Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>Resources>Application Notes>This Application Note
  Application Notes
Scientific News
Big Genetics in BC: The American Society for Human Genetics 2016 Meeting
Themes at this year's meeting ranged from the verification, validation, and sharing of data, to the translation of laboratory findings into actionable clinical results.
Stem Cells in Drug Discovery
Potential Source of Unlimited Human Test Cells, but Roadblocks Remain.
Cancer Genetics: Key to Diagnosis, Therapy
When applied judiciously, cancer genetics directs caregivers to the right drug at the right time, while sparing patients of unnecessary or harmful treatments.
BGI Sequences Gingko Tree, Revealing Large, Highly Repetitive Genome
Researchers at BGI have sequenced the more than 10-gigabase ginkgo genome to find a high number of repetitive sequences as well as a number of gene clusters that appear to be involved in defense mechanisms.
Survey of New York City Soil Uncovers Medicine-Making Microbes
Microbes have long been an invaluable source of new drugs. And to find more, we may have to look no further than the ground beneath our feet.
Accelerating the Detection of Foodborne Bacterial Outbreaks
The speed of diagnosis of foodborne bacterial outbreaks could be improved by a new technique developed by researchers at the Georgia Institute of Technology.
Making Personalized Medicine a Reality
Groundbreaking technique developed at McMaster University is helping to pave the way for advances in personalized medicine.
Scientists Identify Unique Genomic Features in Testicular Cancer
The findings may shed light on factors in other cancers that influence their sensitivity to chemotherapy.
Top 10 Life Science Innovations of 2016
2016 has seen the release of some truly innovative products. To help you digest these developments, The Scientist have listed their top picks for the year.
BioCision Forms MedCision
The new company will focus on technologies for the management and automation of vital clinical processes.
Scroll Up
Scroll Down

A Complete Forensic Toxicology Screening Procedure for Drugs and Toxic Compounds in Urine and Plasma Using LC-MS/MS
Bookmark and Share


Thermo Scientific

Introduction
Forensic toxicology laboratories commonly use automated immunoassays, gas chromatography-mass spectrometry (GC-MS) and high pressure liquid chromatography-diode array detector (HPLC-DAD) techniques to perform toxicology screening analyses. None of these techniques are able to identify all the drugs and toxic compounds that are potentially present in a sample. Implementation of liquid chromatography-mass spectrometry (LC-MS) for forensic toxicology screening provides specific and sensitive analysis of drugs and toxic substances. The benefits of the LC-MS/MS screening methodology include a simple sample preparation procedure, ease of adding new compounds to the screening method and fewer limitations based on compound volatility and thermal stability. In addition, Thermo Scientific ToxID automated toxicology screening software is able to automatically generate both Summary and Long Reports, avoiding the need for manual analysis of each sample chromatogram. This application note describes the use of the Thermo Scientific LXQ ion trap mass spectrometer equipped with an ESI source and HPLC for identification of unknown compounds in urine and plasma for clinical research and forensics.

Further Information

Related Content

Thermo to Acquire FEI Company
Leading electron microscopy platform complements mass spectrometry leadership to accelerate advancements in structural biology.
Tuesday, May 31, 2016
Advancing Lithium-Ion Battery Research
The increasing number of components in a lithium-ion battery makes it essential to use a variety of analytical methods to attain complete characterization.
Wednesday, October 28, 2015
Automating Deep Characterization of Biotherapeutic Proteins
Thermo's new PepFinder software streamlines relative and absolute quantitation, and identification of proteins from biological samples using LC-MS.
Thursday, June 19, 2014
Thermo Scientific Chromatography Columns/Consumables Catalog Goes Mobile
2014-15 Chromatography Columns and Consumables Catalog now available in print, pdf and interactive mobile versions.
Thursday, February 27, 2014
Thermo Collaborates with Leading EU and UK Pesticide Testing Labs
The company's Pesticide Analysis Center of Excellence provides technology, consultation and support.
Tuesday, November 19, 2013
Thermo Scientific at ASMS 2013
Learn how scientists and researchers are transforming science by applying innovative solutions to a wide range of qualitative and quantitative applications.
Monday, May 13, 2013
Thermo Fisher Scientific Reports First Quarter 2013 Results
Adjusted earnings per share grew 17% to a record $1.37 with revenue increased 4% to a first quarter record of $3.19 billion.
Thursday, April 25, 2013
Thermo Fisher Scientific to Acquire Life Technologies
Transaction expected to create an unrivaled leader in serving research, specialty diagnostics and applied markets.
Wednesday, April 17, 2013
Thermo Fisher Scientific to Acquire Life Technologies Corporation
The definitive agreement will see Thermo Fisher will acquire Life Technologies for $76.00 in cash per fully diluted common share or approximately $13.6 billion.
Monday, April 15, 2013
Thermo Fisher Scientific Facilities Achieve ISO 13485 Certification
The facilities in San Jose, CA and Franklin, MA have achieved the internationally recognized standard of quality management for the design and manufacture of medical devices.
Thursday, April 04, 2013
Thermo Fisher Scientific to Acquire picoSpin
Thermo Fisher Scientific Inc. has completed a purchase of picoSpin, LLC, creators of the world’s first miniature NMR spectrometer.
Friday, December 21, 2012
Hyperion Succesfully Completes Laboratory Infrastructure Project for Hellenic Petroleum
Hyperion and the Hellenic Petroleum Group have completed a major upgrade and extension project for the LIMS at three Greek petroleum refineries of the Group.
Wednesday, November 21, 2012
Thermo Fisher Scientific Reports Q3 Revenue and EPS Results
Revenue increased 5% to a record $3.09 billion for the third quarter with adjusted operating income rising 5% to $576 million.
Wednesday, October 24, 2012
Thermo Fisher Scientific and Immundiagnostik Collaborate
The collaboration aims to develop novel mass spectrometry-based assays for qualitative and quantitative analysis of proteins and peptides.
Wednesday, October 17, 2012
Thermo Fisher Scientific and bioMérieux Renew Partnership
The companies have renewed their non-exclusive, long-term, royalty-bearing agreement for Procalcitonin testing.
Wednesday, October 03, 2012
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,300+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!