Corporate Banner
Satellite Banner
Scientific Communities
Become a Member | Sign in
Home>Resources>Application Notes>This Application Note
  Application Notes
Scientific News
Integrated Omics Analysis
Studying multi-omics promises to give a more holistic picture of the organism and its place in its ecosystem, however despite the complexities involved those within the field are optimistic.
Unravelling the Role of Key Genes and DNA Methylation in Blood Cell Malignancies
Researchers from the University of Nebraska Medical Center have demonstrated the role of Dnmt3a in safeguarding normal haematopoiesis.
Salford Lung Study - The First Real World Clinical Trial
In this podcast, we learn about the Salford Lung Study and its potential to revolutionize the way we assess new drugs and treatments around the world.
Point of Care Diagnostics - A Cautious Revolution
Advances in molecular biology, coupled with the miniaturization and improved sensitivity of assays and devices in general, have enabled a new wave of point-of-care (POC) or “bedside” diagnostics.
Smart Gloves Monitor Parkinson’s Disease
URI biomedical engineering professor creating smart gloves to monitor parkinson’s disease patients.
Zika Virus Infection Alters Human and Viral RNA
Researchers have discovered that Zika infections results in human and viral genetic modification.
Cell Metabolism Linked to Spread of Cancer
Scientists discover macrophage metabolism can be attuned to prevent the spread of cancer.
First Entirely 3D-printed Organ-on-a-Chip with Integrated Sensors
New approach to manufacturing may allow researchers to rapidly design organs-on-chips that match the properties of a specific disease or individual patient's cells.
Nanoparticles Offer Promising Platform for Flavivirus Treatment
New nanoparticle effectively vaccinated mice against one dengue strain and could be created to target all four.
Advances in Alzheimer’s Research
Researchers show how a diseased vertebrate brain can naturally react to Alzheimer’s pathology by forming more neurons.
Scroll Up
Scroll Down

mosquito® Crystal for the rapid screening and optimisation of crystallisation conditions of the bacterial periplasmic binding protein, HbpA
Bookmark and Share

TTP LabTech

Recently, Vergauwen and colleagues identified a bacterial periplasmic lipoprotein in H. influenzaeRd, a global human pathogen that specifically binds both reduced glutathione (GSH) and oxidised glutathione (GSSG) with physiologically relevant affinity.

This discovery came as a complete surprise as this protein was previously thought to be a heme-binding protein A (HbpA) serving as a binding platform for heme. Vergauwen and colleagues employed a combination of structural, biochemical and cellular studies in establishing the physiological role of this protein, as a periplasmic binding protein that primes glutathione import via its cognate ABC-like dipeptide transporter DppBCDF.

This application note describes the use of mosquito® Crystal to screen and optimise crystallisation conditions for GbpA using limited amounts of protein, thus highlighting its ability to address complex biological questions in structural biology quickly and efficiently.

Further Information

Related Content

David Newble Joins TTP Labtech as New Managing Director
Recent appointment promises to drive innovation strategy and further strengthen R&D pipeline
Thursday, June 18, 2015
TTP Labtech and Almac Group’s Form Strategic Alliance
Alliance consolidates fluorescence lifetime technology to form a one-stop shop for compound screening.
Thursday, February 05, 2015
Innovative Technology Enables First Crystal Structure of mGlu5 Transmembrane Domain to be Determined
Several novel drug candidates have been identified to help treat specific neuropsychiatric disorders.
Saturday, July 19, 2014
TTP Labtech Revenues up 43%
The company has reported an impressive 43% increase in revenues and an associated increase in profits over 2013.
Monday, June 23, 2014
TTP Labtech Acquires Assets from AssayMetrics
Significant improvements in assay reagents and availability of HTS-compatible readers has propelled fluorescence lifetime technology to the vanguard of cost-effective screening technologies.
Thursday, January 09, 2014
Major Protein Structure Discovery Achieved Using TTP Labtech’s Mosquito LCP
Researchers have successfully reported the structure of a Class B G-Protein Coupled Receptor (GPCR) using lipidic cubic phase (LCP) protein crystallisation.
Friday, July 26, 2013
TTP Labtech Announces On-Going Growth
An investment of £3.8M in global R&D sees product sales grow over 20%.
Thursday, July 11, 2013
TTP Labtech will Showcase its Latest Automated Technology Innovations in Europe
Delivering a wealth of new products to the attendees of ELA 2012.
Monday, May 21, 2012
TTP Labtech Announces Company Growth
New product offering demonstrates strong commitment to product development.
Friday, May 11, 2012
TTP LabTech Presents Protein Crystallography Community with News Service
TTP LabTech has launched the 2011 issue of its LabCrystal magazine, designed specifically for scientists who perform protein crystallography.
Monday, December 19, 2011
Webinar Places Spotlight on Mosquito Applications
Leading speakers discuss hot topics for TTP LabTech’s mosquito Crystal and mosquito LCP.
Tuesday, September 13, 2011
The Rapid Screening and Optimisation of Crystallisation Conditions of the Bacterial Periplasmic Binding Protein, HbpA and the Elucidation of its Role as a Glutathione Import Protein
A recent study reported in PNAS employed TTP LabTech’s mosquito® crystal for the identification of a bacterial periplasmic lipoprotein in H. influenzae Rd.
Monday, September 12, 2011
Driving the Science of the Future
TTP LabTech announce that they are founding sponsors of the inaugural European Lab Automation (ELA) conference and exhibition, to be held at the Conference Centre Hamburg (CCH), Hamburg, Germany, from the 30th June-1st July.
Friday, May 20, 2011
TTP LabTech to Demonstrate New mosquito® LCP at ACA, Chicago
Dedicated solution to increase throughput of lipid cubic phase screening
Wednesday, July 07, 2010
Increased Demand Drives Queensland Compound Library Expansion
QCL capacity is increased by the acquisition of a fourth additional comPOUND® storage module.
Thursday, June 10, 2010
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,200+ scientific videos