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A Fluorescence Based Assay of the Epigenetic Enzyme Histonedeacetylase 1 (HDAC1)
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BMG LABTECH

Inhibition of HDACs results in histone overacetylation that in turn can lead to a controlled cell death (apoptosis). Several HDAC inhibitors (HDIs) are in phase I or II clinical trials. In the last years, research focused on the development of selective HDIs. To determine the inhibitory effect fluorogenic assays with recombinant proteins could offer a valuable performance.

This application note details how the POLARstar OPTIMA fluorescence microplate reader was used to determine the inhibitor effect of SAHA against HDAC1.

Further Information

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