Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>Resources>Application Notes>This Application Note
  Application Notes
Scientific News
Big Genetics in BC: The American Society for Human Genetics 2016 Meeting
Themes at this year's meeting ranged from the verification, validation, and sharing of data, to the translation of laboratory findings into actionable clinical results.
Stem Cells in Drug Discovery
Potential Source of Unlimited Human Test Cells, but Roadblocks Remain.
Automated Low Volume Dispensing Trends
Gain a better understanding of the current and future market requirements for fully automated LVD systems.
Personality Traits, Psychiatric Disorders Linked to Specific Genomic Locations
Researchers have unearthed genetic correlations between personality traits and psychiatric disorders.
Forensic 3D Documentation of Skin Injuries
In this study, the validity of using photogrammetry for documenting injuries in a pathological context was demonstrated.
3-D Printed Dog’s Nose Improves Vapor Detection
By mimicking how dogs get their whiffs, a team of government and university researchers have demonstrated that “active sniffing” can improve by more than 10 times the performance of current technologies that rely on continuous suction to detect trace amounts of explosives and other contraband.
New Markers for Forensic Body-fluid Identification
University of Bonn researchers have successfully identified specific Micro-RNA signatures to help forensically identify body fluids.
Genetics Control Regenerative Properties Of Stem Cells
Researchers define how genetic factors control regenerative properties of blood-forming stem cells.
Major Neuroscience Initiative Launched
Tianqiao and Chrissy Chen Institute invest $115 million to further expand neuroscience research, while Caltech construct $200 million biosciences complex.
Making It Personal
Cancer vaccine linked to increased immune response against leukemia cells.
Scroll Up
Scroll Down

Analysis of a New High Throughput Screening Detection Technology for Rapid hERG Safety Testing using a Fluorescence Polarization Assay
Bookmark and Share


Biotek Instruments

Background
Speed and sensitivity are the hallmarks of Fluorescence Polarization (FP) assay technologies. Due to this FP has seen penetration in the drug discovery and drug development markets for High Throughput Screening applications. For a good overview of applications/target audiences for FP here is an easy to read and interesting White Paper with good citations for further reading: Fluorescence Polarization in Life Sciences. The Predictor hERG biochemical FP assay has been used as a model of FP performance validation used on our Synergy lines, not only because it is an assay designed for HTS run at low volume in 384-well plates, but because quantification of hERG channel binding and inhibition are cardio toxicity tests recommended for all drug compounds before human use (e.g. in pre-clinical trials). Therefore, the assay needs to prove it can compare with GLP-compliant gold standard methods, and the detection technology used to produce that data must be rigorous enough to do the same. Although BioTek has published a number of pieces of marketing collateral using the Predictor hERG assay, until Synergy Neo, other Synergy models could only provide sensitivity acceptable for detection of this assay at the cost of speed. Publication of optimal read parameters was either largely ignored or minimized in the other BioTek collateral for this reason, as the combination of assay and detection parameters required for optimal data were largely prohibitory for HTS applications when competitors could do it at ~ 2 min plate read time within a 2 hour assay incubation window.

Further Information

Related Content

BioTek Introduces New General Manager in Germany
Company appoints Dr. Frank Siefert who will be responsible for managing day-to-day operations in Germany.
Tuesday, November 03, 2015
BioTek to Exhibit at Neuroscience 2015
Join BioTek Instruments as they demonstrate the latest microplate innovations at the SfN’s 45th annual meeting. Neuroscience 2015 will be held October 17-21 at McCormick Place in Chicago, IL. BioTek will showcase their products at booth #1809.
Tuesday, September 29, 2015
BioTek Readers Receive BellBrook Certifications
Company’s multi-mode microplate readers earn Transcreener HTS Assay certifications.
Friday, September 11, 2015
BioTek Readers Receive Promega DLReady™ Certification
Promega’s Dual-Luciferase© Reporter System demonstrate both companies’ common commitment.
Friday, August 07, 2015
BioTek Instruments Receives 5x5x5 Growth Award for Technology
BioTek Instruments has been recognized as one of the 5x5x5 Growth Award winners for 2015.
Wednesday, July 29, 2015
BioTek Expands in the United Kingdom
Company expands their ongoing investment with the opening of their new UK Office in Swindon.
Friday, June 05, 2015
Biotek Named as Finalist for Top Employer Award
The company have been announced as a finalist for the Secretary of Defense Employer Support Freedom Award.
Thursday, May 21, 2015
BioTek Nominated for Department of Defense’s Top Employer Award
BioTek Instruments been nominated for the 2015 Secretary of Defense Employer Support Freedom Award by the Employer Support of the Guard and Reserve (ESGR), a Department of Defense (DoD) office.
Tuesday, March 31, 2015
BioTek Receives 2014 Supplier of the Year Award from Fisher Scientific
BioTek was presented with the award at Thermo Fisher Scientific’s annual meeting in Phoenix.
Wednesday, March 25, 2015
BioTek to Receive 2014 Governor’s Excellence in Worksite Wellness Award
Award recognises worksites in Vermont that promote the health and wellness of their employees.
Wednesday, January 21, 2015
BioTek Receives Two Awards from ESGR
Company has received the Patriot Award and the Above and Beyond Award.
Friday, August 22, 2014
BioTek Receives Extraordinary New Product Line Award from Fisher
Company receives award for Cytation 3 Cell Imaging Multi-Mode Reader.
Tuesday, March 04, 2014
BioTek Announces Establishment of Japanese Office
BioTek Japan will be fully functional by July 1, 2013.
Monday, June 10, 2013
BioTek Responds to Growing AP Market Needs with New Taiwan Office
New office will focus on increasing BioTek's brand presence in Taiwan.
Tuesday, May 14, 2013
BioTek Wins Governor's Award for Outstanding Workplace Safety
BioTek receives the award by Governor Peter Shumlin at the 9th Annual Vermont Workplace Safety Conference.
Thursday, April 18, 2013
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
4,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,300+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!