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A New Matrix Application Device for MALDI Tissue Imaging
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Bruker Daltonics

Abstract
ImagePrep™ provides highly reproducible matrix preparations for MALDI tissue imaging in a fully automated process. On tissue, high quality spectra are obtained from these preparations at a lateral resolution of 50 µm. The quality of MALDI tissue imaging analyses is dependent on the matrix application protocol.

Current protocols have several disadvantages, including lack of reproducibility and analyte delocalization from pneumatic spray, and limited spatial resolution from time consuming nano spotting. Both techniques require experience or time consuming aintenance efforts. The ImagePrep technique is a new approach that consistently provides high resolution images at high speed with superb spectra quality without user intervention.

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