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Releasing Cancer Cells for Better Analysis
A new device developed at the University of Michigan could provide a non-invasive way to monitor the progress of an advanced cancer treatment.
Releasing Cancer Cells for Better Analysis
A new device developed at the University of Michigan could provide a non-invasive way to monitor the progress of an advanced cancer treatment.
Apricot Kernels Pose Risk of Cyanide Poisoning
Eating more than three small raw apricot kernels, or less than half of one large kernel, in a serving can exceed safe levels. Toddlers consuming even one small apricot kernel risk being over the safe level.
Cell Transplant Treats Parkinson’s in Mice
A University of Wisconsin—Madison neuroscientist has inserted a genetic switch into nerve cells so a patient can alter their activity by taking designer drugs that would not affect any other cell.
Understanding Female HIV Transmission
Glowing virus maps points of entry through entire female reproductive tract for first time.
Genetic Markers Influence Addiction
Differences in vulnerability to cocaine addiction and relapse linked to both inherited traits and epigenetics, U-M researchers find.
Lab-on-a-Chip for Detecting Glucose
By integrating microfluidic chips with fiber optic biosensors, researchers in China are creating ultrasensitive lab-on-a-chip devices to detect glucose levels.
A lncRNA Regulates Repair of DNA Breaks in Breast Cancer Cells
Findings give "new insight" into biology of tough-to-treat breast cancer.
COPD Linked to Increased Bacterial Invasion
Persistent inflammation in COPD may result from a defect in the immune system that allows airway bacteria to invade deeper into the lung.
Detection of HPV in First-Void Urine
Similar sensitivity of HPV test on first void urine sample compared to cervical smear.
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Novel ProteoPrep® 20 Immunoaffinity Depletion Resin for Human Plasma
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Sigma Aldrich

The study of the human plasma proteome is an area of hugeimportance, especially for the pharmaceutical potential ofidentifying disease biomarkers. Many proteins of interestappear at low concentrations in the plasma and are, therefore,difficult to detect.

Identification of potential biomarkers is especially difficult dueto the presence of higher abundance proteins. To addressthese issues, an affinity resin has been developed for removalof 20 high abundance proteins from 8 µl of plasma. Depletionof these abundant proteins allows for visualization of proteinsthat co-migrate with, and are masked by, the high abundanceproteins during 1-D or 2-D gel electrophoresis andHPLC separations. Plasma proteins can then be loaded ontogels, IPG strips, or HPLC columns at higher levels for improvedvisualization/detection of low copy number proteins.

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