Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>Resources>Application Notes>This Application Note
  Application Notes
Scientific News
The Rise of 3D Cell Culture and in vitro Model Systems for Drug Discovery and Toxicology
An overview of the current technology and the challenges and benefits over 2D cell culture models plus some of the latest advances relating to human health research.
World’s Largest Coral Gene Database
‘Genetic toolkit’ will help shed light on which species survive climate change.
A Boost for Regenerative Medicine
Growing tissues and organs in the lab for transplantation into patients could become easier after scientists discovered an effective way to produce three-dimensional networks of blood vessels, vital for tissue survival yet a current stumbling block in regenerative medicine.
Breast Cancer Drug Hope
A drug for breast cancer that is more effective than existing medicines may be a step closer thanks to new research.
Untangling Disease-Related Protein Misfolding
Work advances understanding of genetic forms of thrombosis, emphysema, cirrhosis of the liver, neurodegenerative diseases and inflammation, among others.
Early Genetic Changes in Premalignant Colorectal Tissue Identified
Findings point to drivers of early cancer development, targets for cancer prevention therapies.
Harnessing Nature’s Vast Array of Venoms for Drug Discovery
Scripps scientists have developed a method for rapidly identifying venoms.
Nanoparticles Target, Transform Fat Tissue
Nanoparticles designed to target white fat and convert it to calorie-burning brown fat slowed weight gain in obese mice without affecting food intake. This proof-of-concept work could lead to new therapies to treat obesity.
New Cancer Fighters Emerge From Lab
Rice University lab simplifies total synthesis of anti-cancer agent.
Scientists Find Evidence That Cancer Can Arise Changes
Researchers at Rockefeller University have found a mutation that affects the proteins that package DNA without changing the DNA itself can cause a rare form of cancer.
Scroll Up
Scroll Down

A global abstract analysis of selected histone-modifying enzymes using AKS
Bookmark and Share


Active Motif

With over 8.4 million PubMed abstracts and with 1000s of new abstracts added daily, it is physically impossible for any conscientious researcher to keep current with all of the newly published research. Most scientists rely on simple information-retrieval techniques to obtain scientific articles pertaining to a topic of interest. However, new sophisticated software programs have been developed to try to understand how biological concepts in scientific literature are used and how these concepts correspond to the query term provided by the user. When searching PubMed abstracts, most life science researchers do not want to be experts in text mining techniques, but simply want to have an all-encompassing understanding of the published information about a biomolecule and its relationship to disease or other biological entities. Therefore, global abstract analysis (GAA) is a novel approach for examining the complexity of information described in PubMed abstracts.

GAA was employed to illustrate how this technique can help uncover additional biological relationships, scientific information, and overall publication trends of a particular collection of biomolecules. In this study we selected twelve histone-modifying enzymes (1). They are important because several common post-translational modifications are driven by these types of histone-modifying enzymes. These resulting modifications influence the structure of chromatin and the dynamic interaction of transcriptional machinery. The modifications include: methylation, demethylation, acetylation, deacetylation, ubiquitination, sumoylation and phosphorylation. Methylation and acetylation are the typical control points between switching from gene silencing to active transcription, whereas hyperacetylated histone tails are associated with active transcription. In addition, ubiquitination is implicated in transcriptional regulation by polycomb silencing and regulation of chromatin structure, while phosphorylated residues on histone tails can be markers for chromatin condensation in mitosis, DNA repair, or apoptosis.

Distinct from traditional simple text search methods, the technique of GAA gives an extensive overview and historical synopsis of the published knowledge of these fascinating histone-modifying enzymes. In this report we describe the application of GAA to a group of disease-associated enzymes and demonstrate how a complete GAA can be developed for any targeted collection of biomolecules for pathway construction, biomarker discovery, or early investigative studies.

Further Information


Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!