way for translational studies.
New Genomic Research Amends Earlier Triple Negative Breast Cancer Finding
Previously reported molecular finding unable to be validated.
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