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The Rise of 3D Cell Culture and in vitro Model Systems for Drug Discovery and Toxicology
An overview of the current technology and the challenges and benefits over 2D cell culture models plus some of the latest advances relating to human health research.
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Immune Cells Remember Their First Meal
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A New Platform for Discovering Antibiotics
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Gene That Lowers Heart Attack Risk Identified
Individuals with a rare twelve-letter deletion from a gene on chromosome 17 have significantly reduced non-HDL cholesterol levels and a 35% lower than average risk of heart disease.
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DNA Repair Deficient Cell Lines—Tools to Study Genomic Instability
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Trevigen

DNA Repair Pathways

There are over 150 human proteins that have been categorized as bona fide DNA Repair proteins. These fall into 14 general categories, including the classical DNA Repair pathways of Base Excision Repair (BER), Direct Reversal of Damage, Mismatch Excision Repair (MMR), Nucleotide Excision Repair (NER), Homologous Recombination (HR), Non-Homologous End-Joining (NHEJ) and the Fanconi Anemia/DNA crosslink repair pathway. There are proteins that modulate nucleotide pools, DNA polymerases, and editing and processing nucleases, the Rad6 pathway; proteins that modulate chromatin structure, DNA Repair genes/proteins defective in diseases & conserved DNA Damage Response. Advances in the DNA Repair field inevitably lead to additions to each category as new proteins are found that contribute to the repair of DNA damage or to the cellular response to DNA damage, such as MRG15 involvement in HR via its interaction with PALB2 or DNA2, recently identified as a structure-specific nuclease involved in nuclear and mitochondrial genome maintenance.

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