Satellite Banner
Scientific Communities
Become a Member | Sign in
Home>Resources>White Papers>This White Paper
  White Papers
Scientific News
Integrated Omics Analysis
Studying multi-omics promises to give a more holistic picture of the organism and its place in its ecosystem, however despite the complexities involved those within the field are optimistic.
Unravelling the Role of Key Genes and DNA Methylation in Blood Cell Malignancies
Researchers from the University of Nebraska Medical Center have demonstrated the role of Dnmt3a in safeguarding normal haematopoiesis.
Salford Lung Study - The First Real World Clinical Trial
In this podcast, we learn about the Salford Lung Study and its potential to revolutionize the way we assess new drugs and treatments around the world.
Point of Care Diagnostics - A Cautious Revolution
Advances in molecular biology, coupled with the miniaturization and improved sensitivity of assays and devices in general, have enabled a new wave of point-of-care (POC) or “bedside” diagnostics.
Structure of Primary Cannabinoid Receptor is Revealed
The findings provide key insights into how natural and synthetic cannabinoids including tetrahydrocannabinol —a primary chemical in marijuana—bind at the CB1 receptor to produce their effects.
Overlooked Molecules Could Revolutionise our Understanding of the Immune System
Researchers have discovered that around one third of all the epitopes displayed for scanning by the immune system are a type known as ‘spliced’ epitopes.
Illumina Contributes to ClinVar Database
The contribution includes variants of all classifications, from pathogenic to benign, identified during interpretation of whole genome sequences generated in the CLIA-certified, CAP-accredited Illumina Clinical Services Laboratory.
Agilent Presents Early Career Professor Award to Dr. Roeland Verhaak
JAX professor recognized for the development and implementation of workflows for the analysis of big-data from transcriptomics to next generation sequencing approaches.
NIH Study Determines Key Differences between Allergic and Non-Allergic Dust Mite Proteins
Researchers at NIH have uncovered factors that lead to the development of dust mite allergy and assist in the design of better allergy therapies.
NIH Contributes to Global Effort to Prevent and Manage Lung Diseases
The large scale trial will measure health benefits of clean cookstoves.
Scroll Up
Scroll Down

Use of a Label-Free Platform in a preclinical Contract Research Organization Environment
Bookmark and Share

Caliper Life Sciences

Caliper Discovery Alliances & Services (CDAS) is a Contract Research Organization offering comprehensive in vitro and in vivo preclinical contract research services. Their offering is articulated around different platforms including Target Validation with the creation of transgenic animals, Assay Development, Screening, Safety Pharmacology, Biochemical and Functional cell based profiling, Drug Efficacy in disease models and non-invasive small animal Optical Imaging.

NovaScreen Biosciences, now part of CDAS, pioneered receptor profiling studies in the early 1990’s and has established a best in class safety pharmacology platform with a large number of GPCR binding assays. Functional studies are very complementary to affinity-based radioligand assays as they provide very valuable information on the way a drug interacts with a GPCR target.

Using CDAS GPCRFunctional™ programs, you can determine if a drug is an activator or an inhibitor or what its potency and efficacy are for a given GPCR target. Understanding drug functionality is also an important benefit of functional studies and you can for example identify allosteric modulators that are generally difficult to identify using orthosteric ligand-based radioligand binding assays.

Further Information

Related Content

Caliper Life Sciences and IntegenX Enter License Agreement for Microfluidics Patent Portfolio
IntegenX and Caliper Life Sciences announced a license agreement providing IntegenX access to Caliper's microfluidics patent portfolio.
Friday, March 11, 2011
Caliper and Seegene Partner to Provide Innovative Multiplex Molecular Diagnostics Products
Caliper and Seegene partner to deliver innovative diagnostic panels on Caliper's LabChip® Dx platform.
Tuesday, January 18, 2011
Caliper Life Sciences Completes Previously Announced CRi Acquisition
Caliper Life Sciences, Inc. (Nasdaq: CALP), a leading provider of products and services for drug discovery research, announces that it has completed the acquisition of privately-held Cambridge Research & Instrumentation, Inc. (CRi) pursuant to the terms of the merger agreement previously announced on December 9, 2010.
Wednesday, December 22, 2010
Caliper Life Sciences to Acquire Cambridge Research & Instrumentation
Adds Proprietary Multiplexed In Vivo and Tissue Imaging Technology to Caliper's Leading Portfolio of Drug Discovery, Imaging and Diagnostics Solutions.
Friday, December 10, 2010
Peter MacCallum Cancer Centre Expands Cancer Research Efforts with Automation Tool from Caliper Life Sciences
Foundation purchases Caliper’s Staccato system to enable high throughput research processes.
Friday, May 29, 2009
Caliper LS Receives $1.1 Million Task Order from the EPA's ToxCast™ Screening Program
This task order was issued pursuant to a contract that Caliper was awarded by the EPA in April 2007 under the ToxCast program.
Wednesday, August 20, 2008
Caliper Life Sciences Forms Alliance with Horizon Discovery
CDAS expands offering to include screening for targeted cancer drugs using genetically-defined in-vitro human disease models.
Thursday, April 10, 2008
Caliper LS Awarded National Institute of Environmental Health Services Contract Valued to $7 Million
Caliper Discovery Alliances & Services to develop customized transgenic and knock-out mouse models.
Thursday, October 04, 2007
Caliper Life Sciences Introduces High Throughput RNA Assay for Gene Expression Studies
According to Company, the new assay assures integrity of RNA samples and offers improved throughput and walk-away time.
Thursday, September 13, 2007
Caliper Life Sciences Licenses Monogram Biosciences' Microfluidics Patents
Additional intellectual property portfolio to expand and strengthen Caliper Driven™ licensing program.
Thursday, May 03, 2007
Caliper Life Sciences Awarded EPA Contract
Caliper Discovery Alliances and Services unit will test environmental chemicals under EPA’s ToxCast research program.
Tuesday, April 10, 2007
Caliper Life Sciences Launches Drug Discovery and Development Services Business
Caliper combines in vitro and in vivo services of Novascreen Biosciences and Xenogen Biosciences to form Discovery Alliances & Services.
Tuesday, January 09, 2007
Caliper Life Sciences Closes Multiple LabChip and IVIS Sales at Top Pharma and Biotech Companies
Pfizer, AstraZeneca and Momenta Pharmaceuticals purchase Caliper systems for In Vitro and In Vivo research efforts.
Wednesday, December 13, 2006
Caliper Continues Momentum with Expanded LabChip 3000 Sales
Currently 12 of the top 15 pharmaceutical companies actively use Caliper systems as key tools in their discovery efforts.
Friday, May 26, 2006
Caliper Life Sciences Aids the Sanger Institute's Protein Expression Project
The Wellcome Trust Sanger Institute has purchased the microfluidic-based LabChip® 90 Automated Electrophoresis System to quality control DNA and proteins.
Wednesday, April 05, 2006
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,100+ scientific videos